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The effect of increased alcohol availability on alcohol-related health problems up to the age of 42 among children exposed in utero : A natural experiment

Thern, Emelie; Carslake, David; Smith, George Davey; Tynelius, Per and Rasmussen, Finn LU (2018) In Alcohol and Alcoholism 53(1). p.104-111
Abstract

Aim: To examine whether exposure to increased alcohol availability in utero is associated with later alcohol-related health problems. Method: Register-linked population-based longitudinal study using data from a natural experiment setting, including 363 286 children born 1965-71. An experimental alcohol policy change was piloted in two regions of Sweden in 1967-68, where access to strong beer increased for 16-20 year old. Children exposed in utero to the policy change were compared to children born elsewhere in Sweden (excluding a border area), and to children born before and after the policy change. The outcome was obtained from the National Hospital Discharge Register using the Swedish index of alcohol-related inpatient care. Hazard... (More)

Aim: To examine whether exposure to increased alcohol availability in utero is associated with later alcohol-related health problems. Method: Register-linked population-based longitudinal study using data from a natural experiment setting, including 363 286 children born 1965-71. An experimental alcohol policy change was piloted in two regions of Sweden in 1967-68, where access to strong beer increased for 16-20 year old. Children exposed in utero to the policy change were compared to children born elsewhere in Sweden (excluding a border area), and to children born before and after the policy change. The outcome was obtained from the National Hospital Discharge Register using the Swedish index of alcohol-related inpatient care. Hazard ratios (HR) with 95% confidence intervals (CI) were estimated by Cox regression analysis. Results: The results suggest that children conceived by young mothers prior to the policy change but exposed to it in utero had a slightly increased risk of alcohol-related health problems later in life (HR 1.26, 95% CI 0.94-1.68). A tendency towards an inverse association was found among children conceived by older mothers (HR 0.88, 95% CI 0.74-1.06). Conclusion: Results obtained from a natural experiment setting found no consistent evidence of long-term health consequences among children exposed in utero to an alcohol policy change. Some evidence however suggested an increased risk of alcohol-related health problems among the exposed children of young mothers.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
increased alcohol, children exposed, Health problems
in
Alcohol and Alcoholism
volume
53
issue
1
pages
8 pages
publisher
Oxford University Press
external identifiers
  • scopus:85040522864
  • pmid:29053772
ISSN
0735-0414
DOI
10.1093/alcalc/agx069
language
English
LU publication?
yes
id
b10ff168-695b-455c-8e55-ce713e5bc439
date added to LUP
2018-02-05 12:41:19
date last changed
2018-06-05 14:50:43
@article{b10ff168-695b-455c-8e55-ce713e5bc439,
  abstract     = {<p>Aim: To examine whether exposure to increased alcohol availability in utero is associated with later alcohol-related health problems. Method: Register-linked population-based longitudinal study using data from a natural experiment setting, including 363 286 children born 1965-71. An experimental alcohol policy change was piloted in two regions of Sweden in 1967-68, where access to strong beer increased for 16-20 year old. Children exposed in utero to the policy change were compared to children born elsewhere in Sweden (excluding a border area), and to children born before and after the policy change. The outcome was obtained from the National Hospital Discharge Register using the Swedish index of alcohol-related inpatient care. Hazard ratios (HR) with 95% confidence intervals (CI) were estimated by Cox regression analysis. Results: The results suggest that children conceived by young mothers prior to the policy change but exposed to it in utero had a slightly increased risk of alcohol-related health problems later in life (HR 1.26, 95% CI 0.94-1.68). A tendency towards an inverse association was found among children conceived by older mothers (HR 0.88, 95% CI 0.74-1.06). Conclusion: Results obtained from a natural experiment setting found no consistent evidence of long-term health consequences among children exposed in utero to an alcohol policy change. Some evidence however suggested an increased risk of alcohol-related health problems among the exposed children of young mothers.</p>},
  author       = {Thern, Emelie and Carslake, David and Smith, George Davey and Tynelius, Per and Rasmussen, Finn},
  issn         = {0735-0414},
  keyword      = {increased alcohol,children exposed,Health problems},
  language     = {eng},
  month        = {01},
  number       = {1},
  pages        = {104--111},
  publisher    = {Oxford University Press},
  series       = {Alcohol and Alcoholism},
  title        = {The effect of increased alcohol availability on alcohol-related health problems up to the age of 42 among children exposed in utero : A natural experiment},
  url          = {http://dx.doi.org/10.1093/alcalc/agx069},
  volume       = {53},
  year         = {2018},
}