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The inverse association between a fish consumption biomarker and gingival inflammation and periodontitis : A population-based study

Ottosson, Filip LU ; Hultgren, Lina ; Fernandez, Celine LU ; Engström, Gunnar LU ; Orho-Melander, Marju LU ; Kennbäck, Cecilia LU ; Persson, Margaretha LU orcid ; Demmer, Ryan T. ; Melander, Olle LU orcid and Klinge, Björn , et al. (2022) In Journal of Clinical Periodontology 49(4). p.353-361
Abstract

Aim: The metabolite 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid (CMPF) is a fatty fish–intake biomarker. We investigated the association between plasma levels of CMPF in relation to gingival inflammation and periodontitis case definition, as well as the extent and severity variables. Materials and Methods: The Malmö Offspring Study is a population-based study, and the Malmö Offspring Dental Study (MODS) is its dental arm, including periodontal charting. Plasma CMPF was measured using liquid chromatography–mass spectrometry and studied in relation to periodontal diagnosis and parameters using multivariable linear or logistic regression modelling adjusting for age, sex, education, body mass index, fasting glucose, and smoking.... (More)

Aim: The metabolite 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid (CMPF) is a fatty fish–intake biomarker. We investigated the association between plasma levels of CMPF in relation to gingival inflammation and periodontitis case definition, as well as the extent and severity variables. Materials and Methods: The Malmö Offspring Study is a population-based study, and the Malmö Offspring Dental Study (MODS) is its dental arm, including periodontal charting. Plasma CMPF was measured using liquid chromatography–mass spectrometry and studied in relation to periodontal diagnosis and parameters using multivariable linear or logistic regression modelling adjusting for age, sex, education, body mass index, fasting glucose, and smoking. Results: Metabolite data were available for 922 MODS participants. Higher CMPF levels were associated with less gingival inflammation (β = −2.12, p =.002) and lower odds of severe periodontitis (odds ratio [OR] = 0.74, 95% confidence interval [CI]: 0.56 to 0.98). Higher CMPF levels were also associated with more teeth (β = 0.19, p =.001), lower number of periodontal pockets (≥4 mm) (β = −1.07, p =.007), and lower odds of having two or more periodontal pockets of ≥6 mm (OR = 0.80, 95% CI: 0.65 to 0.98) in fully adjusted models. Conclusions: CMPF, a validated biomarker of fatty fish consumption, is associated with less periodontal inflammation and periodontitis. Residual confounding cannot be ruled out, and future studies are warranted.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
CMPF, fish diet, gingival inflammation, metabolomics, periodontitis
in
Journal of Clinical Periodontology
volume
49
issue
4
pages
9 pages
publisher
Wiley-Blackwell
external identifiers
  • pmid:35132662
  • scopus:85125390945
ISSN
0303-6979
DOI
10.1111/jcpe.13602
language
English
LU publication?
yes
id
b1231024-2480-4740-b833-39f834a881ef
date added to LUP
2022-04-19 14:25:18
date last changed
2024-04-20 13:51:00
@article{b1231024-2480-4740-b833-39f834a881ef,
  abstract     = {{<p>Aim: The metabolite 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid (CMPF) is a fatty fish–intake biomarker. We investigated the association between plasma levels of CMPF in relation to gingival inflammation and periodontitis case definition, as well as the extent and severity variables. Materials and Methods: The Malmö Offspring Study is a population-based study, and the Malmö Offspring Dental Study (MODS) is its dental arm, including periodontal charting. Plasma CMPF was measured using liquid chromatography–mass spectrometry and studied in relation to periodontal diagnosis and parameters using multivariable linear or logistic regression modelling adjusting for age, sex, education, body mass index, fasting glucose, and smoking. Results: Metabolite data were available for 922 MODS participants. Higher CMPF levels were associated with less gingival inflammation (β = −2.12, p =.002) and lower odds of severe periodontitis (odds ratio [OR] = 0.74, 95% confidence interval [CI]: 0.56 to 0.98). Higher CMPF levels were also associated with more teeth (β = 0.19, p =.001), lower number of periodontal pockets (≥4 mm) (β = −1.07, p =.007), and lower odds of having two or more periodontal pockets of ≥6 mm (OR = 0.80, 95% CI: 0.65 to 0.98) in fully adjusted models. Conclusions: CMPF, a validated biomarker of fatty fish consumption, is associated with less periodontal inflammation and periodontitis. Residual confounding cannot be ruled out, and future studies are warranted.</p>}},
  author       = {{Ottosson, Filip and Hultgren, Lina and Fernandez, Celine and Engström, Gunnar and Orho-Melander, Marju and Kennbäck, Cecilia and Persson, Margaretha and Demmer, Ryan T. and Melander, Olle and Klinge, Björn and Nilsson, Peter M. and Jönsson, Daniel}},
  issn         = {{0303-6979}},
  keywords     = {{CMPF; fish diet; gingival inflammation; metabolomics; periodontitis}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{353--361}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Journal of Clinical Periodontology}},
  title        = {{The inverse association between a fish consumption biomarker and gingival inflammation and periodontitis : A population-based study}},
  url          = {{http://dx.doi.org/10.1111/jcpe.13602}},
  doi          = {{10.1111/jcpe.13602}},
  volume       = {{49}},
  year         = {{2022}},
}