Impact of cardiac dysfunction on health-related quality of life in cirrhotic liver transplant candidates
(2015) In European Journal of Gastroenterology and Hepathology 27(4). p.393-398- Abstract
- Objective Cardiac dysfunction, in particular left ventricular diastolic dysfunction, is common in cirrhosis. We aimed to investigate the impact of cardiac dysfunction on health-related quality of life (QoL) in liver cirrhosis. Materials and methods A total of 88 cirrhotic liver transplant candidates with an available echocardiogram and ECG completed the Short form-36 (SF-36) and Fatigue Impact Scale. In a subgroup of 61 patients, levels of cardiac biomarkers, in particular serum N-terminal pro-brain natriuretic peptide, adiponectin, and high-sensitive troponin T, were also measured. Results Although left ventricular systolic diameter was related to a lower SF-36 physical component summary, neither left ventricular diastolic dysfunction nor... (More)
- Objective Cardiac dysfunction, in particular left ventricular diastolic dysfunction, is common in cirrhosis. We aimed to investigate the impact of cardiac dysfunction on health-related quality of life (QoL) in liver cirrhosis. Materials and methods A total of 88 cirrhotic liver transplant candidates with an available echocardiogram and ECG completed the Short form-36 (SF-36) and Fatigue Impact Scale. In a subgroup of 61 patients, levels of cardiac biomarkers, in particular serum N-terminal pro-brain natriuretic peptide, adiponectin, and high-sensitive troponin T, were also measured. Results Although left ventricular systolic diameter was related to a lower SF-36 physical component summary, neither left ventricular diastolic dysfunction nor any other echocardiographic feature was found to be associated with any other SF-36 or Fatigue Impact Scale domain (P>0.05 for all). On linear regression analysis after adjustment for confounders, a prolonged QTc interval was found to be related to a lower SF-36 mental component summary score (beta = -9.7, P = 0.009) and increased physical fatigue (beta = 10.5, P= 0.004). Neither serum N-terminal pro-brain natriuretic peptide, high-sensitivity troponin T, nor adiponectin levels were found to be related to QoL (P> 0.05 for all). Serum adiponectin levels did not differ among patients with versus those without echocardiographic cardiac alterations (P> 0.05 for all). Conclusion A prolonged QTc interval, but not any echocardiographic abnormalities or cardiac biomarkers, seems to be predictive of QoL in cirrhosis. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved. (Less)
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https://lup.lub.lu.se/record/5294017
- author
- Josefsson, Axel ; Fu, Michael ; Björnsson, Einar ; Castedal, Maria and Kalaitzakis, Evangelos LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cirrhotic cardiomyopathy, fatigue, health-related quality of life, left, ventricular diastolic dysfunction, liver cirrhosis, liver, transplantation
- in
- European Journal of Gastroenterology and Hepathology
- volume
- 27
- issue
- 4
- pages
- 393 - 398
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- wos:000350763800006
- scopus:84924902162
- pmid:25874511
- pmid:25874511
- ISSN
- 1473-5687
- DOI
- 10.1097/MEG.0000000000000292
- language
- English
- LU publication?
- yes
- id
- b12e875c-f0ae-4d6e-917b-106b40f7cfd3 (old id 5294017)
- date added to LUP
- 2016-04-01 10:12:15
- date last changed
- 2024-01-06 10:27:36
@article{b12e875c-f0ae-4d6e-917b-106b40f7cfd3,
abstract = {{Objective Cardiac dysfunction, in particular left ventricular diastolic dysfunction, is common in cirrhosis. We aimed to investigate the impact of cardiac dysfunction on health-related quality of life (QoL) in liver cirrhosis. Materials and methods A total of 88 cirrhotic liver transplant candidates with an available echocardiogram and ECG completed the Short form-36 (SF-36) and Fatigue Impact Scale. In a subgroup of 61 patients, levels of cardiac biomarkers, in particular serum N-terminal pro-brain natriuretic peptide, adiponectin, and high-sensitive troponin T, were also measured. Results Although left ventricular systolic diameter was related to a lower SF-36 physical component summary, neither left ventricular diastolic dysfunction nor any other echocardiographic feature was found to be associated with any other SF-36 or Fatigue Impact Scale domain (P>0.05 for all). On linear regression analysis after adjustment for confounders, a prolonged QTc interval was found to be related to a lower SF-36 mental component summary score (beta = -9.7, P = 0.009) and increased physical fatigue (beta = 10.5, P= 0.004). Neither serum N-terminal pro-brain natriuretic peptide, high-sensitivity troponin T, nor adiponectin levels were found to be related to QoL (P> 0.05 for all). Serum adiponectin levels did not differ among patients with versus those without echocardiographic cardiac alterations (P> 0.05 for all). Conclusion A prolonged QTc interval, but not any echocardiographic abnormalities or cardiac biomarkers, seems to be predictive of QoL in cirrhosis. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved.}},
author = {{Josefsson, Axel and Fu, Michael and Björnsson, Einar and Castedal, Maria and Kalaitzakis, Evangelos}},
issn = {{1473-5687}},
keywords = {{cirrhotic cardiomyopathy; fatigue; health-related quality of life; left; ventricular diastolic dysfunction; liver cirrhosis; liver; transplantation}},
language = {{eng}},
number = {{4}},
pages = {{393--398}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{European Journal of Gastroenterology and Hepathology}},
title = {{Impact of cardiac dysfunction on health-related quality of life in cirrhotic liver transplant candidates}},
url = {{http://dx.doi.org/10.1097/MEG.0000000000000292}},
doi = {{10.1097/MEG.0000000000000292}},
volume = {{27}},
year = {{2015}},
}