Development and Optimization of a Single Column Analog Model for a Multi-Column Counter-Current Solvent Gradient Purification Process
(2017) In Computer Aided Chemical Engineering 40. p.187-192- Abstract
- This contribution presents a modeling and optimization method for multi-column counter-current purification (MCSGP) processes. The model is based on conventional column models and by using the symmetric and cyclic steady state characteristics of the process a single column analog model was developed. The model have been used for dynamic optimization of the MCSGP process. The optimization was based on a simultaneous method where the control and state variables were discretized using a direct and local collocation method on finite elements in the temporal dimension and a finite volume weighted essentially non-oscillatory (WENO) scheme in the spatial dimension. The resulting nonlinear program (NLP) were solved using an interior point... (More)
- This contribution presents a modeling and optimization method for multi-column counter-current purification (MCSGP) processes. The model is based on conventional column models and by using the symmetric and cyclic steady state characteristics of the process a single column analog model was developed. The model have been used for dynamic optimization of the MCSGP process. The optimization was based on a simultaneous method where the control and state variables were discretized using a direct and local collocation method on finite elements in the temporal dimension and a finite volume weighted essentially non-oscillatory (WENO) scheme in the spatial dimension. The resulting nonlinear program (NLP) were solved using an interior point method.
The case study presented shows that the zero-order hold elution trajectories, developed for single column batch operation, can be extended to semi-continuous multi-column chromatography with product recycling. The optimization results is composed of a set of operating conditions where the product was upgraded to 95% purity with 99% process yield. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/b13ef594-e959-4e2b-a18c-7615062648f4
- author
- Sellberg, Anton
LU
; Andersson, Niklas
LU
; Holmqvist, Anders LU and Nilsson, Bernt LU
- organization
- publishing date
- 2017-10-01
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- modellering, optimering, protein, Kromatografi
- host publication
- 27th European Symposium on Computer Aided Process Engineering
- series title
- Computer Aided Chemical Engineering
- editor
- Espuña, Antonio ; Graells, Moisès and Puigjaner, Luis
- volume
- 40
- pages
- 6 pages
- external identifiers
-
- wos:000417380000033
- scopus:85041395626
- ISSN
- 1570-7946
- ISBN
- 9780444639707
- 0444639705
- DOI
- 10.1016/B978-0-444-63965-3.50033-7
- project
- PICLU
- language
- English
- LU publication?
- yes
- id
- b13ef594-e959-4e2b-a18c-7615062648f4
- date added to LUP
- 2017-11-07 16:39:19
- date last changed
- 2025-01-08 00:12:17
@inbook{b13ef594-e959-4e2b-a18c-7615062648f4, abstract = {{This contribution presents a modeling and optimization method for multi-column counter-current purification (MCSGP) processes. The model is based on conventional column models and by using the symmetric and cyclic steady state characteristics of the process a single column analog model was developed. The model have been used for dynamic optimization of the MCSGP process. The optimization was based on a simultaneous method where the control and state variables were discretized using a direct and local collocation method on finite elements in the temporal dimension and a finite volume weighted essentially non-oscillatory (WENO) scheme in the spatial dimension. The resulting nonlinear program (NLP) were solved using an interior point method.<br/><br/>The case study presented shows that the zero-order hold elution trajectories, developed for single column batch operation, can be extended to semi-continuous multi-column chromatography with product recycling. The optimization results is composed of a set of operating conditions where the product was upgraded to 95% purity with 99% process yield.}}, author = {{Sellberg, Anton and Andersson, Niklas and Holmqvist, Anders and Nilsson, Bernt}}, booktitle = {{27th European Symposium on Computer Aided Process Engineering}}, editor = {{Espuña, Antonio and Graells, Moisès and Puigjaner, Luis}}, isbn = {{9780444639707}}, issn = {{1570-7946}}, keywords = {{modellering; optimering; protein; Kromatografi}}, language = {{eng}}, month = {{10}}, pages = {{187--192}}, series = {{Computer Aided Chemical Engineering}}, title = {{Development and Optimization of a Single Column Analog Model for a Multi-Column Counter-Current Solvent Gradient Purification Process}}, url = {{http://dx.doi.org/10.1016/B978-0-444-63965-3.50033-7}}, doi = {{10.1016/B978-0-444-63965-3.50033-7}}, volume = {{40}}, year = {{2017}}, }