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Development and Optimization of a Single Column Analog Model for a Multi-Column Counter-Current Solvent Gradient Purification Process

Sellberg, Anton LU ; Andersson, Niklas LU ; Holmqvist, Anders LU and Nilsson, Bernt LU (2017) In 27th European Symposium on Computer Aided Process Engineering 40. p.187-192
Abstract
This contribution presents a modeling and optimization method for multi-column counter-current purification (MCSGP) processes. The model is based on conventional column models and by using the symmetric and cyclic steady state characteristics of the process a single column analog model was developed. The model have been used for dynamic optimization of the MCSGP process. The optimization was based on a simultaneous method where the control and state variables were discretized using a direct and local collocation method on finite elements in the temporal dimension and a finite volume weighted essentially non-oscillatory (WENO) scheme in the spatial dimension. The resulting nonlinear program (NLP) were solved using an interior point... (More)
This contribution presents a modeling and optimization method for multi-column counter-current purification (MCSGP) processes. The model is based on conventional column models and by using the symmetric and cyclic steady state characteristics of the process a single column analog model was developed. The model have been used for dynamic optimization of the MCSGP process. The optimization was based on a simultaneous method where the control and state variables were discretized using a direct and local collocation method on finite elements in the temporal dimension and a finite volume weighted essentially non-oscillatory (WENO) scheme in the spatial dimension. The resulting nonlinear program (NLP) were solved using an interior point method.

The case study presented shows that the zero-order hold elution trajectories, developed for single column batch operation, can be extended to semi-continuous multi-column chromatography with product recycling. The optimization results is composed of a set of operating conditions where the product was upgraded to 95% purity with 99% process yield. (Less)
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author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
modellering, optimering, protein, Kromatografi
in
27th European Symposium on Computer Aided Process Engineering
editor
Espuña, Antonio; Graells, Moisès; Puigjaner, Luis; ; and
volume
40
pages
6 pages
external identifiers
  • wos:000417380000033
  • scopus:85041395626
ISSN
1570-7946
ISBN
0444639705
9780444639707
DOI
10.1016/B978-0-444-63965-3.50033-7
language
English
LU publication?
yes
id
b13ef594-e959-4e2b-a18c-7615062648f4
date added to LUP
2017-11-07 16:39:19
date last changed
2018-02-18 05:05:13
@inbook{b13ef594-e959-4e2b-a18c-7615062648f4,
  abstract     = {This contribution presents a modeling and optimization method for multi-column counter-current purification (MCSGP) processes. The model is based on conventional column models and by using the symmetric and cyclic steady state characteristics of the process a single column analog model was developed. The model have been used for dynamic optimization of the MCSGP process. The optimization was based on a simultaneous method where the control and state variables were discretized using a direct and local collocation method on finite elements in the temporal dimension and a finite volume weighted essentially non-oscillatory (WENO) scheme in the spatial dimension. The resulting nonlinear program (NLP) were solved using an interior point method.<br/><br/>The case study presented shows that the zero-order hold elution trajectories, developed for single column batch operation, can be extended to semi-continuous multi-column chromatography with product recycling. The optimization results is composed of a set of operating conditions where the product was upgraded to 95% purity with 99% process yield.},
  author       = {Sellberg, Anton and Andersson, Niklas and Holmqvist, Anders and Nilsson, Bernt},
  editor       = {Espuña, Antonio and Graells, Moisès and Puigjaner, Luis},
  isbn         = {0444639705},
  issn         = {1570-7946},
  keyword      = {modellering,optimering,protein,Kromatografi},
  language     = {eng},
  month        = {10},
  pages        = {187--192},
  series       = {27th European Symposium on Computer Aided Process Engineering},
  title        = {Development and Optimization of a Single Column Analog Model for a Multi-Column Counter-Current Solvent Gradient Purification Process},
  url          = {http://dx.doi.org/10.1016/B978-0-444-63965-3.50033-7},
  volume       = {40},
  year         = {2017},
}