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Cancer heterogeneity determined by functional proteomics

Szász, Marcell LU ; Gyorffy, Balázs and Marko-Varga, György LU (2017) In Seminars in Cell and Developmental Biology 64. p.132-142
Abstract

Current manuscript gives a synopsis of tumor heterogeneity related to patient samples analyzed by proteomics, protein expression analysis and imaging mass spectrometry.First, we discuss the pathophysiologocal background of cancer biology as a multifactorial and challenging diseases. Disease pathology forms the basis for protein target selection. Therefore, histopathological diagnostics and grading of tumors is highlighted. Pathology is the cornerstone of state-of-the-art diagnostics of tumors today both by establishing dignity and - when needed - describing molecular properties of the cancers. Drug development by the pharmaceutical industry utilizes proteomics studies to pinpoint the most relevant targets. Molecular studies profiling... (More)

Current manuscript gives a synopsis of tumor heterogeneity related to patient samples analyzed by proteomics, protein expression analysis and imaging mass spectrometry.First, we discuss the pathophysiologocal background of cancer biology as a multifactorial and challenging diseases. Disease pathology forms the basis for protein target selection. Therefore, histopathological diagnostics and grading of tumors is highlighted. Pathology is the cornerstone of state-of-the-art diagnostics of tumors today both by establishing dignity and - when needed - describing molecular properties of the cancers. Drug development by the pharmaceutical industry utilizes proteomics studies to pinpoint the most relevant targets. Molecular studies profiling affinity-interactions of the protein(s) with targeted small drug molecules to reach efficacy and optimal patient safety are today requested by the FDA and other agencies for new drug development.An understading of basic mechanisms, controlling drug action and drug binding is central, as a new era of personalized medicine becomes an important milestone solution for the healthcare sector as well as the Pharma and Biotech industry. Development of further diagnostic, prognostic and predictive tests will aid current and future treatment of cancer patients.In the paper we present current status of Proteomics that we believe requires attention in order to collectively advance forward in the fight against cancer, addressing the burning opportunities and challenges.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Biomarkers, Cancer heterogeneity, Clinical study, Genomics, Multiple reaction monitoring (MRM), Parallel reaction monitoring (PRM), Proteomics, Single reaction monitoring (SRM)
in
Seminars in Cell and Developmental Biology
volume
64
pages
11 pages
publisher
Academic Press
external identifiers
  • scopus:84995366730
ISSN
1084-9521
DOI
10.1016/j.semcdb.2016.08.026
language
English
LU publication?
yes
id
b16c224c-c8f0-4ecf-8b2a-cbf2e3c53662
date added to LUP
2017-01-12 12:47:03
date last changed
2018-01-07 11:44:32
@article{b16c224c-c8f0-4ecf-8b2a-cbf2e3c53662,
  abstract     = {<p>Current manuscript gives a synopsis of tumor heterogeneity related to patient samples analyzed by proteomics, protein expression analysis and imaging mass spectrometry.First, we discuss the pathophysiologocal background of cancer biology as a multifactorial and challenging diseases. Disease pathology forms the basis for protein target selection. Therefore, histopathological diagnostics and grading of tumors is highlighted. Pathology is the cornerstone of state-of-the-art diagnostics of tumors today both by establishing dignity and - when needed - describing molecular properties of the cancers. Drug development by the pharmaceutical industry utilizes proteomics studies to pinpoint the most relevant targets. Molecular studies profiling affinity-interactions of the protein(s) with targeted small drug molecules to reach efficacy and optimal patient safety are today requested by the FDA and other agencies for new drug development.An understading of basic mechanisms, controlling drug action and drug binding is central, as a new era of personalized medicine becomes an important milestone solution for the healthcare sector as well as the Pharma and Biotech industry. Development of further diagnostic, prognostic and predictive tests will aid current and future treatment of cancer patients.In the paper we present current status of Proteomics that we believe requires attention in order to collectively advance forward in the fight against cancer, addressing the burning opportunities and challenges.</p>},
  author       = {Szász, Marcell and Gyorffy, Balázs and Marko-Varga, György},
  issn         = {1084-9521},
  keyword      = {Biomarkers,Cancer heterogeneity,Clinical study,Genomics,Multiple reaction monitoring (MRM),Parallel reaction monitoring (PRM),Proteomics,Single reaction monitoring (SRM)},
  language     = {eng},
  pages        = {132--142},
  publisher    = {Academic Press},
  series       = {Seminars in Cell and Developmental Biology},
  title        = {Cancer heterogeneity determined by functional proteomics},
  url          = {http://dx.doi.org/10.1016/j.semcdb.2016.08.026},
  volume       = {64},
  year         = {2017},
}