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Multimodal soft tissue markers for bridging high-resolution diagnostic imaging with therapeutic intervention

Hansen, Anders E. ; Henriksen, Jonas R. ; Jølck, Rasmus I. ; Fliedner, Frederikke P. ; Bruun, Linda M. ; Scherman, Jonas ; Jensen, Andreas I. ; Munck Af Rosenschöld, Per LU ; Moorman, Lilah and Kurbegovic, Sorel , et al. (2020) In Science Advances 6(34). p.5353-5353
Abstract

Diagnostic imaging often outperforms the surgeon's ability to identify small structures during therapeutic procedures. Smart soft tissue markers that translate the sensitivity of diagnostic imaging into optimal therapeutic intervention are therefore highly warranted. This paper presents a unique adaptable liquid soft tissue marker system based on functionalized carbohydrates (Carbo-gel). The liquid state of these markers allows for high-precision placement under image guidance using thin needles. Based on step-by-step modifications, the image features and mechanical properties of markers can be optimized to bridge diagnostic imaging and specific therapeutic interventions. The performance of Carbo-gel is demonstrated for markers that (i)... (More)

Diagnostic imaging often outperforms the surgeon's ability to identify small structures during therapeutic procedures. Smart soft tissue markers that translate the sensitivity of diagnostic imaging into optimal therapeutic intervention are therefore highly warranted. This paper presents a unique adaptable liquid soft tissue marker system based on functionalized carbohydrates (Carbo-gel). The liquid state of these markers allows for high-precision placement under image guidance using thin needles. Based on step-by-step modifications, the image features and mechanical properties of markers can be optimized to bridge diagnostic imaging and specific therapeutic interventions. The performance of Carbo-gel is demonstrated for markers that (i) have radiographic, magnetic resonance, and ultrasound visibility; (ii) are palpable and visible; and (iii) are localizable by near-infrared fluorescence and radio guidance. The study demonstrates encouraging proof of concept for the liquid marker system as a well-tolerated multimodal imaging marker that can improve image-guided radiotherapy and surgical interventions, including robotic surgery.

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publishing date
type
Contribution to journal
publication status
published
subject
in
Science Advances
volume
6
issue
34
pages
5353 - 5353
publisher
American Association for the Advancement of Science (AAAS)
external identifiers
  • pmid:32875113
  • scopus:85090180117
ISSN
2375-2548
DOI
10.1126/sciadv.abb5353
language
English
LU publication?
no
id
b20c7abe-1bd0-4e5a-8d65-7533530ae75d
date added to LUP
2020-09-23 10:58:22
date last changed
2021-04-06 03:17:49
@article{b20c7abe-1bd0-4e5a-8d65-7533530ae75d,
  abstract     = {<p>Diagnostic imaging often outperforms the surgeon's ability to identify small structures during therapeutic procedures. Smart soft tissue markers that translate the sensitivity of diagnostic imaging into optimal therapeutic intervention are therefore highly warranted. This paper presents a unique adaptable liquid soft tissue marker system based on functionalized carbohydrates (Carbo-gel). The liquid state of these markers allows for high-precision placement under image guidance using thin needles. Based on step-by-step modifications, the image features and mechanical properties of markers can be optimized to bridge diagnostic imaging and specific therapeutic interventions. The performance of Carbo-gel is demonstrated for markers that (i) have radiographic, magnetic resonance, and ultrasound visibility; (ii) are palpable and visible; and (iii) are localizable by near-infrared fluorescence and radio guidance. The study demonstrates encouraging proof of concept for the liquid marker system as a well-tolerated multimodal imaging marker that can improve image-guided radiotherapy and surgical interventions, including robotic surgery.</p>},
  author       = {Hansen, Anders E. and Henriksen, Jonas R. and Jølck, Rasmus I. and Fliedner, Frederikke P. and Bruun, Linda M. and Scherman, Jonas and Jensen, Andreas I. and Munck Af Rosenschöld, Per and Moorman, Lilah and Kurbegovic, Sorel and de Blanck, Steen R. and Larsen, Klaus R. and Clementsen, Paul F. and Christensen, Anders N. and Clausen, Mads H. and Wang, Wenbo and Kempen, Paul and Christensen, Merete and Viby, Niels Erik and Persson, Gitte and Larsen, Rasmus and Conradsen, Knut and McEvoy, Fintan J. and Kjaer, Andreas and Eriksen, Thomas and Andresen, Thomas L.},
  issn         = {2375-2548},
  language     = {eng},
  month        = {08},
  number       = {34},
  pages        = {5353--5353},
  publisher    = {American Association for the Advancement of Science (AAAS)},
  series       = {Science Advances},
  title        = {Multimodal soft tissue markers for bridging high-resolution diagnostic imaging with therapeutic intervention},
  url          = {http://dx.doi.org/10.1126/sciadv.abb5353},
  doi          = {10.1126/sciadv.abb5353},
  volume       = {6},
  year         = {2020},
}