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Osteoarthritis-related walking disability and arterial stiffness-results from a cross-sectional study

Joseph, Kenth L ; Hagen, Kåre B ; Tveter, Anne T ; Magnusson, Karin LU ; Provan, Sella A and Dagfinrud, Hanne (2019) In Arthritis care and research : the official journal of the Arthritis Health Professions Association 71(2). p.252-258
Abstract

OBJECTIVES: To compare 6 minute walking distance (6MWD) in a population-based osteoarthritis (OA) cohort with matched peers from the general population, and to explore the associations between walking ability and CVD risk (arterial stiffness) in the OA cohort.

DESIGN: This cross-sectional study included participants (40-80 years) who self-reported OA (n=500) in a population-based study and age- and gender-matched peers from the general population (n=235). Clinical examinations of the OA participants included classification according to the American College of Rheumatology criteria, blood samples and measuring arterial stiffness (pulse wave velocity, PWV). Group differences in 6MWD were calculated with t-tests. The association... (More)

OBJECTIVES: To compare 6 minute walking distance (6MWD) in a population-based osteoarthritis (OA) cohort with matched peers from the general population, and to explore the associations between walking ability and CVD risk (arterial stiffness) in the OA cohort.

DESIGN: This cross-sectional study included participants (40-80 years) who self-reported OA (n=500) in a population-based study and age- and gender-matched peers from the general population (n=235). Clinical examinations of the OA participants included classification according to the American College of Rheumatology criteria, blood samples and measuring arterial stiffness (pulse wave velocity, PWV). Group differences in 6MWD were calculated with t-tests. The association between walking ability and CVD risk in the OA cohort was explored in multivariate regression models.

RESULTS: In age stratified analyses, the largest mean difference in 6MWD was observed in the youngest age groups (40-49 years); the OA group walked 84.6 meters (female; 579.4 m vs 663.9 m, p<0.001) and 88.3 meters (male; 619.9 m vs 708.3 m, p=0.001) shorter than the reference groups, respectively. In the OA group, the 6MWD was significantly associated to PWV in adjusted analysis (p=0.001); 100 m longer walking distance corresponded to 0.3 m/s reduction in arterial stiffness.

CONCLUSION: Already from the age of forty, people with OA have significantly shorter mean walking distance compared to matched peers, underlining the importance of early clinical approach to OA. Further, in the OA-group, the 6MWD was significantly associated with arterial stiffness, suggesting that walking ability is important for the CVD risk profile in OA. This article is protected by copyright. All rights reserved.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Arthritis care and research : the official journal of the Arthritis Health Professions Association
volume
71
issue
2
pages
252 - 258
publisher
John Wiley & Sons
external identifiers
  • pmid:29975013
  • scopus:85060756600
ISSN
0893-7524
DOI
10.1002/acr.23697
language
English
LU publication?
yes
id
b21d3f59-27ca-415d-8b73-32be84e582d6
date added to LUP
2018-11-29 15:05:52
date last changed
2019-03-05 04:29:30
@article{b21d3f59-27ca-415d-8b73-32be84e582d6,
  abstract     = {<p>OBJECTIVES: To compare 6 minute walking distance (6MWD) in a population-based osteoarthritis (OA) cohort with matched peers from the general population, and to explore the associations between walking ability and CVD risk (arterial stiffness) in the OA cohort.</p><p>DESIGN: This cross-sectional study included participants (40-80 years) who self-reported OA (n=500) in a population-based study and age- and gender-matched peers from the general population (n=235). Clinical examinations of the OA participants included classification according to the American College of Rheumatology criteria, blood samples and measuring arterial stiffness (pulse wave velocity, PWV). Group differences in 6MWD were calculated with t-tests. The association between walking ability and CVD risk in the OA cohort was explored in multivariate regression models.</p><p>RESULTS: In age stratified analyses, the largest mean difference in 6MWD was observed in the youngest age groups (40-49 years); the OA group walked 84.6 meters (female; 579.4 m vs 663.9 m, p&lt;0.001) and 88.3 meters (male; 619.9 m vs 708.3 m, p=0.001) shorter than the reference groups, respectively. In the OA group, the 6MWD was significantly associated to PWV in adjusted analysis (p=0.001); 100 m longer walking distance corresponded to 0.3 m/s reduction in arterial stiffness.</p><p>CONCLUSION: Already from the age of forty, people with OA have significantly shorter mean walking distance compared to matched peers, underlining the importance of early clinical approach to OA. Further, in the OA-group, the 6MWD was significantly associated with arterial stiffness, suggesting that walking ability is important for the CVD risk profile in OA. This article is protected by copyright. All rights reserved.</p>},
  author       = {Joseph, Kenth L and Hagen, Kåre B and Tveter, Anne T and Magnusson, Karin and Provan, Sella A and Dagfinrud, Hanne},
  issn         = {0893-7524},
  language     = {eng},
  number       = {2},
  pages        = {252--258},
  publisher    = {John Wiley & Sons},
  series       = {Arthritis care and research : the official journal of the Arthritis Health Professions Association},
  title        = {Osteoarthritis-related walking disability and arterial stiffness-results from a cross-sectional study},
  url          = {http://dx.doi.org/10.1002/acr.23697},
  doi          = {10.1002/acr.23697},
  volume       = {71},
  year         = {2019},
}