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Pulmonary Embolism : Ventilation/Perfusion Scintigraphy as a Proper Tool in Diagnosing Pulmonary Embolism and Frequent Pulmonary Comorbidities

Bajc, Marika LU and Lindqvist, Ari (2022) 2. p.92-102
Abstract

Ventilation/perfusion single photon emission computed tomography (V/P SPECT) is the recommended method for proper diagnosis of pulmonary embolism (PE), according to the European Association of Nuclear Medicine (EANM) guidelines. Adequate V/P SPECT acquisition starts with ventilation and continues immediately with perfusion. The whole procedure takes 20min by using an optimal combination of nuclide activities, collimators, and imaging matrix. For the ventilation studies, Technegas particles have an advantage over radiolabeled liquid aerosols due to the better penetration to the periphery. Radiolabeled macro aggregated human albumin (MAA) is the imaging agent of choice for perfusion scintigraphy. The method allows recognition of V/P... (More)

Ventilation/perfusion single photon emission computed tomography (V/P SPECT) is the recommended method for proper diagnosis of pulmonary embolism (PE), according to the European Association of Nuclear Medicine (EANM) guidelines. Adequate V/P SPECT acquisition starts with ventilation and continues immediately with perfusion. The whole procedure takes 20min by using an optimal combination of nuclide activities, collimators, and imaging matrix. For the ventilation studies, Technegas particles have an advantage over radiolabeled liquid aerosols due to the better penetration to the periphery. Radiolabeled macro aggregated human albumin (MAA) is the imaging agent of choice for perfusion scintigraphy. The method allows recognition of V/P pattern typical for PE, the sign of chronic obstructive pulmonary disease (COPD), pneumonia, left heart failure (LHF), chronic PE, and suspicion of other parenchymal processes like tumors. It gives a clear answer to the clinicians regarding PE. Furthermore, it is possible to quantify the extent of ventilation and perfusion changes. The radiation exposure is low, the sensitivity and specificity are above 95% and the method has no contraindications. It is possible to diagnose PE even in the presence of another pulmonary comorbidity. Hybrid V/P SPECT/CT might have additional value for tumor diagnostics.

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Please use this url to cite or link to this publication:
author
and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
COPD, CTPA, Functional imaging, HYBRID V/P SPECT/CT, Pneumonia, Pulmonary embolism, V/P SPECT
host publication
Nuclear Medicine and Molecular Imaging : Volume 1-4 - Volume 1-4
volume
2
pages
11 pages
publisher
Elsevier
external identifiers
  • scopus:85151175571
ISBN
9780128229606
9780128229804
DOI
10.1016/B978-0-12-822960-6.00023-5
language
English
LU publication?
yes
id
b25c727e-129d-4c16-b79b-dc68d48ca183
date added to LUP
2023-05-30 10:01:00
date last changed
2025-02-09 03:38:03
@inbook{b25c727e-129d-4c16-b79b-dc68d48ca183,
  abstract     = {{<p>Ventilation/perfusion single photon emission computed tomography (V/P SPECT) is the recommended method for proper diagnosis of pulmonary embolism (PE), according to the European Association of Nuclear Medicine (EANM) guidelines. Adequate V/P SPECT acquisition starts with ventilation and continues immediately with perfusion. The whole procedure takes 20min by using an optimal combination of nuclide activities, collimators, and imaging matrix. For the ventilation studies, Technegas particles have an advantage over radiolabeled liquid aerosols due to the better penetration to the periphery. Radiolabeled macro aggregated human albumin (MAA) is the imaging agent of choice for perfusion scintigraphy. The method allows recognition of V/P pattern typical for PE, the sign of chronic obstructive pulmonary disease (COPD), pneumonia, left heart failure (LHF), chronic PE, and suspicion of other parenchymal processes like tumors. It gives a clear answer to the clinicians regarding PE. Furthermore, it is possible to quantify the extent of ventilation and perfusion changes. The radiation exposure is low, the sensitivity and specificity are above 95% and the method has no contraindications. It is possible to diagnose PE even in the presence of another pulmonary comorbidity. Hybrid V/P SPECT/CT might have additional value for tumor diagnostics.</p>}},
  author       = {{Bajc, Marika and Lindqvist, Ari}},
  booktitle    = {{Nuclear Medicine and Molecular Imaging : Volume 1-4}},
  isbn         = {{9780128229606}},
  keywords     = {{COPD; CTPA; Functional imaging; HYBRID V/P SPECT/CT; Pneumonia; Pulmonary embolism; V/P SPECT}},
  language     = {{eng}},
  pages        = {{92--102}},
  publisher    = {{Elsevier}},
  title        = {{Pulmonary Embolism : Ventilation/Perfusion Scintigraphy as a Proper Tool in Diagnosing Pulmonary Embolism and Frequent Pulmonary Comorbidities}},
  url          = {{http://dx.doi.org/10.1016/B978-0-12-822960-6.00023-5}},
  doi          = {{10.1016/B978-0-12-822960-6.00023-5}},
  volume       = {{2}},
  year         = {{2022}},
}