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The Complex Role of the ZNF224 Transcription Factor in Cancer

Cesaro, Elena; Sodaro, Gaetano; Montano, G. LU ; Grosso, Michela; Lupo, A. and Costanzo, Paola (2017) In Advances in Protein Chemistry and Structural Biology 107. p.191-222
Abstract

ZNF224 is a member of the Kruppel-associated box zinc finger proteins (KRAB-ZFPs) family. It was originally identified as a transcriptional repressor involved in gene-specific silencing through the recruitment of the corepressor KAP1, chromatin-modifying activities, and the arginine methyltransferase PRMT5 on the promoter of its target genes.Recent findings indicate that ZNF224 can behave both as a tumor suppressor or an oncogene in different human cancers. The transcriptional regulatory properties of ZNF224 in these systems appear to be complex and influenced by specific sets of interactors. ZNF224 can also act as a transcription cofactor for other DNA-binding proteins. A role for ZNF224 in transcriptional activation has also... (More)

ZNF224 is a member of the Kruppel-associated box zinc finger proteins (KRAB-ZFPs) family. It was originally identified as a transcriptional repressor involved in gene-specific silencing through the recruitment of the corepressor KAP1, chromatin-modifying activities, and the arginine methyltransferase PRMT5 on the promoter of its target genes.Recent findings indicate that ZNF224 can behave both as a tumor suppressor or an oncogene in different human cancers. The transcriptional regulatory properties of ZNF224 in these systems appear to be complex and influenced by specific sets of interactors. ZNF224 can also act as a transcription cofactor for other DNA-binding proteins. A role for ZNF224 in transcriptional activation has also emerged.Here, we review the state of the literature supporting both roles of ZNF224 in cancer. We also examine the functional activity of ZNF224 as a transcription factor and the influence of protein partners on its dual behavior.Increasing information on the mechanism through which ZNF224 can operate could lead to the identification of agents capable of modulating ZNF224 function, thus potentially paving the way to new therapeutic strategies for treatment of cancer.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cancer, Interacting proteins, Kruppel-associated box zinc finger proteins, Oncogene, Oncosuppressor, Transcriptional complex, ZNF224
in
Advances in Protein Chemistry and Structural Biology
volume
107
pages
191 - 222
publisher
Academic Press
external identifiers
  • scopus:85007495062
  • wos:000405230200007
ISSN
1876-1623
DOI
10.1016/bs.apcsb.2016.11.003
language
English
LU publication?
yes
id
b2686666-aed4-4afd-a07c-a2aaf64a91b6
date added to LUP
2017-02-24 10:09:52
date last changed
2018-01-21 04:19:50
@article{b2686666-aed4-4afd-a07c-a2aaf64a91b6,
  abstract     = {<p>ZNF224 is a member of the Kruppel-associated box zinc finger proteins (KRAB-ZFPs) family. It was originally identified as a transcriptional repressor involved in gene-specific silencing through the recruitment of the corepressor KAP1, chromatin-modifying activities, and the arginine methyltransferase PRMT5 on the promoter of its target genes.Recent findings indicate that ZNF224 can behave both as a tumor suppressor or an oncogene in different human cancers. The transcriptional regulatory properties of ZNF224 in these systems appear to be complex and influenced by specific sets of interactors. ZNF224 can also act as a transcription cofactor for other DNA-binding proteins. A role for ZNF224 in transcriptional activation has also emerged.Here, we review the state of the literature supporting both roles of ZNF224 in cancer. We also examine the functional activity of ZNF224 as a transcription factor and the influence of protein partners on its dual behavior.Increasing information on the mechanism through which ZNF224 can operate could lead to the identification of agents capable of modulating ZNF224 function, thus potentially paving the way to new therapeutic strategies for treatment of cancer.</p>},
  author       = {Cesaro, Elena and Sodaro, Gaetano and Montano, G. and Grosso, Michela and Lupo, A. and Costanzo, Paola},
  issn         = {1876-1623},
  keyword      = {Cancer,Interacting proteins,Kruppel-associated box zinc finger proteins,Oncogene,Oncosuppressor,Transcriptional complex,ZNF224},
  language     = {eng},
  pages        = {191--222},
  publisher    = {Academic Press},
  series       = {Advances in Protein Chemistry and Structural Biology},
  title        = {The Complex Role of the ZNF224 Transcription Factor in Cancer},
  url          = {http://dx.doi.org/10.1016/bs.apcsb.2016.11.003},
  volume       = {107},
  year         = {2017},
}