Effects of TCF7L2 rs7903146 variant on metformin response in patients with type 2 diabetes
(2019) In Bosnian Journal of Basic Medical Sciences 19(4). p.368-374- Abstract
The response to metformin, the most commonly used drug for the treatment of type 2 diabetes (T2D), is highly variable. The common variant rs7903146 C>T within the transcription factor 7-like 2 gene (TCF7L2) is the strongest genetic risk factor associated with T2D to date. In this study, we explored the effects of the TCF7L2 rs7903146 genotype on metformin response in T2D. The study included 86 newly diagnosed patients with T2D, incident users of metformin. Levels of fasting glucose, insulin, HbA1c, total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides, and anthropometric parameters were measured prior to metformin therapy, and 6 and 12 months after the treatment. Genotyping of the TCF7L2 rs7903146 was... (More)
The response to metformin, the most commonly used drug for the treatment of type 2 diabetes (T2D), is highly variable. The common variant rs7903146 C>T within the transcription factor 7-like 2 gene (TCF7L2) is the strongest genetic risk factor associated with T2D to date. In this study, we explored the effects of the TCF7L2 rs7903146 genotype on metformin response in T2D. The study included 86 newly diagnosed patients with T2D, incident users of metformin. Levels of fasting glucose, insulin, HbA1c, total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides, and anthropometric parameters were measured prior to metformin therapy, and 6 and 12 months after the treatment. Genotyping of the TCF7L2 rs7903146 was performed by the Sequenom MassARRAY® iPLEX® platform. At baseline, the diabetes risk allele (T) showed an association with lower triglyceride levels (p = 0.037). After 12 months of metformin treatment, the T allele was associated with 25.9% lower fasting insulin levels (95% CI 10.9-38.3%, p = 0.002) and 29.1% lower HOMA-IR index (95% CI 10.1-44.1%, p = 0.005), after adjustment for baseline values. Moreover, the T allele was associated with 6.7% lower fasting glucose levels (95% CI 1.1-12.0%, p = 0.021), adjusted for baseline glucose and baseline HOMA-%B levels, after 6 months of metformin treatment. This effect was more pronounced in the TT carriers who had 16.8% lower fasting glucose levels (95% CI 7.0-25.6%, p = 0.002) compared to the patients with CC genotype. Our results suggest that the TCF7L2 rs7903146 variant affects markers of insulin resistance and glycemic response to metformin in newly diagnosed patients with T2D within the first year of metformin treatment.
(Less)
- author
- Dujic, Tanja ; Bego, Tamer ; Malenica, Maja ; Velija-Asimi, Zelija ; Ahlqvist, Emma LU ; Groop, Leif LU ; Pearson, Ewan R. LU ; Causevic, Adlija and Semiz, Sabina
- organization
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Metformin, Pharmacogenetics, TCF7L2, Transcription factor 7-like 2 gene, Type 2 diabetes
- in
- Bosnian Journal of Basic Medical Sciences
- volume
- 19
- issue
- 4
- pages
- 368 - 374
- publisher
- Association of Basic Medical Sciences Federation of Bosnia and Herzegovina
- external identifiers
-
- scopus:85074743887
- pmid:31070566
- ISSN
- 1512-8601
- DOI
- 10.17305/bjbms.2019.4181
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2019, Association of Basic Medical Sciences of FBIH. All rights reserved.
- id
- b28cbe74-33ca-4ab5-9891-09e6bb4ba438
- date added to LUP
- 2021-12-21 12:50:01
- date last changed
- 2024-04-20 18:12:57
@article{b28cbe74-33ca-4ab5-9891-09e6bb4ba438,
abstract = {{<p>The response to metformin, the most commonly used drug for the treatment of type 2 diabetes (T2D), is highly variable. The common variant rs7903146 C>T within the transcription factor 7-like 2 gene (TCF7L2) is the strongest genetic risk factor associated with T2D to date. In this study, we explored the effects of the TCF7L2 rs7903146 genotype on metformin response in T2D. The study included 86 newly diagnosed patients with T2D, incident users of metformin. Levels of fasting glucose, insulin, HbA<sub>1c</sub>, total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides, and anthropometric parameters were measured prior to metformin therapy, and 6 and 12 months after the treatment. Genotyping of the TCF7L2 rs7903146 was performed by the Sequenom MassARRAY® iPLEX® platform. At baseline, the diabetes risk allele (T) showed an association with lower triglyceride levels (p = 0.037). After 12 months of metformin treatment, the T allele was associated with 25.9% lower fasting insulin levels (95% CI 10.9-38.3%, p = 0.002) and 29.1% lower HOMA-IR index (95% CI 10.1-44.1%, p = 0.005), after adjustment for baseline values. Moreover, the T allele was associated with 6.7% lower fasting glucose levels (95% CI 1.1-12.0%, p = 0.021), adjusted for baseline glucose and baseline HOMA-%B levels, after 6 months of metformin treatment. This effect was more pronounced in the TT carriers who had 16.8% lower fasting glucose levels (95% CI 7.0-25.6%, p = 0.002) compared to the patients with CC genotype. Our results suggest that the TCF7L2 rs7903146 variant affects markers of insulin resistance and glycemic response to metformin in newly diagnosed patients with T2D within the first year of metformin treatment.</p>}},
author = {{Dujic, Tanja and Bego, Tamer and Malenica, Maja and Velija-Asimi, Zelija and Ahlqvist, Emma and Groop, Leif and Pearson, Ewan R. and Causevic, Adlija and Semiz, Sabina}},
issn = {{1512-8601}},
keywords = {{Metformin; Pharmacogenetics; TCF7L2; Transcription factor 7-like 2 gene; Type 2 diabetes}},
language = {{eng}},
number = {{4}},
pages = {{368--374}},
publisher = {{Association of Basic Medical Sciences Federation of Bosnia and Herzegovina}},
series = {{Bosnian Journal of Basic Medical Sciences}},
title = {{Effects of TCF7L2 rs7903146 variant on metformin response in patients with type 2 diabetes}},
url = {{http://dx.doi.org/10.17305/bjbms.2019.4181}},
doi = {{10.17305/bjbms.2019.4181}},
volume = {{19}},
year = {{2019}},
}