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Insulin secretion and action in North Indian women during pregnancy

Arora, G. P. LU ; Almgren, P LU ; Thaman, R. G.; Pal, A.; Groop, Leif LU ; Vaag, A LU ; Prasad, R B LU and Brøns, Charlotte (2017) In Diabetic medicine : a journal of the British Diabetic Association
Abstract

AIM: The relative roles(s) of impaired insulin secretion vs. insulin resistance in the development of gestational diabetes mellitus depend upon multiple risk factors and diagnostic criteria. Here, we explored their relative contribution to gestational diabetes as defined by the WHO 1999 (GDM1999) and adapted WHO 2013 (GDM2013) criteria, excluding the 1-h glucose value, in a high-risk Indian population from Punjab.

METHODS: Insulin secretion (HOMA2-B) and insulin action (HOMA2-IR) were assessed in 4665 Indian women with or without gestational diabetes defined by the GDM1999 or adapted GDM2013 criteria.

RESULTS: Gestational diabetes defined using both criteria was associated with decreased insulin secretion compared with... (More)

AIM: The relative roles(s) of impaired insulin secretion vs. insulin resistance in the development of gestational diabetes mellitus depend upon multiple risk factors and diagnostic criteria. Here, we explored their relative contribution to gestational diabetes as defined by the WHO 1999 (GDM1999) and adapted WHO 2013 (GDM2013) criteria, excluding the 1-h glucose value, in a high-risk Indian population from Punjab.

METHODS: Insulin secretion (HOMA2-B) and insulin action (HOMA2-IR) were assessed in 4665 Indian women with or without gestational diabetes defined by the GDM1999 or adapted GDM2013 criteria.

RESULTS: Gestational diabetes defined using both criteria was associated with decreased insulin secretion compared with pregnant women with normal glucose tolerance. Women with gestational diabetes defined by the adapted GDM2013, but not GDM1999 criteria, were more insulin resistant than pregnant women with normal glucose tolerance, and furthermore displayed lower insulin secretion than GDM1999 women. Urban habitat, illiteracy, high age and low BMI were independently associated with reduced insulin secretion, whereas Sikh religion, increasing age and BMI, as well as a family history of diabetes were independently associated with increased insulin resistance.

CONCLUSIONS: Gestational diabetes risk factors influence insulin secretion and action in North Indian women in a differential manner. Gestational diabetes classified using the adapted GDM2013 compared with GDM1999 criteria is associated with more severe impairments of insulin secretion and action.

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author
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Contribution to journal
publication status
epub
subject
in
Diabetic medicine : a journal of the British Diabetic Association
publisher
Wiley-Blackwell
ISSN
1464-5491
DOI
10.1111/dme.13428
language
English
LU publication?
yes
id
b2c5ef45-db82-4f3b-9cc1-4db3714a0fa5
date added to LUP
2017-09-05 23:58:18
date last changed
2017-09-07 14:21:07
@article{b2c5ef45-db82-4f3b-9cc1-4db3714a0fa5,
  abstract     = {<p>AIM: The relative roles(s) of impaired insulin secretion vs. insulin resistance in the development of gestational diabetes mellitus depend upon multiple risk factors and diagnostic criteria. Here, we explored their relative contribution to gestational diabetes as defined by the WHO 1999 (GDM1999) and adapted WHO 2013 (GDM2013) criteria, excluding the 1-h glucose value, in a high-risk Indian population from Punjab.</p><p>METHODS: Insulin secretion (HOMA2-B) and insulin action (HOMA2-IR) were assessed in 4665 Indian women with or without gestational diabetes defined by the GDM1999 or adapted GDM2013 criteria.</p><p>RESULTS: Gestational diabetes defined using both criteria was associated with decreased insulin secretion compared with pregnant women with normal glucose tolerance. Women with gestational diabetes defined by the adapted GDM2013, but not GDM1999 criteria, were more insulin resistant than pregnant women with normal glucose tolerance, and furthermore displayed lower insulin secretion than GDM1999 women. Urban habitat, illiteracy, high age and low BMI were independently associated with reduced insulin secretion, whereas Sikh religion, increasing age and BMI, as well as a family history of diabetes were independently associated with increased insulin resistance.</p><p>CONCLUSIONS: Gestational diabetes risk factors influence insulin secretion and action in North Indian women in a differential manner. Gestational diabetes classified using the adapted GDM2013 compared with GDM1999 criteria is associated with more severe impairments of insulin secretion and action.</p>},
  author       = {Arora, G. P. and Almgren, P and Thaman, R. G. and Pal, A. and Groop, Leif and Vaag, A and Prasad, R B and Brøns, Charlotte},
  issn         = {1464-5491},
  language     = {eng},
  month        = {07},
  publisher    = {Wiley-Blackwell},
  series       = {Diabetic medicine : a journal of the British Diabetic Association},
  title        = {Insulin secretion and action in North Indian women during pregnancy},
  url          = {http://dx.doi.org/10.1111/dme.13428},
  year         = {2017},
}