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Shorter reproductive life span is associated with increased cardiovascular risk and total mortality in Swedish women from an observational, population-based study

Carlqvist, Emilia LU ; Johnson, Linda LU and Nilsson, Peter M. LU (2022) In Maturitas 164. p.69-75
Abstract

Objectives: Reproductive history of women is of importance to estimate cardiovascular disease (CVD) risk. One aspect of that history is the reproductive life span (RLS), the period between onset of menarche and menopause. Previous studies have indicated an increased risk associated with shorter RLS, but this has never previously been tested in Scandinavian women. Our aim was to investigate such associations in Swedish women. Study design: We used observational data from the Malmö Diet Cancer Study (MDCS), which included 12,101 middle-aged women (mean age 60 years at baseline) born between 1923 and 1945 from Malmö, Sweden. Data on reproductive history was obtained from a questionnaire. Main outcome measures: Cox regression was used to... (More)

Objectives: Reproductive history of women is of importance to estimate cardiovascular disease (CVD) risk. One aspect of that history is the reproductive life span (RLS), the period between onset of menarche and menopause. Previous studies have indicated an increased risk associated with shorter RLS, but this has never previously been tested in Scandinavian women. Our aim was to investigate such associations in Swedish women. Study design: We used observational data from the Malmö Diet Cancer Study (MDCS), which included 12,101 middle-aged women (mean age 60 years at baseline) born between 1923 and 1945 from Malmö, Sweden. Data on reproductive history was obtained from a questionnaire. Main outcome measures: Cox regression was used to estimate the association between quintiles (Q1-Q5) of RLS and incident fatal or non-fatal CVD events and total mortality during follow-up, adjusted for co-variates. Results: During a maximum of 28 years of follow-up, there were 2678 non-fatal CVD events and 5697 deaths. A shorter RLS was associated with an increased CVD risk (hazard ratio (HR) 1.19, 95 % confidence interval (CI) 1.06–1.34, p = 0.004) when comparing Q1 (RLS ≤ 32 years) with Q5 (RLS ≥ 40 years). The association remained significant when specifically controlling for history of hysterectomy and/or oophorectomy (HR 1.20, 95% CI 1.07–1.35, p = 0.002, for Q1 vs. Q5). A shorter RLS was also associated with a higher mortality risk (HR 1.21, 95% CI 1.11–1.31, p = 0.001, for Q1 vs. Q5, and HR 1.10, 95% CI 1.02–1.20, p = 0.02, for Q2 vs. Q5). Conclusion: A shorter RLS was associated with increased risk of cardiovascular events and total mortality in Swedish women.

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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cardiovascular, Epidemiology, Menarche, Menopause, Reproductive life, Women's health
in
Maturitas
volume
164
pages
7 pages
publisher
Elsevier
external identifiers
  • pmid:35810529
  • scopus:85133869600
ISSN
0378-5122
DOI
10.1016/j.maturitas.2022.06.005
language
English
LU publication?
yes
id
b2dbec0b-43f9-47cd-83f1-ca95b6bccc5a
date added to LUP
2022-09-05 14:10:00
date last changed
2025-02-07 19:25:48
@article{b2dbec0b-43f9-47cd-83f1-ca95b6bccc5a,
  abstract     = {{<p>Objectives: Reproductive history of women is of importance to estimate cardiovascular disease (CVD) risk. One aspect of that history is the reproductive life span (RLS), the period between onset of menarche and menopause. Previous studies have indicated an increased risk associated with shorter RLS, but this has never previously been tested in Scandinavian women. Our aim was to investigate such associations in Swedish women. Study design: We used observational data from the Malmö Diet Cancer Study (MDCS), which included 12,101 middle-aged women (mean age 60 years at baseline) born between 1923 and 1945 from Malmö, Sweden. Data on reproductive history was obtained from a questionnaire. Main outcome measures: Cox regression was used to estimate the association between quintiles (Q1-Q5) of RLS and incident fatal or non-fatal CVD events and total mortality during follow-up, adjusted for co-variates. Results: During a maximum of 28 years of follow-up, there were 2678 non-fatal CVD events and 5697 deaths. A shorter RLS was associated with an increased CVD risk (hazard ratio (HR) 1.19, 95 % confidence interval (CI) 1.06–1.34, p = 0.004) when comparing Q1 (RLS ≤ 32 years) with Q5 (RLS ≥ 40 years). The association remained significant when specifically controlling for history of hysterectomy and/or oophorectomy (HR 1.20, 95% CI 1.07–1.35, p = 0.002, for Q1 vs. Q5). A shorter RLS was also associated with a higher mortality risk (HR 1.21, 95% CI 1.11–1.31, p = 0.001, for Q1 vs. Q5, and HR 1.10, 95% CI 1.02–1.20, p = 0.02, for Q2 vs. Q5). Conclusion: A shorter RLS was associated with increased risk of cardiovascular events and total mortality in Swedish women.</p>}},
  author       = {{Carlqvist, Emilia and Johnson, Linda and Nilsson, Peter M.}},
  issn         = {{0378-5122}},
  keywords     = {{Cardiovascular; Epidemiology; Menarche; Menopause; Reproductive life; Women's health}},
  language     = {{eng}},
  pages        = {{69--75}},
  publisher    = {{Elsevier}},
  series       = {{Maturitas}},
  title        = {{Shorter reproductive life span is associated with increased cardiovascular risk and total mortality in Swedish women from an observational, population-based study}},
  url          = {{http://dx.doi.org/10.1016/j.maturitas.2022.06.005}},
  doi          = {{10.1016/j.maturitas.2022.06.005}},
  volume       = {{164}},
  year         = {{2022}},
}