Advanced

The immune modulator Linomide prevents neuronal death in injured peripheral nerves of the mouse

Ekström, Per LU ; Hedlund, Gunnar; Karlsson, Jenny and Andersson, Gunnar (1998) In NeuroReport 9(7). p.1337-1341
Abstract

Neuronal death after injury or disease could result from imbalanced cytokine expression. Linomide (LS-2616, quinoline-3-carboxamide), a synthetic immunomodulator with effects on cytokine production, suppresses autoimmune diseases of the nervous system. Here adult mice were pre-treated with 200 mg/kg/day of Linomide for 9 days, after which the sciatic nerves were crushed. After another 10 days of Linomide treatment the dorsal root ganglia were dissected out and stained for apoptosis, either immediately or after 2 days in culture, which increases cell death. Superior cervical ganglia were also cultured for 2 days. The Linomide pretreatment profoundly reduced (~60- 80%) the injury-induced apoptotic death of neurons and satellite cells in... (More)

Neuronal death after injury or disease could result from imbalanced cytokine expression. Linomide (LS-2616, quinoline-3-carboxamide), a synthetic immunomodulator with effects on cytokine production, suppresses autoimmune diseases of the nervous system. Here adult mice were pre-treated with 200 mg/kg/day of Linomide for 9 days, after which the sciatic nerves were crushed. After another 10 days of Linomide treatment the dorsal root ganglia were dissected out and stained for apoptosis, either immediately or after 2 days in culture, which increases cell death. Superior cervical ganglia were also cultured for 2 days. The Linomide pretreatment profoundly reduced (~60- 80%) the injury-induced apoptotic death of neurons and satellite cells in both systems. The results suggest that modulation of the inflammatory cytokine cascade is a promising road to nerve cell rescue.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Apoptosis, Cytokines, Immunomodulation, Macrophages, Nerve regeneration, Neuronal death, Neuronal survival, Peripheral nerves
in
NeuroReport
volume
9
issue
7
pages
5 pages
publisher
Lippincott Williams & Wilkins
external identifiers
  • Scopus:0032507669
ISSN
0959-4965
language
English
LU publication?
yes
id
b2f15337-4341-4f7b-93b3-dce1376d78bd
date added to LUP
2016-12-07 14:46:14
date last changed
2017-01-26 17:19:12
@article{b2f15337-4341-4f7b-93b3-dce1376d78bd,
  abstract     = {<p>Neuronal death after injury or disease could result from imbalanced cytokine expression. Linomide (LS-2616, quinoline-3-carboxamide), a synthetic immunomodulator with effects on cytokine production, suppresses autoimmune diseases of the nervous system. Here adult mice were pre-treated with 200 mg/kg/day of Linomide for 9 days, after which the sciatic nerves were crushed. After another 10 days of Linomide treatment the dorsal root ganglia were dissected out and stained for apoptosis, either immediately or after 2 days in culture, which increases cell death. Superior cervical ganglia were also cultured for 2 days. The Linomide pretreatment profoundly reduced (~60- 80%) the injury-induced apoptotic death of neurons and satellite cells in both systems. The results suggest that modulation of the inflammatory cytokine cascade is a promising road to nerve cell rescue.</p>},
  author       = {Ekström, Per and Hedlund, Gunnar and Karlsson, Jenny and Andersson, Gunnar},
  issn         = {0959-4965},
  keyword      = {Apoptosis,Cytokines,Immunomodulation,Macrophages,Nerve regeneration,Neuronal death,Neuronal survival,Peripheral nerves},
  language     = {eng},
  month        = {05},
  number       = {7},
  pages        = {1337--1341},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {NeuroReport},
  title        = {The immune modulator Linomide prevents neuronal death in injured peripheral nerves of the mouse},
  volume       = {9},
  year         = {1998},
}