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Leukocyte telomere length predicts SSRI response in major depressive disorder : A preliminary report

Hough, Christina M; Bersani, F Saverio; Mellon, Synthia H; Epel, Elissa S; Reus, Victor I; Lindqvist, Daniel LU ; Reus, Victor I; Mahan, Laura; Rosser, Rebecca and Burke, Heather, et al. (2016) In Cognitive Neuropsychiatry p.88-96
Abstract

Short leukocyte telomere length (LTL) may be associated with several psychiatric disorders, including major depressive disorder (MDD). Short LTL has previously been associated with poor response to psychiatric medications in bipolar disorder and schizophrenia, but no studies have prospectively assessed the relationship of LTL to SSRI response in MDD. We assessed pre-treatment LTL, depression severity (using the Hamilton Depression Rating Scale [HDRS]), and self-reported positive and negative affect in 27 healthy, unmedicated adults with MDD. Subjects then underwent open-label treatment with a selective serotonin reuptake inhibitor (SSRI) antidepressant for eight weeks, after which clinical ratings were repeated. Analyses were corrected... (More)

Short leukocyte telomere length (LTL) may be associated with several psychiatric disorders, including major depressive disorder (MDD). Short LTL has previously been associated with poor response to psychiatric medications in bipolar disorder and schizophrenia, but no studies have prospectively assessed the relationship of LTL to SSRI response in MDD. We assessed pre-treatment LTL, depression severity (using the Hamilton Depression Rating Scale [HDRS]), and self-reported positive and negative affect in 27 healthy, unmedicated adults with MDD. Subjects then underwent open-label treatment with a selective serotonin reuptake inhibitor (SSRI) antidepressant for eight weeks, after which clinical ratings were repeated. Analyses were corrected for age, sex and BMI. "Non-responders" to treatment (HDRS improvement <50%) had significantly shorter pre-treatment LTL, compared to "Responders" (p=0.037). Further, shorter pre-treatment LTL was associated with less improvement in negative affect (p<0.010) but not with changes in positive affect (p=0.356). This preliminary study is the first to assess the relationship between LTL and SSRI response in MDD and among the first to prospectively assess its relationship to treatment outcome in any psychiatric illness. Our data suggest that short LTL may serve as a vulnerability index of poorer response to SSRI treatment, but this needs examination in larger samples.

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Cognitive Neuropsychiatry
issue
2
pages
9 pages
publisher
Taylor & Francis
ISSN
2296-9209
DOI
10.1159/000446500
language
English
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yes
id
b30aaadb-6987-496e-a8cb-d28c5f3f7b5f
date added to LUP
2016-12-23 11:16:21
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2017-04-20 10:10:53
@article{b30aaadb-6987-496e-a8cb-d28c5f3f7b5f,
  abstract     = {<p>Short leukocyte telomere length (LTL) may be associated with several psychiatric disorders, including major depressive disorder (MDD). Short LTL has previously been associated with poor response to psychiatric medications in bipolar disorder and schizophrenia, but no studies have prospectively assessed the relationship of LTL to SSRI response in MDD. We assessed pre-treatment LTL, depression severity (using the Hamilton Depression Rating Scale [HDRS]), and self-reported positive and negative affect in 27 healthy, unmedicated adults with MDD. Subjects then underwent open-label treatment with a selective serotonin reuptake inhibitor (SSRI) antidepressant for eight weeks, after which clinical ratings were repeated. Analyses were corrected for age, sex and BMI. "Non-responders" to treatment (HDRS improvement &lt;50%) had significantly shorter pre-treatment LTL, compared to "Responders" (p=0.037). Further, shorter pre-treatment LTL was associated with less improvement in negative affect (p&lt;0.010) but not with changes in positive affect (p=0.356). This preliminary study is the first to assess the relationship between LTL and SSRI response in MDD and among the first to prospectively assess its relationship to treatment outcome in any psychiatric illness. Our data suggest that short LTL may serve as a vulnerability index of poorer response to SSRI treatment, but this needs examination in larger samples.</p>},
  author       = {Hough, Christina M and Bersani, F Saverio and Mellon, Synthia H and Epel, Elissa S and Reus, Victor I and Lindqvist, Daniel and Reus, Victor I and Mahan, Laura and Rosser, Rebecca and Burke, Heather and Coetzee, John and Nelson, J Craig and Blackburn, Elizabeth H and Wolkowitz, Owen M},
  issn         = {2296-9209},
  language     = {eng},
  number       = {2},
  pages        = {88--96},
  publisher    = {Taylor & Francis},
  series       = {Cognitive Neuropsychiatry},
  title        = {Leukocyte telomere length predicts SSRI response in major depressive disorder : A preliminary report},
  url          = {http://dx.doi.org/10.1159/000446500},
  year         = {2016},
}