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Sensitization patterns to cat molecular allergens in subjects with allergic sensitization to cat dander

Özuygur Ermis, Saliha Selin ; Norouzi, Aram ; Borres, Magnus P. ; Basna, Rani LU orcid ; Ekerljung, Linda ; Malmhäll, Carina ; Goksör, Emma ; Wennergren, Göran ; Rådinger, Madeleine and Lötvall, Jan , et al. (2023) In Clinical and Translational Allergy 13(8).
Abstract

Background: The use of molecular allergology has increasingly become common in the diagnosis and management of allergic diseases. However, there is still a lack of data on cat molecular allergens in adults. Therefore, we aimed to uncover the sensitization patterns to cat molecular allergens. Methods: Participants were recruited from the West Asthma Sweden Study, a population-based study enriched with asthma subjects aged 16–75 years. Of 1872, 361 individuals were positive for cat dander immunoglobulin E and were further analysed for cat molecular allergens (Fel d 1/2/4/7). Sensitization patterns were classified as monosensitization, polysensitization, and concomitant sensitization, and were related to demographic and clinical... (More)

Background: The use of molecular allergology has increasingly become common in the diagnosis and management of allergic diseases. However, there is still a lack of data on cat molecular allergens in adults. Therefore, we aimed to uncover the sensitization patterns to cat molecular allergens. Methods: Participants were recruited from the West Asthma Sweden Study, a population-based study enriched with asthma subjects aged 16–75 years. Of 1872, 361 individuals were positive for cat dander immunoglobulin E and were further analysed for cat molecular allergens (Fel d 1/2/4/7). Sensitization patterns were classified as monosensitization, polysensitization, and concomitant sensitization, and were related to demographic and clinical measurements. Results: Among cat-sensitized subjects, 84.2% were sensitized to secretoglobin, while 42.4% were sensitized to lipocalins. Nearly half of the subjects were monosensitized to Fel d 1. Polysensitization was observed in 20.2%, and concomitant sensitization to protein families was seen in 7.2%. Asthma prevalence, cat exposure, and rural living were associated with poly- and concomitant sensitization to protein families. Concomitant sensitization to single allergens was more common in those with asthma than in those without, while concomitant sensitization to both Fel d 1 and Fel d 4 was the most common pattern in individuals with asthma. Sensitization patterns also differed according to cat ownership and the degree of urbanization. Conclusion: Sensitization to molecular allergens was observed in 90.9% of cat-sensitized subjects and showed variations across participants' background characteristics and the presence of asthma. Identification of sensitization patterns to cat allergens might provide better characterization of cat-allergic subjects.

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publishing date
type
Contribution to journal
publication status
published
subject
keywords
allergic sensitization
in
Clinical and Translational Allergy
volume
13
issue
8
article number
e12294
publisher
BioMed Central (BMC)
external identifiers
  • pmid:37632243
  • scopus:85167905581
ISSN
2045-7022
DOI
10.1002/clt2.12294
language
English
LU publication?
no
additional info
Publisher Copyright: © 2023 The Authors. Clinical and Translational Allergy published by John Wiley & Sons Ltd on behalf of European Academy of Allergy and Clinical Immunology.
id
b327614e-ec7d-4a2f-9a32-841b7137d190
date added to LUP
2024-06-03 09:03:47
date last changed
2024-07-01 10:31:51
@article{b327614e-ec7d-4a2f-9a32-841b7137d190,
  abstract     = {{<p>Background: The use of molecular allergology has increasingly become common in the diagnosis and management of allergic diseases. However, there is still a lack of data on cat molecular allergens in adults. Therefore, we aimed to uncover the sensitization patterns to cat molecular allergens. Methods: Participants were recruited from the West Asthma Sweden Study, a population-based study enriched with asthma subjects aged 16–75 years. Of 1872, 361 individuals were positive for cat dander immunoglobulin E and were further analysed for cat molecular allergens (Fel d 1/2/4/7). Sensitization patterns were classified as monosensitization, polysensitization, and concomitant sensitization, and were related to demographic and clinical measurements. Results: Among cat-sensitized subjects, 84.2% were sensitized to secretoglobin, while 42.4% were sensitized to lipocalins. Nearly half of the subjects were monosensitized to Fel d 1. Polysensitization was observed in 20.2%, and concomitant sensitization to protein families was seen in 7.2%. Asthma prevalence, cat exposure, and rural living were associated with poly- and concomitant sensitization to protein families. Concomitant sensitization to single allergens was more common in those with asthma than in those without, while concomitant sensitization to both Fel d 1 and Fel d 4 was the most common pattern in individuals with asthma. Sensitization patterns also differed according to cat ownership and the degree of urbanization. Conclusion: Sensitization to molecular allergens was observed in 90.9% of cat-sensitized subjects and showed variations across participants' background characteristics and the presence of asthma. Identification of sensitization patterns to cat allergens might provide better characterization of cat-allergic subjects.</p>}},
  author       = {{Özuygur Ermis, Saliha Selin and Norouzi, Aram and Borres, Magnus P. and Basna, Rani and Ekerljung, Linda and Malmhäll, Carina and Goksör, Emma and Wennergren, Göran and Rådinger, Madeleine and Lötvall, Jan and Kankaanranta, Hannu and Nwaru, Bright I.}},
  issn         = {{2045-7022}},
  keywords     = {{allergic sensitization}},
  language     = {{eng}},
  number       = {{8}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{Clinical and Translational Allergy}},
  title        = {{Sensitization patterns to cat molecular allergens in subjects with allergic sensitization to cat dander}},
  url          = {{http://dx.doi.org/10.1002/clt2.12294}},
  doi          = {{10.1002/clt2.12294}},
  volume       = {{13}},
  year         = {{2023}},
}