A new approach to detection of antigen-antibody complexes by microcalorimetric measurements of heat production in blood cells
(1980) In Journal of Immunological Methods 37(1). p.29-37- Abstract
Using batch microcalorimeters of the thermopile conduction type, heat production was measured in human blood in the presence of defined antigens and their specific antibodies. A large increase in heat production, reflecting increased metabolic activity in the blood cells, was found when antigens and specific antisera at certain antigen-antibody proportions were mixed with the blood. The reproducibility and specificity of the method were found to be very good. The present results indicate that calorimetry may be a useful technique for detection of antigen-antibody complexes.
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- author
- Monti, M. ; Fäldt, R. LU ; Ankerst, J. LU and Wadsö, I. LU
- organization
- publishing date
- 1980
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Immunological Methods
- volume
- 37
- issue
- 1
- pages
- 29 - 37
- publisher
- Elsevier
- external identifiers
-
- pmid:7430659
- scopus:0018964686
- ISSN
- 0022-1759
- DOI
- 10.1016/0022-1759(80)90178-7
- language
- English
- LU publication?
- yes
- id
- b342d9a4-cd3e-485d-8fa0-9298b35559cc
- date added to LUP
- 2021-01-21 15:42:13
- date last changed
- 2024-01-03 05:36:54
@article{b342d9a4-cd3e-485d-8fa0-9298b35559cc, abstract = {{<p>Using batch microcalorimeters of the thermopile conduction type, heat production was measured in human blood in the presence of defined antigens and their specific antibodies. A large increase in heat production, reflecting increased metabolic activity in the blood cells, was found when antigens and specific antisera at certain antigen-antibody proportions were mixed with the blood. The reproducibility and specificity of the method were found to be very good. The present results indicate that calorimetry may be a useful technique for detection of antigen-antibody complexes.</p>}}, author = {{Monti, M. and Fäldt, R. and Ankerst, J. and Wadsö, I.}}, issn = {{0022-1759}}, language = {{eng}}, number = {{1}}, pages = {{29--37}}, publisher = {{Elsevier}}, series = {{Journal of Immunological Methods}}, title = {{A new approach to detection of antigen-antibody complexes by microcalorimetric measurements of heat production in blood cells}}, url = {{http://dx.doi.org/10.1016/0022-1759(80)90178-7}}, doi = {{10.1016/0022-1759(80)90178-7}}, volume = {{37}}, year = {{1980}}, }