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A new approach to detection of antigen-antibody complexes by microcalorimetric measurements of heat production in blood cells

Monti, M. ; Fäldt, R. LU ; Ankerst, J. LU orcid and Wadsö, I. LU (1980) In Journal of Immunological Methods 37(1). p.29-37
Abstract

Using batch microcalorimeters of the thermopile conduction type, heat production was measured in human blood in the presence of defined antigens and their specific antibodies. A large increase in heat production, reflecting increased metabolic activity in the blood cells, was found when antigens and specific antisera at certain antigen-antibody proportions were mixed with the blood. The reproducibility and specificity of the method were found to be very good. The present results indicate that calorimetry may be a useful technique for detection of antigen-antibody complexes.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Immunological Methods
volume
37
issue
1
pages
29 - 37
publisher
Elsevier
external identifiers
  • scopus:0018964686
  • pmid:7430659
ISSN
0022-1759
DOI
10.1016/0022-1759(80)90178-7
language
English
LU publication?
yes
id
b342d9a4-cd3e-485d-8fa0-9298b35559cc
date added to LUP
2021-01-21 15:42:13
date last changed
2025-10-14 11:32:39
@article{b342d9a4-cd3e-485d-8fa0-9298b35559cc,
  abstract     = {{<p>Using batch microcalorimeters of the thermopile conduction type, heat production was measured in human blood in the presence of defined antigens and their specific antibodies. A large increase in heat production, reflecting increased metabolic activity in the blood cells, was found when antigens and specific antisera at certain antigen-antibody proportions were mixed with the blood. The reproducibility and specificity of the method were found to be very good. The present results indicate that calorimetry may be a useful technique for detection of antigen-antibody complexes.</p>}},
  author       = {{Monti, M. and Fäldt, R. and Ankerst, J. and Wadsö, I.}},
  issn         = {{0022-1759}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{29--37}},
  publisher    = {{Elsevier}},
  series       = {{Journal of Immunological Methods}},
  title        = {{A new approach to detection of antigen-antibody complexes by microcalorimetric measurements of heat production in blood cells}},
  url          = {{http://dx.doi.org/10.1016/0022-1759(80)90178-7}},
  doi          = {{10.1016/0022-1759(80)90178-7}},
  volume       = {{37}},
  year         = {{1980}},
}