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Do natural antibodies compensate for humoral immunosenescence in tropical pythons?

Ujvari, Beata and Madsen, Thomas LU (2011) In Functional Ecology 25(4). p.813-817
Abstract
1. Ageing is frequently claimed to result in an age-dependent deterioration in immune function. 2. Our results, however, based on 30 known-aged water pythons (Liasis fuscus; age ranging from <1 to 18 years) immunized with keyhole limpet haemocyanin (KLH), demonstrate that age-related changes in immune function may follow different and opposing pathways. 3. Python-specific humoral antibodies (SpAb) showed an age-dependent decrease in cross-reactivity to KLH, whereas natural antibodies (NAbs) ability to bind to this antigen increased with age. 4. Notably, when humoral SpAb and NAb titres were combined, no effect of age was detected in antibody cross-reactivity, strongly suggesting that NAbs may play a crucial role in maintaining... (More)
1. Ageing is frequently claimed to result in an age-dependent deterioration in immune function. 2. Our results, however, based on 30 known-aged water pythons (Liasis fuscus; age ranging from <1 to 18 years) immunized with keyhole limpet haemocyanin (KLH), demonstrate that age-related changes in immune function may follow different and opposing pathways. 3. Python-specific humoral antibodies (SpAb) showed an age-dependent decrease in cross-reactivity to KLH, whereas natural antibodies (NAbs) ability to bind to this antigen increased with age. 4. Notably, when humoral SpAb and NAb titres were combined, no effect of age was detected in antibody cross-reactivity, strongly suggesting that NAbs may play a crucial role in maintaining immunocompetence during the ageing process. (Less)
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author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
ageing, humoral immune response, immunosenescence, KLH, natural, antibodies, snake
in
Functional Ecology
volume
25
issue
4
pages
813 - 817
publisher
Wiley-Blackwell
external identifiers
  • wos:000292330000010
  • scopus:79959812419
ISSN
1365-2435
DOI
10.1111/j.1365-2435.2011.01860.x
language
English
LU publication?
yes
id
b3555b80-dc98-47c7-b0f8-da85726a7391 (old id 2032299)
date added to LUP
2016-04-01 09:52:10
date last changed
2025-04-04 15:24:15
@article{b3555b80-dc98-47c7-b0f8-da85726a7391,
  abstract     = {{1. Ageing is frequently claimed to result in an age-dependent deterioration in immune function. 2. Our results, however, based on 30 known-aged water pythons (Liasis fuscus; age ranging from &lt;1 to 18 years) immunized with keyhole limpet haemocyanin (KLH), demonstrate that age-related changes in immune function may follow different and opposing pathways. 3. Python-specific humoral antibodies (SpAb) showed an age-dependent decrease in cross-reactivity to KLH, whereas natural antibodies (NAbs) ability to bind to this antigen increased with age. 4. Notably, when humoral SpAb and NAb titres were combined, no effect of age was detected in antibody cross-reactivity, strongly suggesting that NAbs may play a crucial role in maintaining immunocompetence during the ageing process.}},
  author       = {{Ujvari, Beata and Madsen, Thomas}},
  issn         = {{1365-2435}},
  keywords     = {{ageing; humoral immune response; immunosenescence; KLH; natural; antibodies; snake}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{813--817}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Functional Ecology}},
  title        = {{Do natural antibodies compensate for humoral immunosenescence in tropical pythons?}},
  url          = {{http://dx.doi.org/10.1111/j.1365-2435.2011.01860.x}},
  doi          = {{10.1111/j.1365-2435.2011.01860.x}},
  volume       = {{25}},
  year         = {{2011}},
}