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Ny subtyp av molluscipoxvirus påvisad : Modern teknik identifierar nya och ovanliga patogener snabbare

Hammarin, Anna Lena; Eklund, Yvonne LU ; Karlberg, Maria LU ; Bogh, Morten LU and Sikora, Per (2016) In Lakartidningen 113(48). p.1-4
Abstract

Molluscum contagiosum is a viral infection of the epidermis characterized by skin-colored papules or nodules frequently with a central depression. Atypical variants may occur, primarily in immunosuppressed individuals. We here report a case of »giant Molluscum contagiosum« in an immunocompetent child. The patient was presented with a fairly smooth nodule of 2 cm in diameter on the ring finger. Molluscipoxvirus-like virus particles were detected by electron microscopy from the nodule, but since the clinical picture was not compatible with MC, next generation sequencing was performed in order to verify the diagnosis. Of the total number of obtained sequences, 25% belonged to molluscipoxvirus (MCV) and de novo assembly revealed three... (More)

Molluscum contagiosum is a viral infection of the epidermis characterized by skin-colored papules or nodules frequently with a central depression. Atypical variants may occur, primarily in immunosuppressed individuals. We here report a case of »giant Molluscum contagiosum« in an immunocompetent child. The patient was presented with a fairly smooth nodule of 2 cm in diameter on the ring finger. Molluscipoxvirus-like virus particles were detected by electron microscopy from the nodule, but since the clinical picture was not compatible with MC, next generation sequencing was performed in order to verify the diagnosis. Of the total number of obtained sequences, 25% belonged to molluscipoxvirus (MCV) and de novo assembly revealed three contigs corresponding to 95% of the MCV genome. The assembled genome was compared to previously published sequences of the »major envelope protein« used for genotyping of MCV genus. Several unique single nucleotide polymorphisms were identified, which led us to classify this virus as a new subtype of MCV.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Lakartidningen
volume
113
issue
48
pages
4 pages
external identifiers
  • scopus:85006051863
ISSN
0023-7205
language
Swedish
LU publication?
yes
id
b3713bbf-46f0-45ff-b02c-c932ab50fe27
date added to LUP
2016-12-30 13:02:39
date last changed
2017-11-14 09:56:06
@article{b3713bbf-46f0-45ff-b02c-c932ab50fe27,
  abstract     = {<p>Molluscum contagiosum is a viral infection of the epidermis characterized by skin-colored papules or nodules frequently with a central depression. Atypical variants may occur, primarily in immunosuppressed individuals. We here report a case of »giant Molluscum contagiosum« in an immunocompetent child. The patient was presented with a fairly smooth nodule of 2 cm in diameter on the ring finger. Molluscipoxvirus-like virus particles were detected by electron microscopy from the nodule, but since the clinical picture was not compatible with MC, next generation sequencing was performed in order to verify the diagnosis. Of the total number of obtained sequences, 25% belonged to molluscipoxvirus (MCV) and de novo assembly revealed three contigs corresponding to 95% of the MCV genome. The assembled genome was compared to previously published sequences of the »major envelope protein« used for genotyping of MCV genus. Several unique single nucleotide polymorphisms were identified, which led us to classify this virus as a new subtype of MCV.</p>},
  author       = {Hammarin, Anna Lena and Eklund, Yvonne and Karlberg, Maria and Bogh, Morten and Sikora, Per},
  issn         = {0023-7205},
  language     = {swe},
  number       = {48},
  pages        = {1--4},
  series       = {Lakartidningen},
  title        = {Ny subtyp av molluscipoxvirus påvisad : Modern teknik identifierar nya och ovanliga patogener snabbare},
  volume       = {113},
  year         = {2016},
}