Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Genome structure and dynamics of the yeast pathogen Candida glabrata

Ahmad, Khadija Mohamed LU ; Kokosar, Janez LU ; Guo, Xiaoxian ; Gu, Zhenglong ; Ishchuk, Olena LU and Piskur, Jure LU (2014) In FEMS Yeast Research 14(4). p.529-535
Abstract
The yeast pathogen Candida glabrata is the second most frequent cause of Candida infections. However, from the phylogenetic point of view, C. glabrata is much closer to Saccharomyces cerevisiae than to Candida albicans. Apparently, this yeast has relatively recently changed its life style and become a successful opportunistic pathogen. Recently, several C. glabrata sister-species, among them clinical and environmental isolates, have had their genomes characterized. Also, hundreds of C. glabrata clinical isolates have been characterized for their genomes. These isolates display enormous genomic plasticity. The number and size of chromosomes vary drastically, as well as intra- and inter-chromosomal segmental duplications occur frequently.... (More)
The yeast pathogen Candida glabrata is the second most frequent cause of Candida infections. However, from the phylogenetic point of view, C. glabrata is much closer to Saccharomyces cerevisiae than to Candida albicans. Apparently, this yeast has relatively recently changed its life style and become a successful opportunistic pathogen. Recently, several C. glabrata sister-species, among them clinical and environmental isolates, have had their genomes characterized. Also, hundreds of C. glabrata clinical isolates have been characterized for their genomes. These isolates display enormous genomic plasticity. The number and size of chromosomes vary drastically, as well as intra- and inter-chromosomal segmental duplications occur frequently. The observed genome alterations could affect phenotypic properties and thus help to adapt to the highly variable and harsh habitats this yeast finds in different human patients and their tissues. Further genome sequencing of pathogenic isolates will provide a valuable tool to understand the mechanisms behind genome dynamics and help to elucidate the genes contributing to the virulence potential. (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
genome rearrangements, chromosome polymorphism, Candida, pathogenic yeast, virulence genes
in
FEMS Yeast Research
volume
14
issue
4
pages
529 - 535
publisher
Oxford University Press
external identifiers
  • pmid:24528571
  • wos:000337584500002
  • scopus:84902087196
  • pmid:24528571
ISSN
1567-1364
DOI
10.1111/1567-1364.12145
language
English
LU publication?
yes
id
b37b1fe6-52c7-4367-96aa-fc86f1de14c3 (old id 4334620)
date added to LUP
2016-04-01 10:27:59
date last changed
2022-04-04 18:24:56
@article{b37b1fe6-52c7-4367-96aa-fc86f1de14c3,
  abstract     = {{The yeast pathogen Candida glabrata is the second most frequent cause of Candida infections. However, from the phylogenetic point of view, C. glabrata is much closer to Saccharomyces cerevisiae than to Candida albicans. Apparently, this yeast has relatively recently changed its life style and become a successful opportunistic pathogen. Recently, several C. glabrata sister-species, among them clinical and environmental isolates, have had their genomes characterized. Also, hundreds of C. glabrata clinical isolates have been characterized for their genomes. These isolates display enormous genomic plasticity. The number and size of chromosomes vary drastically, as well as intra- and inter-chromosomal segmental duplications occur frequently. The observed genome alterations could affect phenotypic properties and thus help to adapt to the highly variable and harsh habitats this yeast finds in different human patients and their tissues. Further genome sequencing of pathogenic isolates will provide a valuable tool to understand the mechanisms behind genome dynamics and help to elucidate the genes contributing to the virulence potential.}},
  author       = {{Ahmad, Khadija Mohamed and Kokosar, Janez and Guo, Xiaoxian and Gu, Zhenglong and Ishchuk, Olena and Piskur, Jure}},
  issn         = {{1567-1364}},
  keywords     = {{genome rearrangements; chromosome polymorphism; Candida; pathogenic yeast; virulence genes}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{529--535}},
  publisher    = {{Oxford University Press}},
  series       = {{FEMS Yeast Research}},
  title        = {{Genome structure and dynamics of the yeast pathogen Candida glabrata}},
  url          = {{http://dx.doi.org/10.1111/1567-1364.12145}},
  doi          = {{10.1111/1567-1364.12145}},
  volume       = {{14}},
  year         = {{2014}},
}