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gamma-trace in human pituitary adenomas

Löfberg, H LU ; Grubb, A O LU orcid ; Jörnvall, H ; Möller, C A ; Strömblad, L G LU and Olsson, S O (1984) In The Journal of clinical endocrinology and metabolism 59(1). p.8-113
Abstract

gamma-Trace, a small protein occurring in body fluids and in secretory and neuroendocrine cells, was demonstrated by immunohistochemical techniques in the cytoplasm of the tumor cells of 13 pituitary adenomas obtained at surgery and autopsy. Seven of the adenomas also contained LH immunoreactivity. FSH, TSH, and ACTH were each found in one gamma-trace-containing adenoma. gamma-Trace was also demonstrated in extracts of 1 pituitary adenoma and of 5 nontumorous adenohypophyses. The immunoreactive protein found in the extracts had a molecular weight and electrophoretic mobility characteristic of gamma-trace. Computerized amino acid sequence comparisons between the primary structure of gamma-trace and those of known hormonal peptides showed... (More)

gamma-Trace, a small protein occurring in body fluids and in secretory and neuroendocrine cells, was demonstrated by immunohistochemical techniques in the cytoplasm of the tumor cells of 13 pituitary adenomas obtained at surgery and autopsy. Seven of the adenomas also contained LH immunoreactivity. FSH, TSH, and ACTH were each found in one gamma-trace-containing adenoma. gamma-Trace was also demonstrated in extracts of 1 pituitary adenoma and of 5 nontumorous adenohypophyses. The immunoreactive protein found in the extracts had a molecular weight and electrophoretic mobility characteristic of gamma-trace. Computerized amino acid sequence comparisons between the primary structure of gamma-trace and those of known hormonal peptides showed no significant similarities.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adenoma/analysis, Adult, Aged, Amino Acid Sequence, Cystatin C, Cystatins, Electrophoresis, Polyacrylamide Gel, Female, Globulins/analysis, Histocytochemistry, Humans, Immunoenzyme Techniques, Male, Middle Aged, Pituitary Gland, Anterior/analysis, Pituitary Neoplasms/analysis
in
The Journal of clinical endocrinology and metabolism
volume
59
issue
1
pages
8 - 113
publisher
Oxford University Press
external identifiers
  • pmid:6373815
  • scopus:0021145331
ISSN
0021-972X
DOI
10.1210/jcem-59-1-113
language
English
LU publication?
yes
id
b384db94-db7c-46dd-bd05-d3b0465e85cb
date added to LUP
2021-10-25 17:38:41
date last changed
2024-01-12 02:57:05
@article{b384db94-db7c-46dd-bd05-d3b0465e85cb,
  abstract     = {{<p>gamma-Trace, a small protein occurring in body fluids and in secretory and neuroendocrine cells, was demonstrated by immunohistochemical techniques in the cytoplasm of the tumor cells of 13 pituitary adenomas obtained at surgery and autopsy. Seven of the adenomas also contained LH immunoreactivity. FSH, TSH, and ACTH were each found in one gamma-trace-containing adenoma. gamma-Trace was also demonstrated in extracts of 1 pituitary adenoma and of 5 nontumorous adenohypophyses. The immunoreactive protein found in the extracts had a molecular weight and electrophoretic mobility characteristic of gamma-trace. Computerized amino acid sequence comparisons between the primary structure of gamma-trace and those of known hormonal peptides showed no significant similarities.</p>}},
  author       = {{Löfberg, H and Grubb, A O and Jörnvall, H and Möller, C A and Strömblad, L G and Olsson, S O}},
  issn         = {{0021-972X}},
  keywords     = {{Adenoma/analysis; Adult; Aged; Amino Acid Sequence; Cystatin C; Cystatins; Electrophoresis, Polyacrylamide Gel; Female; Globulins/analysis; Histocytochemistry; Humans; Immunoenzyme Techniques; Male; Middle Aged; Pituitary Gland, Anterior/analysis; Pituitary Neoplasms/analysis}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{8--113}},
  publisher    = {{Oxford University Press}},
  series       = {{The Journal of clinical endocrinology and metabolism}},
  title        = {{gamma-trace in human pituitary adenomas}},
  url          = {{http://dx.doi.org/10.1210/jcem-59-1-113}},
  doi          = {{10.1210/jcem-59-1-113}},
  volume       = {{59}},
  year         = {{1984}},
}