Atherosclerotic plaques in the internal carotid artery and associations with lung function assessed by different methods.
(2012) In Clinical Physiology and Functional Imaging 32(2). p.120-125- Abstract
- Background: Previous studies on associations between reduced lung function and cardiovascular disease (CVD) have mainly been based on forced expiratory volume in 1-s (FEV(1) ) and vital capacity (VC). This study examined potential associations between five different lung function variables and plaques in the internal carotid artery (ICA). Methods: Subjects (n = 450) from a previous population-based respiratory questionnaire survey [current smokers without lower respiratory symptoms, subjects with a self-reported diagnosis of chronic obstructive pulmonary disease (COPD) and never-smokers without lower respiratory symptoms] were examined using spirometry, body plethysmography and measurements of diffusing capacity for CO (D(L,CO) ). Plaques... (More)
- Background: Previous studies on associations between reduced lung function and cardiovascular disease (CVD) have mainly been based on forced expiratory volume in 1-s (FEV(1) ) and vital capacity (VC). This study examined potential associations between five different lung function variables and plaques in the internal carotid artery (ICA). Methods: Subjects (n = 450) from a previous population-based respiratory questionnaire survey [current smokers without lower respiratory symptoms, subjects with a self-reported diagnosis of chronic obstructive pulmonary disease (COPD) and never-smokers without lower respiratory symptoms] were examined using spirometry, body plethysmography and measurements of diffusing capacity for CO (D(L,CO) ). Plaques in the ICA were assessed by ultrasonography. Results: Two hundred and twenty subjects were current smokers, 139 ex-smokers and 89 never-smokers. COPD was diagnosed in 130 subjects (GOLD criteria). Plaques in the ICA were present in 231 subjects (52%). General linear analysis with adjustment for established risk factors for atherosclerosis, including C-reactive protein, showed that D(L,CO) was lower [77·4% versus 83·7% of predicted normal (PN), P = 0·014] and residual volume (RV) was higher (110·3% versus 104·8% of PN, P = 0·020) in subjects with than without plaques in the ICA. This analysis did not show any statistically significant association between plaques and FEV(1) or VC. Conclusion: The occurrence of plaques in the ICA was associated with low D(L,CO) and high RV, but not significantly with FEV(1) or COPD status. The results suggest that the relationships between reduced lung function, COPD and CVD are complex and not only linked to bronchial obstruction and low-grade systemic inflammation. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2367443
- author
- Frantz, Sophia LU ; Nihlén, Ulf LU ; Dencker, Magnus LU ; Engström, Gunnar LU ; Löfdahl, Claes-Göran LU and Wollmer, Per LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Clinical Physiology and Functional Imaging
- volume
- 32
- issue
- 2
- pages
- 120 - 125
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000299734400007
- pmid:22296632
- scopus:84856412194
- pmid:22296632
- ISSN
- 1475-0961
- DOI
- 10.1111/j.1475-097X.2011.01065.x
- language
- English
- LU publication?
- yes
- id
- b39268f1-3d64-445b-a36a-6f5d40c64a83 (old id 2367443)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22296632?dopt=Abstract
- date added to LUP
- 2016-04-04 07:23:36
- date last changed
- 2023-09-05 11:52:06
@article{b39268f1-3d64-445b-a36a-6f5d40c64a83,
abstract = {{Background: Previous studies on associations between reduced lung function and cardiovascular disease (CVD) have mainly been based on forced expiratory volume in 1-s (FEV(1) ) and vital capacity (VC). This study examined potential associations between five different lung function variables and plaques in the internal carotid artery (ICA). Methods: Subjects (n = 450) from a previous population-based respiratory questionnaire survey [current smokers without lower respiratory symptoms, subjects with a self-reported diagnosis of chronic obstructive pulmonary disease (COPD) and never-smokers without lower respiratory symptoms] were examined using spirometry, body plethysmography and measurements of diffusing capacity for CO (D(L,CO) ). Plaques in the ICA were assessed by ultrasonography. Results: Two hundred and twenty subjects were current smokers, 139 ex-smokers and 89 never-smokers. COPD was diagnosed in 130 subjects (GOLD criteria). Plaques in the ICA were present in 231 subjects (52%). General linear analysis with adjustment for established risk factors for atherosclerosis, including C-reactive protein, showed that D(L,CO) was lower [77·4% versus 83·7% of predicted normal (PN), P = 0·014] and residual volume (RV) was higher (110·3% versus 104·8% of PN, P = 0·020) in subjects with than without plaques in the ICA. This analysis did not show any statistically significant association between plaques and FEV(1) or VC. Conclusion: The occurrence of plaques in the ICA was associated with low D(L,CO) and high RV, but not significantly with FEV(1) or COPD status. The results suggest that the relationships between reduced lung function, COPD and CVD are complex and not only linked to bronchial obstruction and low-grade systemic inflammation.}},
author = {{Frantz, Sophia and Nihlén, Ulf and Dencker, Magnus and Engström, Gunnar and Löfdahl, Claes-Göran and Wollmer, Per}},
issn = {{1475-0961}},
language = {{eng}},
number = {{2}},
pages = {{120--125}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Clinical Physiology and Functional Imaging}},
title = {{Atherosclerotic plaques in the internal carotid artery and associations with lung function assessed by different methods.}},
url = {{http://dx.doi.org/10.1111/j.1475-097X.2011.01065.x}},
doi = {{10.1111/j.1475-097X.2011.01065.x}},
volume = {{32}},
year = {{2012}},
}