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The future : Stem cells? Current clinical trials using stem cells for dopaminergic cell replacement

Paul, Gesine LU orcid ; Morizane, Asuka ; Kirkeby, Agnete LU ; Takahashi, Jun and Henchcliffe, Claire (2024) In International Review of Movement Disorders 7. p.191-220
Abstract

For more than a decade, stem cells have been on the horizon as a future treatment for Parkinson's disease (PD) and with this vision, it is anticipated that this novel treatment approach may be a paradigm shift in treating PD. The field has progressed enormously during the past few years and several clinical phase I/IIa trials using human embryonic stem cells or induced pluripotent stem cells as sources of dopaminergic neurons for transplantation have recently been launched.This review describes the rationale behind the concept of neural transplantation in PD, provides a comprehensive overview of the history of dopaminergic cell therapy in PD, the characteristics of the different stem cell types in question for current applications, and... (More)

For more than a decade, stem cells have been on the horizon as a future treatment for Parkinson's disease (PD) and with this vision, it is anticipated that this novel treatment approach may be a paradigm shift in treating PD. The field has progressed enormously during the past few years and several clinical phase I/IIa trials using human embryonic stem cells or induced pluripotent stem cells as sources of dopaminergic neurons for transplantation have recently been launched.This review describes the rationale behind the concept of neural transplantation in PD, provides a comprehensive overview of the history of dopaminergic cell therapy in PD, the characteristics of the different stem cell types in question for current applications, and finally provides an overview of current ongoing clinical trials in PD using dopaminergic cell replacement with cells derived from pluripotent stem cells.

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Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Cell therapy, Cell therapy clinical trial, Human embryonic stem cells, Induced pluripotent stem cells, Parkinson's disease, Transplantation
host publication
Device-Aided Therapies in Parkinson's disease
series title
International Review of Movement Disorders
volume
7
pages
30 pages
publisher
Elsevier Science Publishers B.V.
external identifiers
  • scopus:105038689196
ISSN
2666-7886
2666-7878
ISBN
978-0-443-31468-1
DOI
10.1016/bs.irmvd.2024.08.004
language
English
LU publication?
yes
id
b3d3a504-9109-4361-a565-22921e7561a7
date added to LUP
2026-08-27 15:14:46
date last changed
2026-09-24 16:53:38
@inbook{b3d3a504-9109-4361-a565-22921e7561a7,
  abstract     = {{<p>For more than a decade, stem cells have been on the horizon as a future treatment for Parkinson's disease (PD) and with this vision, it is anticipated that this novel treatment approach may be a paradigm shift in treating PD. The field has progressed enormously during the past few years and several clinical phase I/IIa trials using human embryonic stem cells or induced pluripotent stem cells as sources of dopaminergic neurons for transplantation have recently been launched.This review describes the rationale behind the concept of neural transplantation in PD, provides a comprehensive overview of the history of dopaminergic cell therapy in PD, the characteristics of the different stem cell types in question for current applications, and finally provides an overview of current ongoing clinical trials in PD using dopaminergic cell replacement with cells derived from pluripotent stem cells.</p>}},
  author       = {{Paul, Gesine and Morizane, Asuka and Kirkeby, Agnete and Takahashi, Jun and Henchcliffe, Claire}},
  booktitle    = {{Device-Aided Therapies in Parkinson's disease}},
  isbn         = {{978-0-443-31468-1}},
  issn         = {{2666-7886}},
  keywords     = {{Cell therapy; Cell therapy clinical trial; Human embryonic stem cells; Induced pluripotent stem cells; Parkinson's disease; Transplantation}},
  language     = {{eng}},
  pages        = {{191--220}},
  publisher    = {{Elsevier Science Publishers B.V.}},
  series       = {{International Review of Movement Disorders}},
  title        = {{The future : Stem cells? Current clinical trials using stem cells for dopaminergic cell replacement}},
  url          = {{http://dx.doi.org/10.1016/bs.irmvd.2024.08.004}},
  doi          = {{10.1016/bs.irmvd.2024.08.004}},
  volume       = {{7}},
  year         = {{2024}},
}