Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Development and validation of language and visuospatial composite scores in ADNI

Choi, Seo Eun ; Mukherjee, Shubhabrata ; Gibbons, Laura E. ; Sanders, R. Elizabeth ; Jones, Richard N. ; Tommet, Douglas ; Mez, Jesse ; Trittschuh, Emily H. ; Saykin, Andrew and Lamar, Melissa , et al. (2020) In Alzheimer's and Dementia: Translational Research and Clinical Interventions 6(1).
Abstract

Introduction: Composite scores may be useful to summarize overall language or visuospatial functioning in studies of older adults. Methods:We used item response theory to derive composite measures for language (ADNI-Lan) and visuospatial functioning (ADNI-VS) from the cognitive battery administered in the Alzheimer’s Disease Neuroimaging Initiative (ADNI). We evaluated the scores among groups of people with normal cognition, mild cognitive impairment (MCI), and Alzheimer’s disease (AD) in terms of responsiveness to change, association with imaging findings, and ability to differentiate between MCI participants who progressed to AD dementia and those who did not progress. Results: ADNI-Lan andADNI-VSwere able to detect change over time... (More)

Introduction: Composite scores may be useful to summarize overall language or visuospatial functioning in studies of older adults. Methods:We used item response theory to derive composite measures for language (ADNI-Lan) and visuospatial functioning (ADNI-VS) from the cognitive battery administered in the Alzheimer’s Disease Neuroimaging Initiative (ADNI). We evaluated the scores among groups of people with normal cognition, mild cognitive impairment (MCI), and Alzheimer’s disease (AD) in terms of responsiveness to change, association with imaging findings, and ability to differentiate between MCI participants who progressed to AD dementia and those who did not progress. Results: ADNI-Lan andADNI-VSwere able to detect change over time and predict conversion fromMCI toAD. Theywere associated with most of the pre-specified magnetic resonance imaging measures. ADNI-Lan had strong associations with a cerebrospinal fluid biomarker pattern. Discussion: ADNI-Lan and ADNI-VS may be useful composites for language and visuospatial functioning in ADNI.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; and (Less)
author collaboration
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alzheimer’s Disease Neuroimaging Initiative, cognition, language, longitudinal analysis, magnetic resonance imaging, psychometrics, visuospatial functioning
in
Alzheimer's and Dementia: Translational Research and Clinical Interventions
volume
6
issue
1
article number
e12072
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:85134990669
ISSN
2352-8737
DOI
10.1002/trc2.12072
language
English
LU publication?
yes
id
b3f2a617-ce43-4917-9447-1e543459016b
date added to LUP
2022-11-22 14:36:56
date last changed
2025-10-16 11:12:48
@article{b3f2a617-ce43-4917-9447-1e543459016b,
  abstract     = {{<p>Introduction: Composite scores may be useful to summarize overall language or visuospatial functioning in studies of older adults. Methods:We used item response theory to derive composite measures for language (ADNI-Lan) and visuospatial functioning (ADNI-VS) from the cognitive battery administered in the Alzheimer’s Disease Neuroimaging Initiative (ADNI). We evaluated the scores among groups of people with normal cognition, mild cognitive impairment (MCI), and Alzheimer’s disease (AD) in terms of responsiveness to change, association with imaging findings, and ability to differentiate between MCI participants who progressed to AD dementia and those who did not progress. Results: ADNI-Lan andADNI-VSwere able to detect change over time and predict conversion fromMCI toAD. Theywere associated with most of the pre-specified magnetic resonance imaging measures. ADNI-Lan had strong associations with a cerebrospinal fluid biomarker pattern. Discussion: ADNI-Lan and ADNI-VS may be useful composites for language and visuospatial functioning in ADNI.</p>}},
  author       = {{Choi, Seo Eun and Mukherjee, Shubhabrata and Gibbons, Laura E. and Sanders, R. Elizabeth and Jones, Richard N. and Tommet, Douglas and Mez, Jesse and Trittschuh, Emily H. and Saykin, Andrew and Lamar, Melissa and Rabin, Laura and Foldi, Nancy S. and Sikkes, Sietske and Jutten, Roos J. and Grandoit, Evan and MacDonald, Christine and Risacher, Shannon and Groot, Colin and Ossenkoppele, Rik and Crane, Paul K.}},
  issn         = {{2352-8737}},
  keywords     = {{Alzheimer’s Disease Neuroimaging Initiative; cognition; language; longitudinal analysis; magnetic resonance imaging; psychometrics; visuospatial functioning}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Alzheimer's and Dementia: Translational Research and Clinical Interventions}},
  title        = {{Development and validation of language and visuospatial composite scores in ADNI}},
  url          = {{http://dx.doi.org/10.1002/trc2.12072}},
  doi          = {{10.1002/trc2.12072}},
  volume       = {{6}},
  year         = {{2020}},
}