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Implications of antibiotics and antimicrobial resistance development during COVID-19 : questing genomic surveillance for a balancing act

Yadav, Vikas LU ; Yadav, Kiran ; Sehgal, Rashi and Islam, Rubina (2023) p.375-395
Abstract

The COVID-19 pandemic has jolted the health system globally and a paucity of specific drugs and/or vaccine hesitancy led clinicians to indiscriminately use antibiotics. Furthermore, during the early waves of the COVID-19 pandemic, several studies showcased the anti-SARS-CoV-2 efficacy of few antibiotics which further catapulted the idea of using them after emergency approval by the Food and Drug Authority (FDA). This nonjudicial use of antibiotics has unfortunately led to the evolution of antimicrobial resistance (AMR) as a silent pandemic. In this chapter, we describe the previous and recent studies highlighting several antibiotics that are either predicted to target the SARS-CoV-2 virus and/or shown to have efficacy in managing... (More)

The COVID-19 pandemic has jolted the health system globally and a paucity of specific drugs and/or vaccine hesitancy led clinicians to indiscriminately use antibiotics. Furthermore, during the early waves of the COVID-19 pandemic, several studies showcased the anti-SARS-CoV-2 efficacy of few antibiotics which further catapulted the idea of using them after emergency approval by the Food and Drug Authority (FDA). This nonjudicial use of antibiotics has unfortunately led to the evolution of antimicrobial resistance (AMR) as a silent pandemic. In this chapter, we describe the previous and recent studies highlighting several antibiotics that are either predicted to target the SARS-CoV-2 virus and/or shown to have efficacy in managing patients with COVID-19. We also discussed the negative implication of antibiotics during COVID-19 and why proper genomic surveillance is required to mitigate the development of AMR in the present and future pandemics.

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Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Antibiotics, Antimicrobial resistance, COVID-19, Drug repositioning, In silico drug discovery, Virus disease
host publication
Genomic Surveillance and Pandemic Preparedness
pages
21 pages
publisher
ScienceDirect, Elsevier
external identifiers
  • scopus:85166074982
ISBN
9780443187698
9780443187681
DOI
10.1016/B978-0-443-18769-8.00010-6
language
English
LU publication?
yes
id
b3fb7835-cdc8-49c1-9302-1aa86997b274
date added to LUP
2023-11-16 14:47:02
date last changed
2024-04-28 06:21:27
@inbook{b3fb7835-cdc8-49c1-9302-1aa86997b274,
  abstract     = {{<p>The COVID-19 pandemic has jolted the health system globally and a paucity of specific drugs and/or vaccine hesitancy led clinicians to indiscriminately use antibiotics. Furthermore, during the early waves of the COVID-19 pandemic, several studies showcased the anti-SARS-CoV-2 efficacy of few antibiotics which further catapulted the idea of using them after emergency approval by the Food and Drug Authority (FDA). This nonjudicial use of antibiotics has unfortunately led to the evolution of antimicrobial resistance (AMR) as a silent pandemic. In this chapter, we describe the previous and recent studies highlighting several antibiotics that are either predicted to target the SARS-CoV-2 virus and/or shown to have efficacy in managing patients with COVID-19. We also discussed the negative implication of antibiotics during COVID-19 and why proper genomic surveillance is required to mitigate the development of AMR in the present and future pandemics.</p>}},
  author       = {{Yadav, Vikas and Yadav, Kiran and Sehgal, Rashi and Islam, Rubina}},
  booktitle    = {{Genomic Surveillance and Pandemic Preparedness}},
  isbn         = {{9780443187698}},
  keywords     = {{Antibiotics; Antimicrobial resistance; COVID-19; Drug repositioning; In silico drug discovery; Virus disease}},
  language     = {{eng}},
  pages        = {{375--395}},
  publisher    = {{ScienceDirect, Elsevier}},
  title        = {{Implications of antibiotics and antimicrobial resistance development during COVID-19 : questing genomic surveillance for a balancing act}},
  url          = {{http://dx.doi.org/10.1016/B978-0-443-18769-8.00010-6}},
  doi          = {{10.1016/B978-0-443-18769-8.00010-6}},
  year         = {{2023}},
}