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Demonstration of a phospholipase A2 inhibitor in human plasma and in plasma from the European hedgehog (Erinaceus europaeus)

Lindahl, Mats ; de Wit, Cynthia ; Weström, Björn LU ; von Schenck, Henning and Tagesson, Christer (1991) In International Journal of Biochemistry 23(3). p.287-292
Abstract

1. 1. Endogenous phospholipase A2 (PLA2) inhibitors in human plasma and in plasma from the hedgehog (Erinaceus europaeus) were demonstrated. 2. 2. The PLA2 activity increased 45-fold in human plasma when a PLA2 binding factor was removed. Furthermore, two peaks of PLA2 inhibitory activity were found after DEAE-chromatography. 3. 3. High levels of PLA2 inhibitory activity was found in plasma from the European hedgehog, E. europaeus. 4. 4. The molecular weight was estimated to 140,000. 5. 5. On DEAE-chromatography two peaks were found which were chromatographically similar to the PLA2 inhibitors in human plasma.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Biochemistry
volume
23
issue
3
pages
6 pages
publisher
Elsevier
external identifiers
  • pmid:2044836
  • scopus:0025924263
ISSN
0020-711X
DOI
10.1016/0020-711X(91)90108-Y
language
English
LU publication?
yes
id
b4024025-d6f5-4053-b8e7-7b71a112b29a
date added to LUP
2024-12-05 15:21:08
date last changed
2025-10-14 11:33:48
@article{b4024025-d6f5-4053-b8e7-7b71a112b29a,
  abstract     = {{<p>1. 1. Endogenous phospholipase A<sub>2</sub> (PLA<sub>2</sub>) inhibitors in human plasma and in plasma from the hedgehog (Erinaceus europaeus) were demonstrated. 2. 2. The PLA<sub>2</sub> activity increased 45-fold in human plasma when a PLA<sub>2</sub> binding factor was removed. Furthermore, two peaks of PLA<sub>2</sub> inhibitory activity were found after DEAE-chromatography. 3. 3. High levels of PLA<sub>2</sub> inhibitory activity was found in plasma from the European hedgehog, E. europaeus. 4. 4. The molecular weight was estimated to 140,000. 5. 5. On DEAE-chromatography two peaks were found which were chromatographically similar to the PLA<sub>2</sub> inhibitors in human plasma.</p>}},
  author       = {{Lindahl, Mats and de Wit, Cynthia and Weström, Björn and von Schenck, Henning and Tagesson, Christer}},
  issn         = {{0020-711X}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{287--292}},
  publisher    = {{Elsevier}},
  series       = {{International Journal of Biochemistry}},
  title        = {{Demonstration of a phospholipase A<sub>2</sub> inhibitor in human plasma and in plasma from the European hedgehog (Erinaceus europaeus)}},
  url          = {{http://dx.doi.org/10.1016/0020-711X(91)90108-Y}},
  doi          = {{10.1016/0020-711X(91)90108-Y}},
  volume       = {{23}},
  year         = {{1991}},
}