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Vitamin K Effects on Gas6 and Soluble Axl Receptors in Intensive Care Patients : An Observational Screening Study

Schott, Ulf LU ; Augustsson, Cecilia ; Lilover, Luukas ; Ulfsdotter Nilsson, Caroline LU ; Walther-Sturesson, Louise LU and Kander, Thomas LU orcid (2021) In Nutrients 13(11).
Abstract

Growth arrest-specific gene 6 protein (Gas6) is avitamin K-dependent tissue bound protein. Gas6 has been shown to promote growth and therapy resistance among different types of cancer as well as thromboembolism. The aim of this prospective screening study: ClinicalTrials.gov; Identifier: NTC3782025, was to evaluate the effects of intravenously administered vitamin K1 on Gas6 and its soluble (s)Axl receptor plasma levels in intensive care patients. Vitamin K1 was intravenously injected in non-warfarin treated patients with prolonged Owren prothrombin time international normalized ratio (PT-INR) > 1.2 and blood samples were retrieved before and 20-28 h after injection. Citrate plasma samples from 52 intensive care patients were... (More)

Growth arrest-specific gene 6 protein (Gas6) is avitamin K-dependent tissue bound protein. Gas6 has been shown to promote growth and therapy resistance among different types of cancer as well as thromboembolism. The aim of this prospective screening study: ClinicalTrials.gov; Identifier: NTC3782025, was to evaluate the effects of intravenously administered vitamin K1 on Gas6 and its soluble (s)Axl receptor plasma levels in intensive care patients. Vitamin K1 was intravenously injected in non-warfarin treated patients with prolonged Owren prothrombin time international normalized ratio (PT-INR) > 1.2 and blood samples were retrieved before and 20-28 h after injection. Citrate plasma samples from 52 intensive care patients were analysed for different vitamin K dependent proteins. There was a significant, but small increase in median Gas6. Only one patient had a large increase in sAxl, but overall, no significant changes in sAxl Gas6 did not correlate to PT-INR, thrombin generation assay, coagulation factors II, VII, IX and X, but to protein S and decarboxylated matrix Gla protein (dp-ucMGP). In conclusion, there was a small increase in Gas6 over 20-28 h. The pathophysiology and clinical importance of this remains to be investigated. To verify a true vitamin K effect, improvement of Gas6 carboxylation defects needs to be studied.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nutrients
volume
13
issue
11
article number
4101
publisher
MDPI AG
external identifiers
  • pmid:34836355
  • pmid:34836355
  • scopus:85119042469
ISSN
2072-6643
DOI
10.3390/nu13114101
language
English
LU publication?
yes
id
b4373cbe-f382-49b7-bee4-5f8631bcb49f
date added to LUP
2021-11-17 17:41:57
date last changed
2025-04-04 14:25:56
@article{b4373cbe-f382-49b7-bee4-5f8631bcb49f,
  abstract     = {{<p>Growth arrest-specific gene 6 protein (Gas6) is avitamin K-dependent tissue bound protein. Gas6 has been shown to promote growth and therapy resistance among different types of cancer as well as thromboembolism. The aim of this prospective screening study: ClinicalTrials.gov; Identifier: NTC3782025, was to evaluate the effects of intravenously administered vitamin K1 on Gas6 and its soluble (s)Axl receptor plasma levels in intensive care patients. Vitamin K1 was intravenously injected in non-warfarin treated patients with prolonged Owren prothrombin time international normalized ratio (PT-INR) &gt; 1.2 and blood samples were retrieved before and 20-28 h after injection. Citrate plasma samples from 52 intensive care patients were analysed for different vitamin K dependent proteins. There was a significant, but small increase in median Gas6. Only one patient had a large increase in sAxl, but overall, no significant changes in sAxl Gas6 did not correlate to PT-INR, thrombin generation assay, coagulation factors II, VII, IX and X, but to protein S and decarboxylated matrix Gla protein (dp-ucMGP). In conclusion, there was a small increase in Gas6 over 20-28 h. The pathophysiology and clinical importance of this remains to be investigated. To verify a true vitamin K effect, improvement of Gas6 carboxylation defects needs to be studied.</p>}},
  author       = {{Schott, Ulf and Augustsson, Cecilia and Lilover, Luukas and Ulfsdotter Nilsson, Caroline and Walther-Sturesson, Louise and Kander, Thomas}},
  issn         = {{2072-6643}},
  language     = {{eng}},
  number       = {{11}},
  publisher    = {{MDPI AG}},
  series       = {{Nutrients}},
  title        = {{Vitamin K Effects on Gas6 and Soluble Axl Receptors in Intensive Care Patients : An Observational Screening Study}},
  url          = {{http://dx.doi.org/10.3390/nu13114101}},
  doi          = {{10.3390/nu13114101}},
  volume       = {{13}},
  year         = {{2021}},
}