Hepcidin is a relevant iron status indicator in infancy : results from a randomized trial of early vs. delayed cord clamping
(2020) In Pediatric Research- Abstract
Background: We aimed to evaluate whether serum hepcidin is a useful indicator of iron status in infants. Methods: Term infants (n = 400) were randomized to delayed (≥180 s) or early (≤10 s) cord clamping (CC). Iron status was assessed at 4 and 12 months. In all cases with iron depletion or iron deficiency (ID) (as defined in “Methods”) (n = 30) and 97 randomly selected iron-replete infants, we analyzed hepcidin and explored its correlation to the intervention, iron status, and perinatal factors. Results: Serum hepcidin concentrations were significantly lower in the early CC group at both time points and in ID infants at 4 months. Median (2.5th–97.5th percentile) hepcidin in non-ID infants in the delayed CC group (suggested reference)... (More)
Background: We aimed to evaluate whether serum hepcidin is a useful indicator of iron status in infants. Methods: Term infants (n = 400) were randomized to delayed (≥180 s) or early (≤10 s) cord clamping (CC). Iron status was assessed at 4 and 12 months. In all cases with iron depletion or iron deficiency (ID) (as defined in “Methods”) (n = 30) and 97 randomly selected iron-replete infants, we analyzed hepcidin and explored its correlation to the intervention, iron status, and perinatal factors. Results: Serum hepcidin concentrations were significantly lower in the early CC group at both time points and in ID infants at 4 months. Median (2.5th–97.5th percentile) hepcidin in non-ID infants in the delayed CC group (suggested reference) was 64.5 (10.9–142.1), 39.5 (3.5–157.7), and 32.9 (11.2–124.2) ng/mL in the cord blood and at 4 and 12 months, respectively. The value of 16 ng/mL was a threshold detecting all cases of iron depletion/ID at 4 months. No similar threshold for ID was observed at 12 months. The strongest predictor of hepcidin at both ages was ferritin. Conclusions: Hepcidin is relevant as iron status indicator in early infancy and may be useful to detect ID. Levels <16 ng/mL at 4 months of age indicates ID. Impact: Serum hepcidin is a relevant indicator of iron status in early infancy.Normal reference in healthy infants is suggested in this study.Serum hepcidin may be useful in clinical practice to detect iron deficiency.
(Less)
- author
- Berglund, Staffan K. ; Chmielewska, Anna M. ; Domellöf, Magnus and Andersson, Ola LU
- organization
- publishing date
- 2020-07-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Pediatric Research
- publisher
- International Pediatric Foundation Inc.
- external identifiers
-
- scopus:85087307303
- pmid:32610342
- ISSN
- 0031-3998
- DOI
- 10.1038/s41390-020-1045-9
- language
- English
- LU publication?
- yes
- id
- b4407332-1c00-4e5f-9055-d95ffc8105d5
- date added to LUP
- 2020-07-10 13:37:36
- date last changed
- 2024-04-17 11:59:42
@article{b4407332-1c00-4e5f-9055-d95ffc8105d5, abstract = {{<p>Background: We aimed to evaluate whether serum hepcidin is a useful indicator of iron status in infants. Methods: Term infants (n = 400) were randomized to delayed (≥180 s) or early (≤10 s) cord clamping (CC). Iron status was assessed at 4 and 12 months. In all cases with iron depletion or iron deficiency (ID) (as defined in “Methods”) (n = 30) and 97 randomly selected iron-replete infants, we analyzed hepcidin and explored its correlation to the intervention, iron status, and perinatal factors. Results: Serum hepcidin concentrations were significantly lower in the early CC group at both time points and in ID infants at 4 months. Median (2.5th–97.5th percentile) hepcidin in non-ID infants in the delayed CC group (suggested reference) was 64.5 (10.9–142.1), 39.5 (3.5–157.7), and 32.9 (11.2–124.2) ng/mL in the cord blood and at 4 and 12 months, respectively. The value of 16 ng/mL was a threshold detecting all cases of iron depletion/ID at 4 months. No similar threshold for ID was observed at 12 months. The strongest predictor of hepcidin at both ages was ferritin. Conclusions: Hepcidin is relevant as iron status indicator in early infancy and may be useful to detect ID. Levels <16 ng/mL at 4 months of age indicates ID. Impact: Serum hepcidin is a relevant indicator of iron status in early infancy.Normal reference in healthy infants is suggested in this study.Serum hepcidin may be useful in clinical practice to detect iron deficiency.</p>}}, author = {{Berglund, Staffan K. and Chmielewska, Anna M. and Domellöf, Magnus and Andersson, Ola}}, issn = {{0031-3998}}, language = {{eng}}, month = {{07}}, publisher = {{International Pediatric Foundation Inc.}}, series = {{Pediatric Research}}, title = {{Hepcidin is a relevant iron status indicator in infancy : results from a randomized trial of early vs. delayed cord clamping}}, url = {{http://dx.doi.org/10.1038/s41390-020-1045-9}}, doi = {{10.1038/s41390-020-1045-9}}, year = {{2020}}, }