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Hepcidin is a relevant iron status indicator in infancy : results from a randomized trial of early vs. delayed cord clamping

Berglund, Staffan K. ; Chmielewska, Anna M. ; Domellöf, Magnus and Andersson, Ola LU orcid (2020) In Pediatric Research
Abstract

Background: We aimed to evaluate whether serum hepcidin is a useful indicator of iron status in infants. Methods: Term infants (n = 400) were randomized to delayed (≥180 s) or early (≤10 s) cord clamping (CC). Iron status was assessed at 4 and 12 months. In all cases with iron depletion or iron deficiency (ID) (as defined in “Methods”) (n = 30) and 97 randomly selected iron-replete infants, we analyzed hepcidin and explored its correlation to the intervention, iron status, and perinatal factors. Results: Serum hepcidin concentrations were significantly lower in the early CC group at both time points and in ID infants at 4 months. Median (2.5th–97.5th percentile) hepcidin in non-ID infants in the delayed CC group (suggested reference)... (More)

Background: We aimed to evaluate whether serum hepcidin is a useful indicator of iron status in infants. Methods: Term infants (n = 400) were randomized to delayed (≥180 s) or early (≤10 s) cord clamping (CC). Iron status was assessed at 4 and 12 months. In all cases with iron depletion or iron deficiency (ID) (as defined in “Methods”) (n = 30) and 97 randomly selected iron-replete infants, we analyzed hepcidin and explored its correlation to the intervention, iron status, and perinatal factors. Results: Serum hepcidin concentrations were significantly lower in the early CC group at both time points and in ID infants at 4 months. Median (2.5th–97.5th percentile) hepcidin in non-ID infants in the delayed CC group (suggested reference) was 64.5 (10.9–142.1), 39.5 (3.5–157.7), and 32.9 (11.2–124.2) ng/mL in the cord blood and at 4 and 12 months, respectively. The value of 16 ng/mL was a threshold detecting all cases of iron depletion/ID at 4 months. No similar threshold for ID was observed at 12 months. The strongest predictor of hepcidin at both ages was ferritin. Conclusions: Hepcidin is relevant as iron status indicator in early infancy and may be useful to detect ID. Levels <16 ng/mL at 4 months of age indicates ID. Impact: Serum hepcidin is a relevant indicator of iron status in early infancy.Normal reference in healthy infants is suggested in this study.Serum hepcidin may be useful in clinical practice to detect iron deficiency.

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author
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organization
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type
Contribution to journal
publication status
published
subject
in
Pediatric Research
publisher
International Pediatric Foundation Inc.
external identifiers
  • scopus:85087307303
  • pmid:32610342
ISSN
0031-3998
DOI
10.1038/s41390-020-1045-9
language
English
LU publication?
yes
id
b4407332-1c00-4e5f-9055-d95ffc8105d5
date added to LUP
2020-07-10 13:37:36
date last changed
2024-04-17 11:59:42
@article{b4407332-1c00-4e5f-9055-d95ffc8105d5,
  abstract     = {{<p>Background: We aimed to evaluate whether serum hepcidin is a useful indicator of iron status in infants. Methods: Term infants (n = 400) were randomized to delayed (≥180 s) or early (≤10 s) cord clamping (CC). Iron status was assessed at 4 and 12 months. In all cases with iron depletion or iron deficiency (ID) (as defined in “Methods”) (n = 30) and 97 randomly selected iron-replete infants, we analyzed hepcidin and explored its correlation to the intervention, iron status, and perinatal factors. Results: Serum hepcidin concentrations were significantly lower in the early CC group at both time points and in ID infants at 4 months. Median (2.5th–97.5th percentile) hepcidin in non-ID infants in the delayed CC group (suggested reference) was 64.5 (10.9–142.1), 39.5 (3.5–157.7), and 32.9 (11.2–124.2) ng/mL in the cord blood and at 4 and 12 months, respectively. The value of 16 ng/mL was a threshold detecting all cases of iron depletion/ID at 4 months. No similar threshold for ID was observed at 12 months. The strongest predictor of hepcidin at both ages was ferritin. Conclusions: Hepcidin is relevant as iron status indicator in early infancy and may be useful to detect ID. Levels &lt;16 ng/mL at 4 months of age indicates ID. Impact: Serum hepcidin is a relevant indicator of iron status in early infancy.Normal reference in healthy infants is suggested in this study.Serum hepcidin may be useful in clinical practice to detect iron deficiency.</p>}},
  author       = {{Berglund, Staffan K. and Chmielewska, Anna M. and Domellöf, Magnus and Andersson, Ola}},
  issn         = {{0031-3998}},
  language     = {{eng}},
  month        = {{07}},
  publisher    = {{International Pediatric Foundation Inc.}},
  series       = {{Pediatric Research}},
  title        = {{Hepcidin is a relevant iron status indicator in infancy : results from a randomized trial of early vs. delayed cord clamping}},
  url          = {{http://dx.doi.org/10.1038/s41390-020-1045-9}},
  doi          = {{10.1038/s41390-020-1045-9}},
  year         = {{2020}},
}