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Reduced cerebrospinal fluid level of thyroxine in patients with Alzheimer's disease

Johansson, Per LU ; Almqvist, Erik G. ; Johansson, Jan-Ove ; Mattsson, Niklas ; Hansson, Oskar LU orcid ; Wallin, Anders ; Blennow, Kaj LU ; Zetterberg, Henrik and Svensson, Johan (2013) In Psychoneuroendocrinology 38(7). p.1058-1066
Abstract
Background: Little is known of the association between thyroid hormones in the central nervous system and Alzheimer's disease (AD). We determined thyroid hormone levels in serum and cerebrospinal fluid (CSF) in a well-defined homogeneous mono-center population. Methods: Fifty-nine consecutive patients under primary evaluation for cognitive impairment were recruited. The participants included patients with AD or mild cognitive impairment (MCI) diagnosed with AD upon follow-up (n = 31), patients with stable MCI (SMCI, n = 13), patients with other dementias (n = 15), and healthy controls (n = 19). Thyroid hormones in serum and CSF and AD biomarkers in CSF were analyzed using established immunochemical assays. Cognitive impairment was... (More)
Background: Little is known of the association between thyroid hormones in the central nervous system and Alzheimer's disease (AD). We determined thyroid hormone levels in serum and cerebrospinal fluid (CSF) in a well-defined homogeneous mono-center population. Methods: Fifty-nine consecutive patients under primary evaluation for cognitive impairment were recruited. The participants included patients with AD or mild cognitive impairment (MCI) diagnosed with AD upon follow-up (n = 31), patients with stable MCI (SMCI, n = 13), patients with other dementias (n = 15), and healthy controls (n = 19). Thyroid hormones in serum and CSF and AD biomarkers in CSF were analyzed using established immunochemical assays. Cognitive impairment was estimated using mini-mental state examination (MMSE). Results: Serum levels of free and total thyroxine (T4) and triiodothyronine (T3) were similar in all groups whereas a marginal increase in serum thyroid-stimulating hormone (TSH) level was observed in the AD patients. The CSF level of total T4 was decreased in patients with AD and other dementias compared to SMCI (both P = 0.01) and healthy controls (both P = 0.001), whereas CSF levels of TSH and total T3 were unchanged. In the total study population, CSF total 14 level correlated positively with MMSE score (r = 0.26, P < 0.05) and negatively with CSF total-tau (T-Tau) level (r = -0.23, P < 0.05). Conclusion: Patients with AD as well as other dementias had signs of mild brain hypothyroidism, which could only to a small extent be detected in serum values. (C) 2012 Elsevier Ltd. All rights reserved. (Less)
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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
T4, T3, TSH, Alzheimer's disease, Cerebrospinal fluid
in
Psychoneuroendocrinology
volume
38
issue
7
pages
1058 - 1066
publisher
Elsevier
external identifiers
  • wos:000320412400011
  • scopus:84877926438
  • pmid:23159010
ISSN
1873-3360
DOI
10.1016/j.psyneuen.2012.10.012
project
Endocrine and diagnostic aspects of cognitive impairment
language
English
LU publication?
yes
id
b451ca72-606f-4a97-9855-2eff44090e53 (old id 3980135)
date added to LUP
2016-04-01 10:58:48
date last changed
2022-05-18 03:41:44
@article{b451ca72-606f-4a97-9855-2eff44090e53,
  abstract     = {{Background: Little is known of the association between thyroid hormones in the central nervous system and Alzheimer's disease (AD). We determined thyroid hormone levels in serum and cerebrospinal fluid (CSF) in a well-defined homogeneous mono-center population. Methods: Fifty-nine consecutive patients under primary evaluation for cognitive impairment were recruited. The participants included patients with AD or mild cognitive impairment (MCI) diagnosed with AD upon follow-up (n = 31), patients with stable MCI (SMCI, n = 13), patients with other dementias (n = 15), and healthy controls (n = 19). Thyroid hormones in serum and CSF and AD biomarkers in CSF were analyzed using established immunochemical assays. Cognitive impairment was estimated using mini-mental state examination (MMSE). Results: Serum levels of free and total thyroxine (T4) and triiodothyronine (T3) were similar in all groups whereas a marginal increase in serum thyroid-stimulating hormone (TSH) level was observed in the AD patients. The CSF level of total T4 was decreased in patients with AD and other dementias compared to SMCI (both P = 0.01) and healthy controls (both P = 0.001), whereas CSF levels of TSH and total T3 were unchanged. In the total study population, CSF total 14 level correlated positively with MMSE score (r = 0.26, P &lt; 0.05) and negatively with CSF total-tau (T-Tau) level (r = -0.23, P &lt; 0.05). Conclusion: Patients with AD as well as other dementias had signs of mild brain hypothyroidism, which could only to a small extent be detected in serum values. (C) 2012 Elsevier Ltd. All rights reserved.}},
  author       = {{Johansson, Per and Almqvist, Erik G. and Johansson, Jan-Ove and Mattsson, Niklas and Hansson, Oskar and Wallin, Anders and Blennow, Kaj and Zetterberg, Henrik and Svensson, Johan}},
  issn         = {{1873-3360}},
  keywords     = {{T4; T3; TSH; Alzheimer's disease; Cerebrospinal fluid}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{1058--1066}},
  publisher    = {{Elsevier}},
  series       = {{Psychoneuroendocrinology}},
  title        = {{Reduced cerebrospinal fluid level of thyroxine in patients with Alzheimer's disease}},
  url          = {{http://dx.doi.org/10.1016/j.psyneuen.2012.10.012}},
  doi          = {{10.1016/j.psyneuen.2012.10.012}},
  volume       = {{38}},
  year         = {{2013}},
}