Reduced cerebrospinal fluid level of thyroxine in patients with Alzheimer's disease
(2013) In Psychoneuroendocrinology 38(7). p.1058-1066- Abstract
- Background: Little is known of the association between thyroid hormones in the central nervous system and Alzheimer's disease (AD). We determined thyroid hormone levels in serum and cerebrospinal fluid (CSF) in a well-defined homogeneous mono-center population. Methods: Fifty-nine consecutive patients under primary evaluation for cognitive impairment were recruited. The participants included patients with AD or mild cognitive impairment (MCI) diagnosed with AD upon follow-up (n = 31), patients with stable MCI (SMCI, n = 13), patients with other dementias (n = 15), and healthy controls (n = 19). Thyroid hormones in serum and CSF and AD biomarkers in CSF were analyzed using established immunochemical assays. Cognitive impairment was... (More)
- Background: Little is known of the association between thyroid hormones in the central nervous system and Alzheimer's disease (AD). We determined thyroid hormone levels in serum and cerebrospinal fluid (CSF) in a well-defined homogeneous mono-center population. Methods: Fifty-nine consecutive patients under primary evaluation for cognitive impairment were recruited. The participants included patients with AD or mild cognitive impairment (MCI) diagnosed with AD upon follow-up (n = 31), patients with stable MCI (SMCI, n = 13), patients with other dementias (n = 15), and healthy controls (n = 19). Thyroid hormones in serum and CSF and AD biomarkers in CSF were analyzed using established immunochemical assays. Cognitive impairment was estimated using mini-mental state examination (MMSE). Results: Serum levels of free and total thyroxine (T4) and triiodothyronine (T3) were similar in all groups whereas a marginal increase in serum thyroid-stimulating hormone (TSH) level was observed in the AD patients. The CSF level of total T4 was decreased in patients with AD and other dementias compared to SMCI (both P = 0.01) and healthy controls (both P = 0.001), whereas CSF levels of TSH and total T3 were unchanged. In the total study population, CSF total 14 level correlated positively with MMSE score (r = 0.26, P < 0.05) and negatively with CSF total-tau (T-Tau) level (r = -0.23, P < 0.05). Conclusion: Patients with AD as well as other dementias had signs of mild brain hypothyroidism, which could only to a small extent be detected in serum values. (C) 2012 Elsevier Ltd. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3980135
- author
- Johansson, Per LU ; Almqvist, Erik G. ; Johansson, Jan-Ove ; Mattsson, Niklas ; Hansson, Oskar LU ; Wallin, Anders ; Blennow, Kaj LU ; Zetterberg, Henrik and Svensson, Johan
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- T4, T3, TSH, Alzheimer's disease, Cerebrospinal fluid
- in
- Psychoneuroendocrinology
- volume
- 38
- issue
- 7
- pages
- 1058 - 1066
- publisher
- Elsevier
- external identifiers
-
- wos:000320412400011
- scopus:84877926438
- pmid:23159010
- ISSN
- 1873-3360
- DOI
- 10.1016/j.psyneuen.2012.10.012
- project
- Endocrine and diagnostic aspects of cognitive impairment
- language
- English
- LU publication?
- yes
- id
- b451ca72-606f-4a97-9855-2eff44090e53 (old id 3980135)
- date added to LUP
- 2016-04-01 10:58:48
- date last changed
- 2022-05-18 03:41:44
@article{b451ca72-606f-4a97-9855-2eff44090e53, abstract = {{Background: Little is known of the association between thyroid hormones in the central nervous system and Alzheimer's disease (AD). We determined thyroid hormone levels in serum and cerebrospinal fluid (CSF) in a well-defined homogeneous mono-center population. Methods: Fifty-nine consecutive patients under primary evaluation for cognitive impairment were recruited. The participants included patients with AD or mild cognitive impairment (MCI) diagnosed with AD upon follow-up (n = 31), patients with stable MCI (SMCI, n = 13), patients with other dementias (n = 15), and healthy controls (n = 19). Thyroid hormones in serum and CSF and AD biomarkers in CSF were analyzed using established immunochemical assays. Cognitive impairment was estimated using mini-mental state examination (MMSE). Results: Serum levels of free and total thyroxine (T4) and triiodothyronine (T3) were similar in all groups whereas a marginal increase in serum thyroid-stimulating hormone (TSH) level was observed in the AD patients. The CSF level of total T4 was decreased in patients with AD and other dementias compared to SMCI (both P = 0.01) and healthy controls (both P = 0.001), whereas CSF levels of TSH and total T3 were unchanged. In the total study population, CSF total 14 level correlated positively with MMSE score (r = 0.26, P < 0.05) and negatively with CSF total-tau (T-Tau) level (r = -0.23, P < 0.05). Conclusion: Patients with AD as well as other dementias had signs of mild brain hypothyroidism, which could only to a small extent be detected in serum values. (C) 2012 Elsevier Ltd. All rights reserved.}}, author = {{Johansson, Per and Almqvist, Erik G. and Johansson, Jan-Ove and Mattsson, Niklas and Hansson, Oskar and Wallin, Anders and Blennow, Kaj and Zetterberg, Henrik and Svensson, Johan}}, issn = {{1873-3360}}, keywords = {{T4; T3; TSH; Alzheimer's disease; Cerebrospinal fluid}}, language = {{eng}}, number = {{7}}, pages = {{1058--1066}}, publisher = {{Elsevier}}, series = {{Psychoneuroendocrinology}}, title = {{Reduced cerebrospinal fluid level of thyroxine in patients with Alzheimer's disease}}, url = {{http://dx.doi.org/10.1016/j.psyneuen.2012.10.012}}, doi = {{10.1016/j.psyneuen.2012.10.012}}, volume = {{38}}, year = {{2013}}, }