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Osteocalcin, glucose metabolism, lipid profile and chronic low-grade inflammation in middle-aged and elderly Chinese.

Ling, Chen; Li, Qi; Yang, Z; Ye, Z; Huang, Yuan; He, M; Wen, J; Wang, X; Lu, B and Hu, J, et al. (2013) In Diabetic Medicine 30(3). p.309-317
Abstract
Aim:

To assess the relationship between serum total osteocalcin and measurements of adiposity, glucose tolerance, lipid profile, adipokine and chronic low-grade inflammation in middle-aged and elderly Chinese subjects.



Methods:

We performed a cross-sectional community-based study in central Shanghai. Serum total osteocalcin was measured by radioimmunoassay in 783 men and 946 post-menopausal women. Their associations with measurements of adiposity, glucose tolerance, lipid profile and chronic low-grade inflammation were examined.



Results:

Serum total osteocalcin levels revealed a sexual dimorphism, with post-menopausal women having significantly higher levels than men (P... (More)
Aim:

To assess the relationship between serum total osteocalcin and measurements of adiposity, glucose tolerance, lipid profile, adipokine and chronic low-grade inflammation in middle-aged and elderly Chinese subjects.



Methods:

We performed a cross-sectional community-based study in central Shanghai. Serum total osteocalcin was measured by radioimmunoassay in 783 men and 946 post-menopausal women. Their associations with measurements of adiposity, glucose tolerance, lipid profile and chronic low-grade inflammation were examined.



Results:

Serum total osteocalcin levels revealed a sexual dimorphism, with post-menopausal women having significantly higher levels than men (P < 0.001). Serum osteocalcin levels of participants with self-reported cardiovascular disease were significantly lower (P = 0.044) than those without. In men, serum osteocalcin levels of participants with the metabolic syndrome were significantly lower than those without the metabolic syndrome (P = 0.036). Serum osteocalcin correlated negatively with fasting serum insulin, homeostasis model assessment of insulin resistance, alanine aminotransferase, triglycerides and total cholesterol, and positively with homeostasis model assessment of β-cell function in both men and post-menopausal women (all P < 0.05). In men, serum osteocalcin correlated negatively with BMI, diastolic blood pressure, fasting plasma glucose and 2-h oral glucose tolerance test glucose after adjustment for age (all P < 0.05). In post-menopausal women, serum osteocalcin correlated negatively with waist-hip ratio, LDL cholesterol and C-reactive protein, and positively with adiponectin (all P < 0.05). Serum osteocalcin was not associated with CXC chemokine ligand 5 level (P > 0.05). Alanine aminotransferase was an independent predictor of serum osteocalcin in both men and post-menopausal women (both P < 0.001). Adiponectin was an independent predictor of serum osteocalcin in post-menopausal women (P = 0.011). Serum osteocalcin was an independent predictor of homeostasis model assessment of β-cell function in both genders (both P < 0.05).



Conclusions:

Serum total osteocalcin was closely associated with glucose and lipid metabolism in both Chinese men and post-menopausal women. © 2012 The Authors. Diabetic Medicine © 2012 Diabetes UK. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetic Medicine
volume
30
issue
3
pages
309 - 317
publisher
Wiley-Blackwell
external identifiers
  • wos:000315339300016
  • pmid:22913521
  • scopus:84874185722
ISSN
1464-5491
DOI
10.1111/j.1464-5491.2012.03769.x
language
English
LU publication?
yes
id
b452b4db-4b7e-40ab-99cf-bb00694dfdc0 (old id 3047309)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22913521?dopt=Abstract
date added to LUP
2012-09-05 20:35:38
date last changed
2019-07-07 03:00:12
@article{b452b4db-4b7e-40ab-99cf-bb00694dfdc0,
  abstract     = {Aim: <br/><br>
To assess the relationship between serum total osteocalcin and measurements of adiposity, glucose tolerance, lipid profile, adipokine and chronic low-grade inflammation in middle-aged and elderly Chinese subjects. <br/><br>
<br/><br>
Methods: <br/><br>
We performed a cross-sectional community-based study in central Shanghai. Serum total osteocalcin was measured by radioimmunoassay in 783 men and 946 post-menopausal women. Their associations with measurements of adiposity, glucose tolerance, lipid profile and chronic low-grade inflammation were examined. <br/><br>
<br/><br>
Results: <br/><br>
Serum total osteocalcin levels revealed a sexual dimorphism, with post-menopausal women having significantly higher levels than men (P &lt; 0.001). Serum osteocalcin levels of participants with self-reported cardiovascular disease were significantly lower (P = 0.044) than those without. In men, serum osteocalcin levels of participants with the metabolic syndrome were significantly lower than those without the metabolic syndrome (P = 0.036). Serum osteocalcin correlated negatively with fasting serum insulin, homeostasis model assessment of insulin resistance, alanine aminotransferase, triglycerides and total cholesterol, and positively with homeostasis model assessment of β-cell function in both men and post-menopausal women (all P &lt; 0.05). In men, serum osteocalcin correlated negatively with BMI, diastolic blood pressure, fasting plasma glucose and 2-h oral glucose tolerance test glucose after adjustment for age (all P &lt; 0.05). In post-menopausal women, serum osteocalcin correlated negatively with waist-hip ratio, LDL cholesterol and C-reactive protein, and positively with adiponectin (all P &lt; 0.05). Serum osteocalcin was not associated with CXC chemokine ligand 5 level (P &gt; 0.05). Alanine aminotransferase was an independent predictor of serum osteocalcin in both men and post-menopausal women (both P &lt; 0.001). Adiponectin was an independent predictor of serum osteocalcin in post-menopausal women (P = 0.011). Serum osteocalcin was an independent predictor of homeostasis model assessment of β-cell function in both genders (both P &lt; 0.05). <br/><br>
<br/><br>
Conclusions: <br/><br>
Serum total osteocalcin was closely associated with glucose and lipid metabolism in both Chinese men and post-menopausal women. © 2012 The Authors. Diabetic Medicine © 2012 Diabetes UK.},
  author       = {Ling, Chen and Li, Qi and Yang, Z and Ye, Z and Huang, Yuan and He, M and Wen, J and Wang, X and Lu, B and Hu, J and Liu, Connor and Ling, Charlotte and Qu, S and Hu, R},
  issn         = {1464-5491},
  language     = {eng},
  number       = {3},
  pages        = {309--317},
  publisher    = {Wiley-Blackwell},
  series       = {Diabetic Medicine},
  title        = {Osteocalcin, glucose metabolism, lipid profile and chronic low-grade inflammation in middle-aged and elderly Chinese.},
  url          = {http://dx.doi.org/10.1111/j.1464-5491.2012.03769.x},
  volume       = {30},
  year         = {2013},
}