Prevalence and factors associated with faecal carriage of extended-spectrum β-lactamase-producing Enterobacterales among peripartum women in the community in Cambodia
(2022) In The Journal of antimicrobial chemotherapy 77(10). p.2658-2666- Abstract
BACKGROUND: In Southeast-Asia, where many conditions associated with dissemination of ESBL-producing Enterobacterales (ESBL-E) in the community are met, data from the community are scarce but show high ESBL-E carriage prevalence. Maternal ESBL-E colonization is considered a risk factor for neonatal colonization, which is the first step towards developing neonatal sepsis. Despite this, ESBL-E carriage prevalence and its risk factors during pregnancy or postpartum remain undefined in Southeast-Asia. OBJECTIVES: To estimate the prevalence of ESBL-E faecal colonization among peripartum women in the community of an urban and a rural area in Cambodia, to investigate ESBL-E genomic characteristics and to identify associated risk factors.... (More)
BACKGROUND: In Southeast-Asia, where many conditions associated with dissemination of ESBL-producing Enterobacterales (ESBL-E) in the community are met, data from the community are scarce but show high ESBL-E carriage prevalence. Maternal ESBL-E colonization is considered a risk factor for neonatal colonization, which is the first step towards developing neonatal sepsis. Despite this, ESBL-E carriage prevalence and its risk factors during pregnancy or postpartum remain undefined in Southeast-Asia. OBJECTIVES: To estimate the prevalence of ESBL-E faecal colonization among peripartum women in the community of an urban and a rural area in Cambodia, to investigate ESBL-E genomic characteristics and to identify associated risk factors. METHODS: Epidemiological data and faecal samples from 423 peripartum women were collected in an urban and rural areas in Cambodia (2015-16). Bacterial cultures, antibiotic susceptibility tests and ESBL gene sequencing were performed. Risk factor analysis was conducted using logistic regression. RESULTS: The prevalence of ESBL-E faecal carriage was 79.2% (95% CI 75.0%-82.8%) among which Escherichia coli (n = 315/335, 94.0%) were most frequent. All isolates were multidrug resistant. Among 318 ESBL-E, the genes most frequently detected were blaCTX-M-15 (41.5%), blaCTX-M-55 (24.8%), and blaCTX-M-27 (15.1%). Low income, undernutrition, multiparity, regular consumption of pork, dried meat, and raw vegetables, were associated with ESBL-E faecal carriage. CONCLUSIONS: The high prevalence of ESBL-E carriage observed among peripartum women in Southeast-Asia and the identified associated factors underline the urgent need for public health measures to address antimicrobial resistance, including a 'One Health' approach.
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- author
- author collaboration
- organization
- publishing date
- 2022-09-30
- type
- Contribution to journal
- publication status
- published
- subject
- in
- The Journal of antimicrobial chemotherapy
- volume
- 77
- issue
- 10
- pages
- 9 pages
- publisher
- Oxford University Press
- external identifiers
-
- pmid:35794710
- scopus:85139536082
- ISSN
- 1460-2091
- DOI
- 10.1093/jac/dkac224
- language
- English
- LU publication?
- yes
- id
- b45420d0-e5e3-4a8f-93f5-8cae67ba19f8
- date added to LUP
- 2022-12-09 15:33:26
- date last changed
- 2024-04-04 05:44:46
@article{b45420d0-e5e3-4a8f-93f5-8cae67ba19f8,
abstract = {{<p>BACKGROUND: In Southeast-Asia, where many conditions associated with dissemination of ESBL-producing Enterobacterales (ESBL-E) in the community are met, data from the community are scarce but show high ESBL-E carriage prevalence. Maternal ESBL-E colonization is considered a risk factor for neonatal colonization, which is the first step towards developing neonatal sepsis. Despite this, ESBL-E carriage prevalence and its risk factors during pregnancy or postpartum remain undefined in Southeast-Asia. OBJECTIVES: To estimate the prevalence of ESBL-E faecal colonization among peripartum women in the community of an urban and a rural area in Cambodia, to investigate ESBL-E genomic characteristics and to identify associated risk factors. METHODS: Epidemiological data and faecal samples from 423 peripartum women were collected in an urban and rural areas in Cambodia (2015-16). Bacterial cultures, antibiotic susceptibility tests and ESBL gene sequencing were performed. Risk factor analysis was conducted using logistic regression. RESULTS: The prevalence of ESBL-E faecal carriage was 79.2% (95% CI 75.0%-82.8%) among which Escherichia coli (n = 315/335, 94.0%) were most frequent. All isolates were multidrug resistant. Among 318 ESBL-E, the genes most frequently detected were blaCTX-M-15 (41.5%), blaCTX-M-55 (24.8%), and blaCTX-M-27 (15.1%). Low income, undernutrition, multiparity, regular consumption of pork, dried meat, and raw vegetables, were associated with ESBL-E faecal carriage. CONCLUSIONS: The high prevalence of ESBL-E carriage observed among peripartum women in Southeast-Asia and the identified associated factors underline the urgent need for public health measures to address antimicrobial resistance, including a 'One Health' approach.</p>}},
author = {{de Lauzanne, Agathe and Sreng, Navin and Foucaud, Elsa and Sok, Touch and Chon, Thida and Yem, Chhaily and Hak, Veasna and Heng, Sothada and Soda, Meng and Gouali, Malika and Nadimpalli, Maya and Inghammar, Malin and Rabenandrasana, Mamitina Alain Noah and Collard, Jean Marc and Vray, Muriel and Hello, Simon Le and Kerleguer, Alexandra and Piola, Patrice and Delarocque-Astagneau, Elisabeth and Guillemot, Didier and Huynh, Bich Tram and Borand, Laurence}},
issn = {{1460-2091}},
language = {{eng}},
month = {{09}},
number = {{10}},
pages = {{2658--2666}},
publisher = {{Oxford University Press}},
series = {{The Journal of antimicrobial chemotherapy}},
title = {{Prevalence and factors associated with faecal carriage of extended-spectrum β-lactamase-producing Enterobacterales among peripartum women in the community in Cambodia}},
url = {{http://dx.doi.org/10.1093/jac/dkac224}},
doi = {{10.1093/jac/dkac224}},
volume = {{77}},
year = {{2022}},
}