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Interactions between hormonal contraception and antiepileptic drugs : Clinical and mechanistic considerations

Reimers, Arne LU orcid ; Brodtkorb, Eylert and Sabers, Anne (2015) In Seizure 28. p.66-70
Abstract

Antiepileptic drugs (AEDs) and hormonal contraceptives may affect each other's metabolism and clinical efficacy. Loss of seizure control and unplanned pregnancy may occur when these compounds are used concomitantly. Although a large number of available preparations yield a plethora of possible drug combinations, most of these drug interactions are predictable and, thus, avoidable. Unfortunately, there is a substantial lack of data regarding the newer AEDs. Detailed understanding of these issues is necessary for those who prescribe AEDs and/or hormonal contraception to women with epilepsy, as well as for those who provide comprehensive care, education and counseling to them, in order to reduce the unacceptably high number of unplanned... (More)

Antiepileptic drugs (AEDs) and hormonal contraceptives may affect each other's metabolism and clinical efficacy. Loss of seizure control and unplanned pregnancy may occur when these compounds are used concomitantly. Although a large number of available preparations yield a plethora of possible drug combinations, most of these drug interactions are predictable and, thus, avoidable. Unfortunately, there is a substantial lack of data regarding the newer AEDs. Detailed understanding of these issues is necessary for those who prescribe AEDs and/or hormonal contraception to women with epilepsy, as well as for those who provide comprehensive care, education and counseling to them, in order to reduce the unacceptably high number of unplanned pregnancies among women with epilepsy.

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author
; and
publishing date
type
Contribution to journal
publication status
published
keywords
Antiepileptic drugs, Contraceptives, Drug interactions, Ethinyl estradiol, Hormonal contraception, Progestins
in
Seizure
volume
28
pages
66 - 70
publisher
Elsevier
external identifiers
  • pmid:25843765
  • scopus:84929288518
ISSN
1059-1311
DOI
10.1016/j.seizure.2015.03.006
language
English
LU publication?
no
id
b472f243-33cd-4136-acd3-66ad1ef83e1c
date added to LUP
2024-08-31 14:46:41
date last changed
2025-08-03 21:58:35
@article{b472f243-33cd-4136-acd3-66ad1ef83e1c,
  abstract     = {{<p>Antiepileptic drugs (AEDs) and hormonal contraceptives may affect each other's metabolism and clinical efficacy. Loss of seizure control and unplanned pregnancy may occur when these compounds are used concomitantly. Although a large number of available preparations yield a plethora of possible drug combinations, most of these drug interactions are predictable and, thus, avoidable. Unfortunately, there is a substantial lack of data regarding the newer AEDs. Detailed understanding of these issues is necessary for those who prescribe AEDs and/or hormonal contraception to women with epilepsy, as well as for those who provide comprehensive care, education and counseling to them, in order to reduce the unacceptably high number of unplanned pregnancies among women with epilepsy.</p>}},
  author       = {{Reimers, Arne and Brodtkorb, Eylert and Sabers, Anne}},
  issn         = {{1059-1311}},
  keywords     = {{Antiepileptic drugs; Contraceptives; Drug interactions; Ethinyl estradiol; Hormonal contraception; Progestins}},
  language     = {{eng}},
  month        = {{05}},
  pages        = {{66--70}},
  publisher    = {{Elsevier}},
  series       = {{Seizure}},
  title        = {{Interactions between hormonal contraception and antiepileptic drugs : Clinical and mechanistic considerations}},
  url          = {{http://dx.doi.org/10.1016/j.seizure.2015.03.006}},
  doi          = {{10.1016/j.seizure.2015.03.006}},
  volume       = {{28}},
  year         = {{2015}},
}