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Functional Studies of microRNAs in Neural Stem Cells : Problems and Perspectives

Åkerblom, Malin LU ; Sachdeva, Rohit LU and Jakobsson, Johan LU orcid (2012) In Frontiers in Neuroscience 6.
Abstract

In adult mammals, neural stem cells (NSCs) are found in two niches of the brain; the subventricular zone by the lateral ventricles and the subgranular zone of the dentate gyrus in the hippocampus. Neurogenesis is a complex process that is tightly controlled on a molecular level. Recently, microRNAs (miRNAs) have been implicated to play a central role in the regulation of NCSs. miRNAs are small, endogenously expressed RNAs that regulate gene expression at the post-transcriptional level. However, functional studies of miRNAs are complicated due to current technical limitations. In this review we describe recent findings about miRNAs in NSCs looking closely at miR-124, miR-9, and let-7. In addition, we highlight technical strategies used... (More)

In adult mammals, neural stem cells (NSCs) are found in two niches of the brain; the subventricular zone by the lateral ventricles and the subgranular zone of the dentate gyrus in the hippocampus. Neurogenesis is a complex process that is tightly controlled on a molecular level. Recently, microRNAs (miRNAs) have been implicated to play a central role in the regulation of NCSs. miRNAs are small, endogenously expressed RNAs that regulate gene expression at the post-transcriptional level. However, functional studies of miRNAs are complicated due to current technical limitations. In this review we describe recent findings about miRNAs in NSCs looking closely at miR-124, miR-9, and let-7. In addition, we highlight technical strategies used to investigate miRNA function, accentuating limitations, and potentials.

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publishing date
type
Contribution to journal
publication status
published
subject
in
Frontiers in Neuroscience
volume
6
article number
14
publisher
Frontiers Media S. A.
external identifiers
  • pmid:22347160
  • scopus:84862157083
  • pmid:22347160
ISSN
1662-4548
DOI
10.3389/fnins.2012.00014
language
English
LU publication?
yes
id
b499794b-3acd-477a-b341-ff705684631f (old id 2366701)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22347160?dopt=Abstract
date added to LUP
2016-04-01 14:07:37
date last changed
2022-02-27 00:54:41
@article{b499794b-3acd-477a-b341-ff705684631f,
  abstract     = {{<p>In adult mammals, neural stem cells (NSCs) are found in two niches of the brain; the subventricular zone by the lateral ventricles and the subgranular zone of the dentate gyrus in the hippocampus. Neurogenesis is a complex process that is tightly controlled on a molecular level. Recently, microRNAs (miRNAs) have been implicated to play a central role in the regulation of NCSs. miRNAs are small, endogenously expressed RNAs that regulate gene expression at the post-transcriptional level. However, functional studies of miRNAs are complicated due to current technical limitations. In this review we describe recent findings about miRNAs in NSCs looking closely at miR-124, miR-9, and let-7. In addition, we highlight technical strategies used to investigate miRNA function, accentuating limitations, and potentials.</p>}},
  author       = {{Åkerblom, Malin and Sachdeva, Rohit and Jakobsson, Johan}},
  issn         = {{1662-4548}},
  language     = {{eng}},
  publisher    = {{Frontiers Media S. A.}},
  series       = {{Frontiers in Neuroscience}},
  title        = {{Functional Studies of microRNAs in Neural Stem Cells : Problems and Perspectives}},
  url          = {{https://lup.lub.lu.se/search/files/3799561/2439630.pdf}},
  doi          = {{10.3389/fnins.2012.00014}},
  volume       = {{6}},
  year         = {{2012}},
}