Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Associations of lifestyle factors with amyloid pathology in persons without dementia

Oomens, J.E. ; Wallin, Å.K. LU ; Ossenkoppele, R. LU and Jansen, W.J. (2025) In Journal of Alzheimer's Disease 108(3). p.1043-1059
Abstract
Background: The association between lifestyle factors and Alzheimer's disease (AD) pathophysiology remains incompletely understood. Objective: The aim of this study was to assess the association of alcohol consumption, smoking behavior, sleep quality and physical, cognitive, and social activity with cerebral amyloid pathology. Methods: For this cross-sectional study, we selected participants from the Amyloid Biomarker Study data pooling initiative. We used generalized estimating equations to assess associations of dichotomized lifestyle measures with amyloid pathology. Results: We included 9171 participants with normal cognition (NC) and 2555 participants with mild cognitive impairment (MCI) from the Amyloid Biomarker Study. Of... (More)
Background: The association between lifestyle factors and Alzheimer's disease (AD) pathophysiology remains incompletely understood. Objective: The aim of this study was to assess the association of alcohol consumption, smoking behavior, sleep quality and physical, cognitive, and social activity with cerebral amyloid pathology. Methods: For this cross-sectional study, we selected participants from the Amyloid Biomarker Study data pooling initiative. We used generalized estimating equations to assess associations of dichotomized lifestyle measures with amyloid pathology. Results: We included 9171 participants with normal cognition (NC) and 2555 participants with mild cognitive impairment (MCI) from the Amyloid Biomarker Study. Of participants with NC, 58% were women, 34% were APOE ε4 carrier, and 27% had amyloid pathology. Of participants with MCI, 48% were women, 47% were APOE ε4 carrier, and 57% had amyloid pathology. In NC, cognitively active participants were less likely to have amyloid pathology (OR = 0.77, 95%CI 0.66–0.89, p (Less)
Please use this url to cite or link to this publication:
author
; ; and
author collaboration
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alzheimer's disease, amyloid, amyloid biomarker study, cerebrospinal fluid, lifestyle, positron emission tomography, Aged, Aged, 80 and over, Alcohol Drinking, Amyloid, Apolipoprotein E4, Cognitive Dysfunction, Cross-Sectional Studies, Dementia, Female, Humans, Life Style, Male, Middle Aged, Smoking, alcohol, amyloid protein, apolipoprotein E4, biological marker, aged, alcohol consumption, Article, clinical feature, cognition, controlled study, cross-sectional study, dementia, demographics, Epworth sleepiness scale, female, human, international physical activity questionnaire, major clinical study, male, mild cognitive impairment, neuropathology, physical activity, Pittsburgh Sleep Quality Index, profile of elderly quality of life, Quality of Life Index, sleep disorder, sleep quality, sleep time, smoking, social behavior, cognitive defect, drinking behavior, genetics, metabolism, middle aged, pathology, psychology, very elderly
in
Journal of Alzheimer's Disease
volume
108
issue
3
pages
17 pages
publisher
SAGE Publications
external identifiers
  • scopus:105023169506
ISSN
1387-2877
DOI
10.1177/13872877251379083
language
English
LU publication?
yes
id
b49e64e0-18c7-47d9-adc5-0bbf9f1675b1
date added to LUP
2026-04-01 09:39:42
date last changed
2026-04-01 09:39:42
@article{b49e64e0-18c7-47d9-adc5-0bbf9f1675b1,
  abstract     = {{Background: The association between lifestyle factors and Alzheimer's disease (AD) pathophysiology remains incompletely understood. Objective: The aim of this study was to assess the association of alcohol consumption, smoking behavior, sleep quality and physical, cognitive, and social activity with cerebral amyloid pathology. Methods: For this cross-sectional study, we selected participants from the Amyloid Biomarker Study data pooling initiative. We used generalized estimating equations to assess associations of dichotomized lifestyle measures with amyloid pathology. Results: We included 9171 participants with normal cognition (NC) and 2555 participants with mild cognitive impairment (MCI) from the Amyloid Biomarker Study. Of participants with NC, 58% were women, 34% were APOE ε4 carrier, and 27% had amyloid pathology. Of participants with MCI, 48% were women, 47% were APOE ε4 carrier, and 57% had amyloid pathology. In NC, cognitively active participants were less likely to have amyloid pathology (OR = 0.77, 95%CI 0.66–0.89, p}},
  author       = {{Oomens, J.E. and Wallin, Å.K. and Ossenkoppele, R. and Jansen, W.J.}},
  issn         = {{1387-2877}},
  keywords     = {{Alzheimer's disease; amyloid; amyloid biomarker study; cerebrospinal fluid; lifestyle; positron emission tomography; Aged; Aged, 80 and over; Alcohol Drinking; Amyloid; Apolipoprotein E4; Cognitive Dysfunction; Cross-Sectional Studies; Dementia; Female; Humans; Life Style; Male; Middle Aged; Smoking; alcohol; amyloid protein; apolipoprotein E4; biological marker; aged; alcohol consumption; Article; clinical feature; cognition; controlled study; cross-sectional study; dementia; demographics; Epworth sleepiness scale; female; human; international physical activity questionnaire; major clinical study; male; mild cognitive impairment; neuropathology; physical activity; Pittsburgh Sleep Quality Index; profile of elderly quality of life; Quality of Life Index; sleep disorder; sleep quality; sleep time; smoking; social behavior; cognitive defect; drinking behavior; genetics; metabolism; middle aged; pathology; psychology; very elderly}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{1043--1059}},
  publisher    = {{SAGE Publications}},
  series       = {{Journal of Alzheimer's Disease}},
  title        = {{Associations of lifestyle factors with amyloid pathology in persons without dementia}},
  url          = {{http://dx.doi.org/10.1177/13872877251379083}},
  doi          = {{10.1177/13872877251379083}},
  volume       = {{108}},
  year         = {{2025}},
}