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Empfehlungen der EULAR zur behandlung der gonarthrose. Bericht einer kommission des "Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT)"

Dougados, Maxime; Doherty, Michael; Pendleton, Adrian; Arden, Nigel; Bannwarth, Bernard; Bijlsma, Johannes W J; Cluzeau, Francois; Cooper, Cyrus; Dieppe, Paul A. and Günther, Klaus Peter, et al. (2002) In Zeitschrift für Rheumatologie 61(3). p.229-243
Abstract

Background: Osteoarthritis (OA) is the most common joint disease encountered throughout Europe. A task force for the EULAR standing committee for clinical trials met in 1998 to determine the methodological and logistical approach required for the development of evidence-based guidelines for treatment of knee OA. The guidelines were restricted to cover all currently available therapies for knee OA diagnosed either clinically and/or radiographically affecting any compartment of the knee. Methods: The first stage was the selection of treatment modalities to be considered. The second stage comprised a search of the electronic databases Medline and Embase using a combination of subject headings and key words. All European language... (More)

Background: Osteoarthritis (OA) is the most common joint disease encountered throughout Europe. A task force for the EULAR standing committee for clinical trials met in 1998 to determine the methodological and logistical approach required for the development of evidence-based guidelines for treatment of knee OA. The guidelines were restricted to cover all currently available therapies for knee OA diagnosed either clinically and/or radiographically affecting any compartment of the knee. Methods: The first stage was the selection of treatment modalities to be considered. The second stage comprised a search of the electronic databases Medline and Embase using a combination of subject headings and key words. All European language publications in the form of systematic reviews, meta-analyses, randomized-controlled trials, controlled trials and observational studies were included. During stage three all of the relevant studies were quality scored. The summary statistics for validated outcome measures, when available, were recorded and where practical the numbers needed to treat (NNT) and the effect size (ES) for each therapy was calculated. The fourth stage involved determination of key clinical propositions by expert consensus employing a Delphi approach. The final stage involved ranking of these propositions according to the available evidence. A second set of propositions relating to a future research agenda was determined by expert consensus using a Delphi approach. Results: Over 2400 English language publications and 400 non-English language publications were identified. Seven hundred and forty four studies presented outcome data of the effects of specific treatments on knee OA. Quantitative analysis of treatment effect was possible in only 61 studies. Recommendations for the management of knee OA based on currently available data and expert opinion are presented. Proposals for a future research agenda are highlighted. Conclusions: These are the first clinical guidelines on knee OA to combine an evidence-based approach and a consensus approach across a wide range of treatment modalities. It is apparent that only certain clinical propositions are supported by substantial research-based evidence, while others are not. There is thus an urgent need for future well designed trials to address key clinical questions.

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alternative title
EULAR recommendations for the management of knee osteoarthritis. Report of a task force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT)
publishing date
type
Contribution to journal
publication status
published
keywords
Knee, Osteoarthritis, Treatment
in
Zeitschrift für Rheumatologie
volume
61
issue
3
pages
15 pages
publisher
Dr Dietrichs Steinkopff Verlag
external identifiers
  • scopus:18444407164
ISSN
0340-1855
DOI
10.1007/s00393-002-0403-9
language
German
LU publication?
no
id
b4b32707-a6f5-4e09-a8db-93d88a064681
date added to LUP
2016-05-05 11:27:54
date last changed
2017-01-01 08:25:17
@article{b4b32707-a6f5-4e09-a8db-93d88a064681,
  abstract     = {<p>Background: Osteoarthritis (OA) is the most common joint disease encountered throughout Europe. A task force for the EULAR standing committee for clinical trials met in 1998 to determine the methodological and logistical approach required for the development of evidence-based guidelines for treatment of knee OA. The guidelines were restricted to cover all currently available therapies for knee OA diagnosed either clinically and/or radiographically affecting any compartment of the knee. Methods: The first stage was the selection of treatment modalities to be considered. The second stage comprised a search of the electronic databases Medline and Embase using a combination of subject headings and key words. All European language publications in the form of systematic reviews, meta-analyses, randomized-controlled trials, controlled trials and observational studies were included. During stage three all of the relevant studies were quality scored. The summary statistics for validated outcome measures, when available, were recorded and where practical the numbers needed to treat (NNT) and the effect size (ES) for each therapy was calculated. The fourth stage involved determination of key clinical propositions by expert consensus employing a Delphi approach. The final stage involved ranking of these propositions according to the available evidence. A second set of propositions relating to a future research agenda was determined by expert consensus using a Delphi approach. Results: Over 2400 English language publications and 400 non-English language publications were identified. Seven hundred and forty four studies presented outcome data of the effects of specific treatments on knee OA. Quantitative analysis of treatment effect was possible in only 61 studies. Recommendations for the management of knee OA based on currently available data and expert opinion are presented. Proposals for a future research agenda are highlighted. Conclusions: These are the first clinical guidelines on knee OA to combine an evidence-based approach and a consensus approach across a wide range of treatment modalities. It is apparent that only certain clinical propositions are supported by substantial research-based evidence, while others are not. There is thus an urgent need for future well designed trials to address key clinical questions.</p>},
  author       = {Dougados, Maxime and Doherty, Michael and Pendleton, Adrian and Arden, Nigel and Bannwarth, Bernard and Bijlsma, Johannes W J and Cluzeau, Francois and Cooper, Cyrus and Dieppe, Paul A. and Günther, Klaus Peter and Hauselmann, Hans J. and Herrero-Beaumont, Gabriel and Kaklamanis, Phaedon M. and Leeb, Burkhard and Lequesne, Michel and Lohmander, Stefan and Mazieres, Bernard and Mola, Emilio Martin and Pavelka, Karel and Serni, Umberto and Swoboda, Bernd and Verbruggen, August A. and Weseloh, Gerd and Zimmermann-Gorska, Irena},
  issn         = {0340-1855},
  keyword      = {Knee,Osteoarthritis,Treatment},
  language     = {ger},
  number       = {3},
  pages        = {229--243},
  publisher    = {Dr Dietrichs Steinkopff Verlag},
  series       = {Zeitschrift für Rheumatologie},
  title        = {Empfehlungen der EULAR zur behandlung der gonarthrose. Bericht einer kommission des "Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT)"},
  url          = {http://dx.doi.org/10.1007/s00393-002-0403-9},
  volume       = {61},
  year         = {2002},
}