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Modulation of Calcium Overload and Calpain Activity

Paquet-Durand, François LU ; Ekström, Per LU and Marigo, Valeria (2019) In RSC Drug Discovery Series 2019-January(66). p.48-60
Abstract

Fluxes of calcium ions (Ca2+) in rod photoreceptors are major regulators of steady-state and light-evoked intracellular reactions to stimuli. The homeostasis of Ca2+ is regulated by channels and pumps localized at the plasma membrane and in intracellular organelles. Photoreceptor degeneration is frequently associated with Ca2+ homeostasis disruption and stimulation of Ca2+ activated proteases, such as calpains. These events trigger molecular pathways leading to cell death. In this chapter we discuss Ca2+ channels and pumps as well as calpains as potential targets of new therapies for retinal degeneration.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
RSC Drug Discovery Series
volume
2019-January
issue
66
pages
13 pages
external identifiers
  • scopus:85056592063
ISSN
2041-3203
DOI
10.1039/9781788013666-00048
language
English
LU publication?
yes
id
b50944ec-4e94-4e95-9340-7d91f6619d01
date added to LUP
2018-11-26 12:50:03
date last changed
2019-01-06 14:17:20
@article{b50944ec-4e94-4e95-9340-7d91f6619d01,
  abstract     = {<p>Fluxes of calcium ions (Ca<sup>2+</sup>) in rod photoreceptors are major regulators of steady-state and light-evoked intracellular reactions to stimuli. The homeostasis of Ca<sup>2+</sup> is regulated by channels and pumps localized at the plasma membrane and in intracellular organelles. Photoreceptor degeneration is frequently associated with Ca<sup>2+</sup> homeostasis disruption and stimulation of Ca<sup>2+</sup> activated proteases, such as calpains. These events trigger molecular pathways leading to cell death. In this chapter we discuss Ca<sup>2+</sup> channels and pumps as well as calpains as potential targets of new therapies for retinal degeneration.</p>},
  author       = {Paquet-Durand, François and Ekström, Per and Marigo, Valeria},
  issn         = {2041-3203},
  language     = {eng},
  number       = {66},
  pages        = {48--60},
  series       = {RSC Drug Discovery Series},
  title        = {Modulation of Calcium Overload and Calpain Activity},
  url          = {http://dx.doi.org/10.1039/9781788013666-00048},
  volume       = {2019-January},
  year         = {2019},
}