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Modulation of Calcium Overload and Calpain Activity

Paquet-Durand, François LU ; Ekström, Per LU and Marigo, Valeria (2019) In RSC Drug Discovery Series 2019-January(66). p.48-60
Abstract

Fluxes of calcium ions (Ca2+) in rod photoreceptors are major regulators of steady-state and light-evoked intracellular reactions to stimuli. The homeostasis of Ca2+ is regulated by channels and pumps localized at the plasma membrane and in intracellular organelles. Photoreceptor degeneration is frequently associated with Ca2+ homeostasis disruption and stimulation of Ca2+ activated proteases, such as calpains. These events trigger molecular pathways leading to cell death. In this chapter we discuss Ca2+ channels and pumps as well as calpains as potential targets of new therapies for retinal degeneration.

Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
RSC Drug Discovery Series
volume
2019-January
issue
66
pages
13 pages
publisher
Royal Society of Chemistry
external identifiers
  • scopus:85056592063
ISSN
2041-3203
DOI
10.1039/9781788013666-00048
language
English
LU publication?
yes
id
b50944ec-4e94-4e95-9340-7d91f6619d01
date added to LUP
2018-11-26 12:50:03
date last changed
2025-04-04 14:57:56
@article{b50944ec-4e94-4e95-9340-7d91f6619d01,
  abstract     = {{<p>Fluxes of calcium ions (Ca<sup>2+</sup>) in rod photoreceptors are major regulators of steady-state and light-evoked intracellular reactions to stimuli. The homeostasis of Ca<sup>2+</sup> is regulated by channels and pumps localized at the plasma membrane and in intracellular organelles. Photoreceptor degeneration is frequently associated with Ca<sup>2+</sup> homeostasis disruption and stimulation of Ca<sup>2+</sup> activated proteases, such as calpains. These events trigger molecular pathways leading to cell death. In this chapter we discuss Ca<sup>2+</sup> channels and pumps as well as calpains as potential targets of new therapies for retinal degeneration.</p>}},
  author       = {{Paquet-Durand, François and Ekström, Per and Marigo, Valeria}},
  issn         = {{2041-3203}},
  language     = {{eng}},
  number       = {{66}},
  pages        = {{48--60}},
  publisher    = {{Royal Society of Chemistry}},
  series       = {{RSC Drug Discovery Series}},
  title        = {{Modulation of Calcium Overload and Calpain Activity}},
  url          = {{http://dx.doi.org/10.1039/9781788013666-00048}},
  doi          = {{10.1039/9781788013666-00048}},
  volume       = {{2019-January}},
  year         = {{2019}},
}