The subcellular Sox11 distribution pattern identifies subsets of mantle cell lymphoma : correlation to overall survival
(2008) In British Journal of Haematology 143(2). p.52-248- Abstract
Gene expression analysis demonstrated high expression of the neuronal transcription factor SOX11 in mantle cell lymphoma (MCL). In contrast to follicular lymphoma, small lymphocytic lymphoma and reactive lymphoid tissue, most MCLs tested (48/53 patients) expressed sox11 protein in the nucleus. Therefore nuclear sox11 expression represents a new tumour marker for a subset of MCL. However, 5/53 MCL cases expressed sox11 only in the cytoplasm; these MCL patients had a shorter survival compared to MCL with nuclear sox11 expression. These results suggest sox11 expression as a new diagnostic marker in MCL that could be related to the clinical and biological behaviour of MCL.
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https://lup.lub.lu.se/record/b50def58-10b7-4a72-9e6d-61870de0a45f
- author
- Wang, Xiao LU ; Asplund, A Charlotta ; Porwit, Anna LU ; Flygare, Jenny ; Smith, C I Edvard ; Christensson, Birger and Sander, Birgitta
- publishing date
- 2008-10
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Aged, Aged, 80 and over, Biomarkers, Tumor/analysis, Cell Nucleus/chemistry, Cyclin D1/genetics, Cytoplasm/chemistry, Female, Gene Expression, Gene Expression Regulation, Neoplastic, Humans, Immunohistochemistry, Kaplan-Meier Estimate, Lymphoma, Mantle-Cell/classification, Male, Middle Aged, SOXC Transcription Factors/genetics, Survival Rate
- in
- British Journal of Haematology
- volume
- 143
- issue
- 2
- pages
- 52 - 248
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:52649171336
- pmid:18729857
- ISSN
- 0007-1048
- DOI
- 10.1111/j.1365-2141.2008.07329.x
- language
- English
- LU publication?
- no
- id
- b50def58-10b7-4a72-9e6d-61870de0a45f
- date added to LUP
- 2021-05-07 09:14:16
- date last changed
- 2024-07-27 16:16:16
@article{b50def58-10b7-4a72-9e6d-61870de0a45f, abstract = {{<p>Gene expression analysis demonstrated high expression of the neuronal transcription factor SOX11 in mantle cell lymphoma (MCL). In contrast to follicular lymphoma, small lymphocytic lymphoma and reactive lymphoid tissue, most MCLs tested (48/53 patients) expressed sox11 protein in the nucleus. Therefore nuclear sox11 expression represents a new tumour marker for a subset of MCL. However, 5/53 MCL cases expressed sox11 only in the cytoplasm; these MCL patients had a shorter survival compared to MCL with nuclear sox11 expression. These results suggest sox11 expression as a new diagnostic marker in MCL that could be related to the clinical and biological behaviour of MCL.</p>}}, author = {{Wang, Xiao and Asplund, A Charlotta and Porwit, Anna and Flygare, Jenny and Smith, C I Edvard and Christensson, Birger and Sander, Birgitta}}, issn = {{0007-1048}}, keywords = {{Aged; Aged, 80 and over; Biomarkers, Tumor/analysis; Cell Nucleus/chemistry; Cyclin D1/genetics; Cytoplasm/chemistry; Female; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Lymphoma, Mantle-Cell/classification; Male; Middle Aged; SOXC Transcription Factors/genetics; Survival Rate}}, language = {{eng}}, number = {{2}}, pages = {{52--248}}, publisher = {{Wiley-Blackwell}}, series = {{British Journal of Haematology}}, title = {{The subcellular Sox11 distribution pattern identifies subsets of mantle cell lymphoma : correlation to overall survival}}, url = {{http://dx.doi.org/10.1111/j.1365-2141.2008.07329.x}}, doi = {{10.1111/j.1365-2141.2008.07329.x}}, volume = {{143}}, year = {{2008}}, }