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The subcellular Sox11 distribution pattern identifies subsets of mantle cell lymphoma : correlation to overall survival

Wang, Xiao LU ; Asplund, A Charlotta ; Porwit, Anna LU ; Flygare, Jenny ; Smith, C I Edvard ; Christensson, Birger and Sander, Birgitta (2008) In British Journal of Haematology 143(2). p.52-248
Abstract

Gene expression analysis demonstrated high expression of the neuronal transcription factor SOX11 in mantle cell lymphoma (MCL). In contrast to follicular lymphoma, small lymphocytic lymphoma and reactive lymphoid tissue, most MCLs tested (48/53 patients) expressed sox11 protein in the nucleus. Therefore nuclear sox11 expression represents a new tumour marker for a subset of MCL. However, 5/53 MCL cases expressed sox11 only in the cytoplasm; these MCL patients had a shorter survival compared to MCL with nuclear sox11 expression. These results suggest sox11 expression as a new diagnostic marker in MCL that could be related to the clinical and biological behaviour of MCL.

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author
; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Aged, Aged, 80 and over, Biomarkers, Tumor/analysis, Cell Nucleus/chemistry, Cyclin D1/genetics, Cytoplasm/chemistry, Female, Gene Expression, Gene Expression Regulation, Neoplastic, Humans, Immunohistochemistry, Kaplan-Meier Estimate, Lymphoma, Mantle-Cell/classification, Male, Middle Aged, SOXC Transcription Factors/genetics, Survival Rate
in
British Journal of Haematology
volume
143
issue
2
pages
52 - 248
publisher
Wiley-Blackwell
external identifiers
  • pmid:18729857
  • scopus:52649171336
ISSN
0007-1048
DOI
10.1111/j.1365-2141.2008.07329.x
language
English
LU publication?
no
id
b50def58-10b7-4a72-9e6d-61870de0a45f
date added to LUP
2021-05-07 09:14:16
date last changed
2024-06-01 11:14:01
@article{b50def58-10b7-4a72-9e6d-61870de0a45f,
  abstract     = {{<p>Gene expression analysis demonstrated high expression of the neuronal transcription factor SOX11 in mantle cell lymphoma (MCL). In contrast to follicular lymphoma, small lymphocytic lymphoma and reactive lymphoid tissue, most MCLs tested (48/53 patients) expressed sox11 protein in the nucleus. Therefore nuclear sox11 expression represents a new tumour marker for a subset of MCL. However, 5/53 MCL cases expressed sox11 only in the cytoplasm; these MCL patients had a shorter survival compared to MCL with nuclear sox11 expression. These results suggest sox11 expression as a new diagnostic marker in MCL that could be related to the clinical and biological behaviour of MCL.</p>}},
  author       = {{Wang, Xiao and Asplund, A Charlotta and Porwit, Anna and Flygare, Jenny and Smith, C I Edvard and Christensson, Birger and Sander, Birgitta}},
  issn         = {{0007-1048}},
  keywords     = {{Aged; Aged, 80 and over; Biomarkers, Tumor/analysis; Cell Nucleus/chemistry; Cyclin D1/genetics; Cytoplasm/chemistry; Female; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Lymphoma, Mantle-Cell/classification; Male; Middle Aged; SOXC Transcription Factors/genetics; Survival Rate}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{52--248}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{British Journal of Haematology}},
  title        = {{The subcellular Sox11 distribution pattern identifies subsets of mantle cell lymphoma : correlation to overall survival}},
  url          = {{http://dx.doi.org/10.1111/j.1365-2141.2008.07329.x}},
  doi          = {{10.1111/j.1365-2141.2008.07329.x}},
  volume       = {{143}},
  year         = {{2008}},
}