Association between clinical outcome and microbiological findings in peritonsillar abscess - an observational study
Lindberg, Elin ; Hermansson, Ann LU ; Nygren, David LU
and Gisselsson-Solén, Marie
LU
(2025)
In European Journal of Clinical Microbiology and Infectious Diseases
- Abstract
Background: Previous studies on causative pathogens in peritonsillar abscesses have yielded varying results. However, Group A streptococci (GAS) and Fusobacterium necrophorum have been identified frequently. The aim of this study was to investigate pathogens in peritonsillar abscesses in patients tested for both ß-hemolytic streptococci and F. necrophorum, and to investigate associations between pathogens and clinical outcome. Method: This retrospective observational study included all patients in the Skåne Region, Sweden (population 1.4 million) with a diagnosis of peritonsillar abscess between 2016 and 20, and in whom tests were performed for both ß-hemolytic streptococci (culture) and F. necrophorum (PCR). Exclusion criteria included... (More)
Background: Previous studies on causative pathogens in peritonsillar abscesses have yielded varying results. However, Group A streptococci (GAS) and Fusobacterium necrophorum have been identified frequently. The aim of this study was to investigate pathogens in peritonsillar abscesses in patients tested for both ß-hemolytic streptococci and F. necrophorum, and to investigate associations between pathogens and clinical outcome. Method: This retrospective observational study included all patients in the Skåne Region, Sweden (population 1.4 million) with a diagnosis of peritonsillar abscess between 2016 and 20, and in whom tests were performed for both ß-hemolytic streptococci (culture) and F. necrophorum (PCR). Exclusion criteria included previous (30 days) purulent complication to pharyngotonsillitis or antibiotic therapy. Chart review from 30 days prior to 6 months after the index visit was performed. Logistic regression was performed to evaluate the association between pathogens and complications, with negative microbiological findings set as reference category. Complications were defined as a composite outcome (0/1) of recurrent pharyngotonsillitis/peritonsillar abscess, other pharyngeal abscess or septic complications within 30 days (early), and 1–6 months (late). Results: In a total of 637 patients, F. necrophorum was identified in 210 (33%), GAS in 159 (28%) and GCS/GGS in 40 (6%) patients. F. necrophorum was most common in adolescents and young adults. Only F. necrophorum was associated with the development of either of early (OR 3.8 (2.0-7.1 95%CI)) and late complications (OR 2.5 (95%CI 1.3–4.9). Conclusion: F. necrophorum was the most commonly identified pathogen in peritonsillar abscesses. It was also the only pathogen associated with the development of complications.
(Less)
- author
- Lindberg, Elin
; Hermansson, Ann
LU
; Nygren, David
LU
and Gisselsson-Solén, Marie
LU
- organization
- publishing date
- 2025
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Complications, Fusobacterium necrophorum, Microbiology, Peritonsillar abscess, Streptococcus pyogenes
- in
- European Journal of Clinical Microbiology and Infectious Diseases
- publisher
- Springer
- external identifiers
-
- scopus:105005104035
- pmid:40366504
- ISSN
- 0934-9723
- DOI
- 10.1007/s10096-025-05156-y
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © The Author(s) 2025.
- id
- b5370a15-214a-4e00-a92c-1f6a5b7b4c51
- date added to LUP
- 2025-05-28 12:06:42
- date last changed
- 2025-05-29 03:00:07
@article{b5370a15-214a-4e00-a92c-1f6a5b7b4c51,
abstract = {{<p>Background: Previous studies on causative pathogens in peritonsillar abscesses have yielded varying results. However, Group A streptococci (GAS) and Fusobacterium necrophorum have been identified frequently. The aim of this study was to investigate pathogens in peritonsillar abscesses in patients tested for both ß-hemolytic streptococci and F. necrophorum, and to investigate associations between pathogens and clinical outcome. Method: This retrospective observational study included all patients in the Skåne Region, Sweden (population 1.4 million) with a diagnosis of peritonsillar abscess between 2016 and 20, and in whom tests were performed for both ß-hemolytic streptococci (culture) and F. necrophorum (PCR). Exclusion criteria included previous (30 days) purulent complication to pharyngotonsillitis or antibiotic therapy. Chart review from 30 days prior to 6 months after the index visit was performed. Logistic regression was performed to evaluate the association between pathogens and complications, with negative microbiological findings set as reference category. Complications were defined as a composite outcome (0/1) of recurrent pharyngotonsillitis/peritonsillar abscess, other pharyngeal abscess or septic complications within 30 days (early), and 1–6 months (late). Results: In a total of 637 patients, F. necrophorum was identified in 210 (33%), GAS in 159 (28%) and GCS/GGS in 40 (6%) patients. F. necrophorum was most common in adolescents and young adults. Only F. necrophorum was associated with the development of either of early (OR 3.8 (2.0-7.1 95%CI)) and late complications (OR 2.5 (95%CI 1.3–4.9). Conclusion: F. necrophorum was the most commonly identified pathogen in peritonsillar abscesses. It was also the only pathogen associated with the development of complications.</p>}},
author = {{Lindberg, Elin and Hermansson, Ann and Nygren, David and Gisselsson-Solén, Marie}},
issn = {{0934-9723}},
keywords = {{Complications; Fusobacterium necrophorum; Microbiology; Peritonsillar abscess; Streptococcus pyogenes}},
language = {{eng}},
publisher = {{Springer}},
series = {{European Journal of Clinical Microbiology and Infectious Diseases}},
title = {{Association between clinical outcome and microbiological findings in peritonsillar abscess - an observational study}},
url = {{http://dx.doi.org/10.1007/s10096-025-05156-y}},
doi = {{10.1007/s10096-025-05156-y}},
year = {{2025}},
}