Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Binding patterns and functional properties of human antibodies to AQP4 and MOG on murine optic nerve and retina

Faissner, Simon ; Graz, Florian ; Reinehr, Sabrina ; Petrikowski, Laura ; Haupeltshofer, Steffen LU ; Ceylan, Ulaş ; Stute, Gesa ; Winklmeier, Stephan ; Pache, Florence and Paul, Friedemann , et al. (2020) In Journal of Neuroimmunology 342.
Abstract

Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune-inflammatory CNS disease affecting spinal cord and optic nerves, mediated by autoantibodies against aquaporin-4 (AQP4) and myelin-oligodendrocyte-glycoprotein (MOG). Effects of those immunoglobulins (Ig) on retina and optic nerve are incompletely understood. We investigated AQP4-IgG and MOG-IgG sera on retina and optic nerve ex vivo and in 2D2 mice, which harbor a transgenic MOG-specific T-cell receptor. Some sera reacted with murine retina and optic nerve showing distinct binding patterns, suggesting different epitopes being targeted in both subgroups. Transfer of total IgG from a MOG-IgG positive patient to 2D2 mice did neither enhance disability nor induce functional or... (More)

Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune-inflammatory CNS disease affecting spinal cord and optic nerves, mediated by autoantibodies against aquaporin-4 (AQP4) and myelin-oligodendrocyte-glycoprotein (MOG). Effects of those immunoglobulins (Ig) on retina and optic nerve are incompletely understood. We investigated AQP4-IgG and MOG-IgG sera on retina and optic nerve ex vivo and in 2D2 mice, which harbor a transgenic MOG-specific T-cell receptor. Some sera reacted with murine retina and optic nerve showing distinct binding patterns, suggesting different epitopes being targeted in both subgroups. Transfer of total IgG from a MOG-IgG positive patient to 2D2 mice did neither enhance disability nor induce functional or histological alterations in the retina.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; ; ; ; and (Less)
publishing date
type
Contribution to journal
publication status
published
keywords
Aquaporin-4, Autoimmunity, Myelin-oligodendrocyte-glycoprotein, Neuromyelitis optica spectrum disorder, Optic nerve, Retina
in
Journal of Neuroimmunology
volume
342
article number
577194
publisher
Elsevier
external identifiers
  • pmid:32143071
  • scopus:85080120283
ISSN
0165-5728
DOI
10.1016/j.jneuroim.2020.577194
language
English
LU publication?
no
additional info
Publisher Copyright: © 2020 Elsevier B.V.
id
b5529247-9c55-476e-871e-64658f8b3381
date added to LUP
2026-02-04 16:01:58
date last changed
2026-02-04 16:03:03
@article{b5529247-9c55-476e-871e-64658f8b3381,
  abstract     = {{<p>Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune-inflammatory CNS disease affecting spinal cord and optic nerves, mediated by autoantibodies against aquaporin-4 (AQP4) and myelin-oligodendrocyte-glycoprotein (MOG). Effects of those immunoglobulins (Ig) on retina and optic nerve are incompletely understood. We investigated AQP4-IgG and MOG-IgG sera on retina and optic nerve ex vivo and in 2D2 mice, which harbor a transgenic MOG-specific T-cell receptor. Some sera reacted with murine retina and optic nerve showing distinct binding patterns, suggesting different epitopes being targeted in both subgroups. Transfer of total IgG from a MOG-IgG positive patient to 2D2 mice did neither enhance disability nor induce functional or histological alterations in the retina.</p>}},
  author       = {{Faissner, Simon and Graz, Florian and Reinehr, Sabrina and Petrikowski, Laura and Haupeltshofer, Steffen and Ceylan, Ulaş and Stute, Gesa and Winklmeier, Stephan and Pache, Florence and Paul, Friedemann and Ruprecht, Klemens and Meinl, Edgar and Dick, H. Burkhard and Gold, Ralf and Kleiter, Ingo and Joachim, Stephanie C.}},
  issn         = {{0165-5728}},
  keywords     = {{Aquaporin-4; Autoimmunity; Myelin-oligodendrocyte-glycoprotein; Neuromyelitis optica spectrum disorder; Optic nerve; Retina}},
  language     = {{eng}},
  month        = {{05}},
  publisher    = {{Elsevier}},
  series       = {{Journal of Neuroimmunology}},
  title        = {{Binding patterns and functional properties of human antibodies to AQP4 and MOG on murine optic nerve and retina}},
  url          = {{http://dx.doi.org/10.1016/j.jneuroim.2020.577194}},
  doi          = {{10.1016/j.jneuroim.2020.577194}},
  volume       = {{342}},
  year         = {{2020}},
}