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A toxicological and dermatological assessment of alkyl cyclic ketones when used as fragrance ingredients The RIFM Expert Panel

Belsito, D. ; Bickers, D. ; Bruze, Magnus LU ; Calow, P. ; Dagli, M. L. ; Fryer, A. D. ; Greim, H. ; Miyachi, Y. ; Saurat, J. H. and Sipes, I. G. (2013) In Food and Chemical Toxicology 62. p.1-44
Abstract
The alkyl cyclic ketone (ACK) fragrance ingredients are a diverse group of structures with Similar metabolic and toxicity profiles. ACK fragrance materials demonstrate low acute toxicity. Upon repeat dose testing, some adverse effects in biochemical and hematological parameters, and slightly increased liver and kidney weights were reported, primarily at high doses, resulting from adaptive effects. Developmental effects occurred only in the presence of maternal toxicity. Assays in bacteria and mammalian cell systems and the mouse micronucleus assay did not demonstrate genotoxicity. ACK fragrance ingredients are considered non-irritating to the skin of humans; results showed few reactions, most of which were equivocal or involved doses... (More)
The alkyl cyclic ketone (ACK) fragrance ingredients are a diverse group of structures with Similar metabolic and toxicity profiles. ACK fragrance materials demonstrate low acute toxicity. Upon repeat dose testing, some adverse effects in biochemical and hematological parameters, and slightly increased liver and kidney weights were reported, primarily at high doses, resulting from adaptive effects. Developmental effects occurred only in the presence of maternal toxicity. Assays in bacteria and mammalian cell systems and the mouse micronucleus assay did not demonstrate genotoxicity. ACK fragrance ingredients are considered non-irritating to the skin of humans; results showed few reactions, most of which were equivocal or involved doses greater than those in consumer products. Mild to moderate eye irritation in animal tests was observed with most compounds; however, full recovery was usually observed. Human sensitization studies indicate that ACK fragrance ingredients have a low sensitization potential. Diagnostic patch-tests indicated low sensitizing potential in humans; except for fragrance materials which caused reactions at 1% or 5%. Phototoxicity and photosensitization were not demonstrated in humans, and, with the possible exception of acetyl cedrene, would not be expected. It is concluded that ACK materials do not present a safety concern at current levels of use as fragrance ingredients. (C) 2013 Elsevier Ltd. All rights reserved. (Less)
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Contribution to journal
publication status
published
subject
keywords
Group summary, Alkyl cyclic ketone, Toxicology, Dermatology, Assessment
in
Food and Chemical Toxicology
volume
62
pages
1 - 44
publisher
Elsevier
external identifiers
  • wos:000329016800001
  • scopus:84888062744
  • pmid:24246175
ISSN
0278-6915
DOI
10.1016/j.fct.2013.09.033
language
English
LU publication?
yes
id
b56e5194-f8a2-41c2-9e2b-c799ba15083a (old id 4258955)
date added to LUP
2016-04-01 14:44:07
date last changed
2020-03-24 04:09:50
@article{b56e5194-f8a2-41c2-9e2b-c799ba15083a,
  abstract     = {The alkyl cyclic ketone (ACK) fragrance ingredients are a diverse group of structures with Similar metabolic and toxicity profiles. ACK fragrance materials demonstrate low acute toxicity. Upon repeat dose testing, some adverse effects in biochemical and hematological parameters, and slightly increased liver and kidney weights were reported, primarily at high doses, resulting from adaptive effects. Developmental effects occurred only in the presence of maternal toxicity. Assays in bacteria and mammalian cell systems and the mouse micronucleus assay did not demonstrate genotoxicity. ACK fragrance ingredients are considered non-irritating to the skin of humans; results showed few reactions, most of which were equivocal or involved doses greater than those in consumer products. Mild to moderate eye irritation in animal tests was observed with most compounds; however, full recovery was usually observed. Human sensitization studies indicate that ACK fragrance ingredients have a low sensitization potential. Diagnostic patch-tests indicated low sensitizing potential in humans; except for fragrance materials which caused reactions at 1% or 5%. Phototoxicity and photosensitization were not demonstrated in humans, and, with the possible exception of acetyl cedrene, would not be expected. It is concluded that ACK materials do not present a safety concern at current levels of use as fragrance ingredients. (C) 2013 Elsevier Ltd. All rights reserved.},
  author       = {Belsito, D. and Bickers, D. and Bruze, Magnus and Calow, P. and Dagli, M. L. and Fryer, A. D. and Greim, H. and Miyachi, Y. and Saurat, J. H. and Sipes, I. G.},
  issn         = {0278-6915},
  language     = {eng},
  pages        = {1--44},
  publisher    = {Elsevier},
  series       = {Food and Chemical Toxicology},
  title        = {A toxicological and dermatological assessment of alkyl cyclic ketones when used as fragrance ingredients The RIFM Expert Panel},
  url          = {http://dx.doi.org/10.1016/j.fct.2013.09.033},
  doi          = {10.1016/j.fct.2013.09.033},
  volume       = {62},
  year         = {2013},
}