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Diversity and functions of intestinal mononuclear phagocytes

Joeris, T. LU ; Müller-Luda, K. LU ; Agace, W. W. LU and Mowat, A. Mc I. (2017) In Mucosal Immunology 10(4). p.845-864
Abstract

The intestinal lamina propria (LP) contains a diverse array of mononuclear phagocyte (MNP) subsets, including conventional dendritic cells (cDC), monocytes and tissue-resident macrophages (mÏ †) that collectively play an essential role in mucosal homeostasis, infection and inflammation. In the current review we discuss the function of intestinal cDC and monocyte-derived MNP, highlighting how these subsets play several non-redundant roles in the regulation of intestinal immune responses. While much remains to be learnt, recent findings also underline how the various populations of MNP adapt to deal with the challenges specific to their environment. Understanding these processes should help target individual subsets for â €fine tuning'... (More)

The intestinal lamina propria (LP) contains a diverse array of mononuclear phagocyte (MNP) subsets, including conventional dendritic cells (cDC), monocytes and tissue-resident macrophages (mÏ †) that collectively play an essential role in mucosal homeostasis, infection and inflammation. In the current review we discuss the function of intestinal cDC and monocyte-derived MNP, highlighting how these subsets play several non-redundant roles in the regulation of intestinal immune responses. While much remains to be learnt, recent findings also underline how the various populations of MNP adapt to deal with the challenges specific to their environment. Understanding these processes should help target individual subsets for â €fine tuning' immunological responses within the intestine, a process that may be of relevance both for the treatment of inflammatory bowel disease (IBD) and for optimized vaccine design.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Mucosal Immunology
volume
10
issue
4
pages
20 pages
publisher
Nature Publishing Group
external identifiers
  • scopus:85020920341
  • wos:000403479300002
ISSN
1933-0219
DOI
10.1038/mi.2017.22
language
English
LU publication?
yes
id
b59cb454-542e-4b20-a2d1-0e55ae2c6a2c
date added to LUP
2017-07-26 06:57:55
date last changed
2017-09-18 11:39:28
@article{b59cb454-542e-4b20-a2d1-0e55ae2c6a2c,
  abstract     = {<p>The intestinal lamina propria (LP) contains a diverse array of mononuclear phagocyte (MNP) subsets, including conventional dendritic cells (cDC), monocytes and tissue-resident macrophages (mÏ †) that collectively play an essential role in mucosal homeostasis, infection and inflammation. In the current review we discuss the function of intestinal cDC and monocyte-derived MNP, highlighting how these subsets play several non-redundant roles in the regulation of intestinal immune responses. While much remains to be learnt, recent findings also underline how the various populations of MNP adapt to deal with the challenges specific to their environment. Understanding these processes should help target individual subsets for â €fine tuning' immunological responses within the intestine, a process that may be of relevance both for the treatment of inflammatory bowel disease (IBD) and for optimized vaccine design.</p>},
  author       = {Joeris, T. and Müller-Luda, K. and Agace, W. W. and Mowat, A. Mc I.},
  issn         = {1933-0219},
  language     = {eng},
  month        = {07},
  number       = {4},
  pages        = {845--864},
  publisher    = {Nature Publishing Group},
  series       = {Mucosal Immunology},
  title        = {Diversity and functions of intestinal mononuclear phagocytes},
  url          = {http://dx.doi.org/10.1038/mi.2017.22},
  volume       = {10},
  year         = {2017},
}