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Risk of estrogen receptor-specific breast cancer by family history of estrogen receptor subtypes and other cancers

Wang, Qiao-Li LU orcid ; Zhang, Yuqi ; Zeng, Erwei ; Grassmann, Felix ; He, Wei and Czene, Kamila (2023) In Journal of the National Cancer Institute 115(9). p.1020-1028
Abstract

BACKGROUND: The extent to which the risk of estrogen receptor (ER)-specific breast cancer is associated with ER status of breast cancer and other cancers among first-degree relatives is unclear.

METHODS: This population-based cohort included 464 707 cancer-free women in Stockholm, Sweden, during 1978-2019. For ER-negative and ER-positive breast cancers, we estimated hazard ratios (HRs) associated with ER status of female first-degree relatives with breast cancer and of other cancers in all first-degree relatives. Associations between ER-negative and ER-positive status by family cancer history were estimated using logistic regression in a case-only design.

RESULTS: Women with familial ER-positive breast cancer had 1.87 times... (More)

BACKGROUND: The extent to which the risk of estrogen receptor (ER)-specific breast cancer is associated with ER status of breast cancer and other cancers among first-degree relatives is unclear.

METHODS: This population-based cohort included 464 707 cancer-free women in Stockholm, Sweden, during 1978-2019. For ER-negative and ER-positive breast cancers, we estimated hazard ratios (HRs) associated with ER status of female first-degree relatives with breast cancer and of other cancers in all first-degree relatives. Associations between ER-negative and ER-positive status by family cancer history were estimated using logistic regression in a case-only design.

RESULTS: Women with familial ER-positive breast cancer had 1.87 times (95% confidence interval [CI] = 1.77 to 1.97) higher risk of ER-positive subtype, whereas the corresponding hazard ratio for ER-negative was 2.54 (95% CI = 2.08 to 3.10) when having familial ER-negative breast cancer. The risk increased with an increasing number of female first-degree relatives having concordant subtypes and younger age at diagnosis (Ptrend <.001 for both). Nonbreast cancers among first-degree relatives were associated with both ER-positive (HR = 1.14, 95% CI = 1.10 to 1.17) and ER-negative (HR = 1.08, 95% CI = 1.01 to 1.16) breast cancers. Compared with women with ER-positive breast cancer, women with ER-negative breast cancer were more likely to have family history of liver (odds ratio [OR] = 1.33, 95% CI = 1.05 to 1.67), ovary (OR = 1.28, 95% CI = 1.01 to 1.61), and testicle cancer (OR = 1.79, 95% CI = 1.01 to 3.16) but less likely to have family history of endometrial cancer (OR = 0.77, 95% CI = 0.60 to 1.00) and leukemia (OR = 0.72, 95% CI = 0.56 to 0.91).

CONCLUSIONS: Risk of ER-specific breast cancer differs according to ER status of female first-degree relatives with breast cancer and some other cancers of first-degree relatives. This family history information should be considered in the individual risk prediction for ER subtypes.

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author
; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
keywords
Female, Humans, Breast Neoplasms/epidemiology, Receptors, Estrogen, Risk Factors, Logistic Models, Proportional Hazards Models, Receptors, Progesterone
in
Journal of the National Cancer Institute
volume
115
issue
9
pages
1020 - 1028
publisher
Oxford University Press
external identifiers
  • pmid:37243749
  • scopus:85201596387
ISSN
1460-2105
DOI
10.1093/jnci/djad104
language
English
LU publication?
no
additional info
© The Author(s) 2023. Published by Oxford University Press.
id
b5f608f7-a395-44fc-882a-fe7bf741f2ea
date added to LUP
2025-05-12 17:08:35
date last changed
2025-07-08 09:52:46
@article{b5f608f7-a395-44fc-882a-fe7bf741f2ea,
  abstract     = {{<p>BACKGROUND: The extent to which the risk of estrogen receptor (ER)-specific breast cancer is associated with ER status of breast cancer and other cancers among first-degree relatives is unclear.</p><p>METHODS: This population-based cohort included 464 707 cancer-free women in Stockholm, Sweden, during 1978-2019. For ER-negative and ER-positive breast cancers, we estimated hazard ratios (HRs) associated with ER status of female first-degree relatives with breast cancer and of other cancers in all first-degree relatives. Associations between ER-negative and ER-positive status by family cancer history were estimated using logistic regression in a case-only design.</p><p>RESULTS: Women with familial ER-positive breast cancer had 1.87 times (95% confidence interval [CI] = 1.77 to 1.97) higher risk of ER-positive subtype, whereas the corresponding hazard ratio for ER-negative was 2.54 (95% CI = 2.08 to 3.10) when having familial ER-negative breast cancer. The risk increased with an increasing number of female first-degree relatives having concordant subtypes and younger age at diagnosis (Ptrend &lt;.001 for both). Nonbreast cancers among first-degree relatives were associated with both ER-positive (HR = 1.14, 95% CI = 1.10 to 1.17) and ER-negative (HR = 1.08, 95% CI = 1.01 to 1.16) breast cancers. Compared with women with ER-positive breast cancer, women with ER-negative breast cancer were more likely to have family history of liver (odds ratio [OR] = 1.33, 95% CI = 1.05 to 1.67), ovary (OR = 1.28, 95% CI = 1.01 to 1.61), and testicle cancer (OR = 1.79, 95% CI = 1.01 to 3.16) but less likely to have family history of endometrial cancer (OR = 0.77, 95% CI = 0.60 to 1.00) and leukemia (OR = 0.72, 95% CI = 0.56 to 0.91).</p><p>CONCLUSIONS: Risk of ER-specific breast cancer differs according to ER status of female first-degree relatives with breast cancer and some other cancers of first-degree relatives. This family history information should be considered in the individual risk prediction for ER subtypes.</p>}},
  author       = {{Wang, Qiao-Li and Zhang, Yuqi and Zeng, Erwei and Grassmann, Felix and He, Wei and Czene, Kamila}},
  issn         = {{1460-2105}},
  keywords     = {{Female; Humans; Breast Neoplasms/epidemiology; Receptors, Estrogen; Risk Factors; Logistic Models; Proportional Hazards Models; Receptors, Progesterone}},
  language     = {{eng}},
  month        = {{09}},
  number       = {{9}},
  pages        = {{1020--1028}},
  publisher    = {{Oxford University Press}},
  series       = {{Journal of the National Cancer Institute}},
  title        = {{Risk of estrogen receptor-specific breast cancer by family history of estrogen receptor subtypes and other cancers}},
  url          = {{http://dx.doi.org/10.1093/jnci/djad104}},
  doi          = {{10.1093/jnci/djad104}},
  volume       = {{115}},
  year         = {{2023}},
}