Know your enemy or find your friend?—Induction of IgA at mucosal surfaces
Bemark, Mats LU
and Angeletti, Davide
(2021)
In Immunological Reviews
303(1).
p.83-102
- Abstract
Most antibodies produced in the body are of the IgA class. The dominant cell population producing them are plasma cells within the lamina propria of the gastrointestinal tract, but many IgA-producing cells are also found in the airways, within mammary tissues, the urogenital tract and inside the bone marrow. Most IgA antibodies are transported into the lumen by epithelial cells as part of the mucosal secretions, but they are also present in serum and other body fluids. A large part of the commensal microbiota in the gut is covered with IgA antibodies, and it has been demonstrated that this plays a role in maintaining a healthy balance between the host and the bacteria. However, IgA antibodies also play important roles in neutralizing... (More)
Most antibodies produced in the body are of the IgA class. The dominant cell population producing them are plasma cells within the lamina propria of the gastrointestinal tract, but many IgA-producing cells are also found in the airways, within mammary tissues, the urogenital tract and inside the bone marrow. Most IgA antibodies are transported into the lumen by epithelial cells as part of the mucosal secretions, but they are also present in serum and other body fluids. A large part of the commensal microbiota in the gut is covered with IgA antibodies, and it has been demonstrated that this plays a role in maintaining a healthy balance between the host and the bacteria. However, IgA antibodies also play important roles in neutralizing pathogens in the gastrointestinal tract and the upper airways. The distinction between the two roles of IgA - protective and balance-maintaining - not only has implications on function but also on how the production is regulated. Here, we discuss these issues with a special focus on gut and airways.
(Less)
- author
- Bemark, Mats
LU
and Angeletti, Davide
- publishing date
- 2021-09
- type
- Contribution to journal
- publication status
- published
- keywords
- commensal microbiota, IgA, infection, mucosa
- in
- Immunological Reviews
- volume
- 303
- issue
- 1
- pages
- 83 - 102
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85111930078
- pmid:34331314
- ISSN
- 0105-2896
- DOI
- 10.1111/imr.13014
- language
- English
- LU publication?
- no
- additional info
- Publisher Copyright: © 2021 The Authors. Immunological Reviews published by John Wiley & Sons Ltd.
- id
- b5f65a4a-31fb-4a26-8ab0-7724cd5d07fb
- date added to LUP
- 2023-12-06 16:48:24
- date last changed
- 2024-06-15 19:16:13
@article{b5f65a4a-31fb-4a26-8ab0-7724cd5d07fb,
abstract = {{<p>Most antibodies produced in the body are of the IgA class. The dominant cell population producing them are plasma cells within the lamina propria of the gastrointestinal tract, but many IgA-producing cells are also found in the airways, within mammary tissues, the urogenital tract and inside the bone marrow. Most IgA antibodies are transported into the lumen by epithelial cells as part of the mucosal secretions, but they are also present in serum and other body fluids. A large part of the commensal microbiota in the gut is covered with IgA antibodies, and it has been demonstrated that this plays a role in maintaining a healthy balance between the host and the bacteria. However, IgA antibodies also play important roles in neutralizing pathogens in the gastrointestinal tract and the upper airways. The distinction between the two roles of IgA - protective and balance-maintaining - not only has implications on function but also on how the production is regulated. Here, we discuss these issues with a special focus on gut and airways.</p>}},
author = {{Bemark, Mats and Angeletti, Davide}},
issn = {{0105-2896}},
keywords = {{commensal microbiota; IgA; infection; mucosa}},
language = {{eng}},
number = {{1}},
pages = {{83--102}},
publisher = {{Wiley-Blackwell}},
series = {{Immunological Reviews}},
title = {{Know your enemy or find your friend?—Induction of IgA at mucosal surfaces}},
url = {{http://dx.doi.org/10.1111/imr.13014}},
doi = {{10.1111/imr.13014}},
volume = {{303}},
year = {{2021}},
}