Inhibitory effects of recombinant human cystatin C on human coronaviruses
Collins, Arlene R. LU and Grubb, Anders LU
(1991)
In Antimicrobial Agents and Chemotherapy
35(11).
p.2444-2446
- Abstract
Cystatin C, a potent inhibitor of cysteine proteases such as papain and cathepsin B, was examined for its effect on human coronaviruses OC43 and 229e. Both viruses were greater than 99% inhibited by 0.1 mM inhibitor. Endpoint titrations showed that inhibiting activity paralleled that of leupeptin, a serine and cysteine protease inhibitor, and indicated that 1 to 2 microM inhibitor, slightly above physiologic levels, was effective.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/b606154c-215c-4cc2-9c6b-c8be426b916a
- author
- Collins, Arlene R.
LU
and Grubb, Anders
LU
- publishing date
- 1991
- type
- Contribution to journal
- publication status
- published
- keywords
- Antiviral Agents/pharmacology, Cathepsin B/pharmacology, Cells, Cultured, Coronaviridae/drug effects, Cycloheximide/pharmacology, Cystatin C, Cystatins/pharmacology, Escherichia coli/metabolism, Humans, Leupeptins/pharmacology, Papain/pharmacology, Recombinant Proteins/pharmacology, Virus Replication/drug effects
- in
- Antimicrobial Agents and Chemotherapy
- volume
- 35
- issue
- 11
- pages
- 2444 - 2446
- publisher
- American Society for Microbiology
- external identifiers
-
- pmid:1804023
- scopus:0026063144
- ISSN
- 0066-4804
- DOI
- 10.1128/AAC.35.11.2444
- language
- English
- LU publication?
- no
- id
- b606154c-215c-4cc2-9c6b-c8be426b916a
- date added to LUP
- 2021-10-27 14:15:25
- date last changed
- 2024-04-20 16:13:29
@article{b606154c-215c-4cc2-9c6b-c8be426b916a,
abstract = {{<p>Cystatin C, a potent inhibitor of cysteine proteases such as papain and cathepsin B, was examined for its effect on human coronaviruses OC43 and 229e. Both viruses were greater than 99% inhibited by 0.1 mM inhibitor. Endpoint titrations showed that inhibiting activity paralleled that of leupeptin, a serine and cysteine protease inhibitor, and indicated that 1 to 2 microM inhibitor, slightly above physiologic levels, was effective.</p>}},
author = {{Collins, Arlene R. and Grubb, Anders}},
issn = {{0066-4804}},
keywords = {{Antiviral Agents/pharmacology; Cathepsin B/pharmacology; Cells, Cultured; Coronaviridae/drug effects; Cycloheximide/pharmacology; Cystatin C; Cystatins/pharmacology; Escherichia coli/metabolism; Humans; Leupeptins/pharmacology; Papain/pharmacology; Recombinant Proteins/pharmacology; Virus Replication/drug effects}},
language = {{eng}},
number = {{11}},
pages = {{2444--2446}},
publisher = {{American Society for Microbiology}},
series = {{Antimicrobial Agents and Chemotherapy}},
title = {{Inhibitory effects of recombinant human cystatin C on human coronaviruses}},
url = {{http://dx.doi.org/10.1128/AAC.35.11.2444}},
doi = {{10.1128/AAC.35.11.2444}},
volume = {{35}},
year = {{1991}},
}