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Autism spectrum disorders and underlying brain pathology in CHARGE association

Johansson, Maria ; Råstam, Maria LU orcid ; Billstedt, Eva ; Danielsson, Susanna ; Strömland, Kerstin ; Miller, Marilyn and Gillberg, Christopher (2006) In Developmental Medicine & Child Neurology 48(1). p.40-50
Abstract
The rate of autism spectrum disorders (ASDs) and brain abnormalities was analyzed in 31 individuals (15 males, 16 females; age range 1mo to 31y, mean age 8y 11mo) with CHARGE association, as part of a multidisciplinary study. A meticulous neuropsychiatric examination was performed, including standardized autism diagnostic interviews. Judgement regarding ASDs was impossible in three infants and three patients who were deaf and blind. Five individuals met diagnostic criteria for autism, five for an autistic-like condition, and seven for autistic traits. Brain abnormalities were indicated in almost three-quarters of examined individuals, and midline abnormalities of the forebrain in one-third. Awareness of the coexistence of CHARGE and ASDs... (More)
The rate of autism spectrum disorders (ASDs) and brain abnormalities was analyzed in 31 individuals (15 males, 16 females; age range 1mo to 31y, mean age 8y 11mo) with CHARGE association, as part of a multidisciplinary study. A meticulous neuropsychiatric examination was performed, including standardized autism diagnostic interviews. Judgement regarding ASDs was impossible in three infants and three patients who were deaf and blind. Five individuals met diagnostic criteria for autism, five for an autistic-like condition, and seven for autistic traits. Brain abnormalities were indicated in almost three-quarters of examined individuals, and midline abnormalities of the forebrain in one-third. Awareness of the coexistence of CHARGE and ASDs is important in habilitation care in CHARGE. Moreover, the results indicate that a subgroup of ASDs may be associated with errors in early embryonic brain development. (Less)
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; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
* Abnormalities, Multiple/pathology** Adolescent* Adult* Autistic Disorder/classification** Autistic Disorder/pathology** Autonomic Nervous System Diseases/pathology* Brain/abnormalities** Brain/pathology** Child* Child Behavior Disorders/pathology* Child, Preschool* Cognition* Coloboma/pathology* Craniofacial Abnormalities/pathology* Female* Hearing Loss/pathology* Heart Defects, Congenital/pathology* Humans* Infant* Infant, Newborn* Magnetic Resonance Imaging* Male* Neuropsychological Tests* Pregnancy* Pregnancy Complications/pathology* Tomography, X-Ray Computed
in
Developmental Medicine & Child Neurology
volume
48
issue
1
pages
40 - 50
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:31144437077
ISSN
0012-1622
DOI
10.1017/S0012162206000090
language
English
LU publication?
no
id
b62f7bca-9416-4fbe-abd3-04341fb3e606 (old id 1444709)
date added to LUP
2016-04-01 12:13:43
date last changed
2022-02-18 19:38:51
@article{b62f7bca-9416-4fbe-abd3-04341fb3e606,
  abstract     = {{The rate of autism spectrum disorders (ASDs) and brain abnormalities was analyzed in 31 individuals (15 males, 16 females; age range 1mo to 31y, mean age 8y 11mo) with CHARGE association, as part of a multidisciplinary study. A meticulous neuropsychiatric examination was performed, including standardized autism diagnostic interviews. Judgement regarding ASDs was impossible in three infants and three patients who were deaf and blind. Five individuals met diagnostic criteria for autism, five for an autistic-like condition, and seven for autistic traits. Brain abnormalities were indicated in almost three-quarters of examined individuals, and midline abnormalities of the forebrain in one-third. Awareness of the coexistence of CHARGE and ASDs is important in habilitation care in CHARGE. Moreover, the results indicate that a subgroup of ASDs may be associated with errors in early embryonic brain development.}},
  author       = {{Johansson, Maria and Råstam, Maria and Billstedt, Eva and Danielsson, Susanna and Strömland, Kerstin and Miller, Marilyn and Gillberg, Christopher}},
  issn         = {{0012-1622}},
  keywords     = {{* Abnormalities; Multiple/pathology** Adolescent* Adult* Autistic Disorder/classification** Autistic Disorder/pathology** Autonomic Nervous System Diseases/pathology* Brain/abnormalities** Brain/pathology** Child* Child Behavior Disorders/pathology* Child; Preschool* Cognition* Coloboma/pathology* Craniofacial Abnormalities/pathology* Female* Hearing Loss/pathology* Heart Defects; Congenital/pathology* Humans* Infant* Infant; Newborn* Magnetic Resonance Imaging* Male* Neuropsychological Tests* Pregnancy* Pregnancy Complications/pathology* Tomography; X-Ray Computed}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{40--50}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Developmental Medicine & Child Neurology}},
  title        = {{Autism spectrum disorders and underlying brain pathology in CHARGE association}},
  url          = {{http://dx.doi.org/10.1017/S0012162206000090}},
  doi          = {{10.1017/S0012162206000090}},
  volume       = {{48}},
  year         = {{2006}},
}