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Proteins linked to atherosclerosis and cell proliferation are associated with the shrunken pore syndrome in heart failure patients

Xhakollari, Liana LU ; Jujic, Amra LU ; Molvin, John LU ; Nilsson, Peter LU ; Holm, Hannes LU ; Bachus, Erasmus LU ; Leosdottir, Margret LU ; Grubb, Anders LU orcid ; Christensson, Anders LU and Magnusson, Martin LU orcid (2021) In Proteomics Clinical Applications 15(4).
Abstract

PURPOSE: The "Shrunken pore syndrome" (SPS) is characterized by a difference in renal filtration between cystatin C and creatinine, resulting in a low eGFRcystatinC /eGFRcreatinine -ratio. Studies have demonstrated a high risk for cardiovascular morbidity and mortality for patients with SPS. In this discovery study, we explored associations between SPS and proteins implicated in cardiovascular disease and inflammation in patients with heart failure.

EXPERIMENTAL DESIGN: Plasma samples from 300 individuals in HARVEST-Malmö trial hospitalized for the diagnosis of heart failure (mean age 74.9±11.5 years; 30.0% female), were analyzed with a proximity extension assay consisting of 92 proteins. A Bonferroni-corrected p-value of 0.05/92... (More)

PURPOSE: The "Shrunken pore syndrome" (SPS) is characterized by a difference in renal filtration between cystatin C and creatinine, resulting in a low eGFRcystatinC /eGFRcreatinine -ratio. Studies have demonstrated a high risk for cardiovascular morbidity and mortality for patients with SPS. In this discovery study, we explored associations between SPS and proteins implicated in cardiovascular disease and inflammation in patients with heart failure.

EXPERIMENTAL DESIGN: Plasma samples from 300 individuals in HARVEST-Malmö trial hospitalized for the diagnosis of heart failure (mean age 74.9±11.5 years; 30.0% female), were analyzed with a proximity extension assay consisting of 92 proteins. A Bonferroni-corrected p-value of 0.05/92 = 5.4 × 10-4 was considered significant in the initial age and sex-adjusted analyses. Presence of SPS was defined as eGFRcystatinC ≤60% of eGFRcreatinine .

RESULTS: SPS presented with significant associations (p < 5.4 × 10-4 ) in age and sex-adjusted logistic regressions with elevated levels of six proteins; scavenger receptor cysteine rich type 1 protein M130, tumor necrosis factor receptor 1, tumor necrosis factor receptor 2, osteoprotegerin, interleukin-2 receptor subunit alpha, and tyrosine-protein kinase receptor UFO. All proteins remained associated (p < 0.05) with SPS after multivariate adjustments.

CONCLUSIONS AND CLINICAL RELEVANCE: In heart failure patients, SPS was associated with proteins linked to atherosclerosis and cell proliferation. This article is protected by copyright. All rights reserved.

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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Proteomics Clinical Applications
volume
15
issue
4
article number
2000089
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:33682349
  • scopus:85102736029
ISSN
1862-8354
DOI
10.1002/prca.202000089
language
English
LU publication?
yes
id
b63b5e2c-b831-4ad4-a994-269e62de0275
date added to LUP
2021-03-11 14:32:51
date last changed
2024-06-13 08:40:04
@article{b63b5e2c-b831-4ad4-a994-269e62de0275,
  abstract     = {{<p>PURPOSE: The "Shrunken pore syndrome" (SPS) is characterized by a difference in renal filtration between cystatin C and creatinine, resulting in a low eGFRcystatinC /eGFRcreatinine -ratio. Studies have demonstrated a high risk for cardiovascular morbidity and mortality for patients with SPS. In this discovery study, we explored associations between SPS and proteins implicated in cardiovascular disease and inflammation in patients with heart failure.</p><p>EXPERIMENTAL DESIGN: Plasma samples from 300 individuals in HARVEST-Malmö trial hospitalized for the diagnosis of heart failure (mean age 74.9±11.5 years; 30.0% female), were analyzed with a proximity extension assay consisting of 92 proteins. A Bonferroni-corrected p-value of 0.05/92 = 5.4 × 10-4 was considered significant in the initial age and sex-adjusted analyses. Presence of SPS was defined as eGFRcystatinC ≤60% of eGFRcreatinine .</p><p>RESULTS: SPS presented with significant associations (p &lt; 5.4 × 10-4 ) in age and sex-adjusted logistic regressions with elevated levels of six proteins; scavenger receptor cysteine rich type 1 protein M130, tumor necrosis factor receptor 1, tumor necrosis factor receptor 2, osteoprotegerin, interleukin-2 receptor subunit alpha, and tyrosine-protein kinase receptor UFO. All proteins remained associated (p &lt; 0.05) with SPS after multivariate adjustments.</p><p>CONCLUSIONS AND CLINICAL RELEVANCE: In heart failure patients, SPS was associated with proteins linked to atherosclerosis and cell proliferation. This article is protected by copyright. All rights reserved.</p>}},
  author       = {{Xhakollari, Liana and Jujic, Amra and Molvin, John and Nilsson, Peter and Holm, Hannes and Bachus, Erasmus and Leosdottir, Margret and Grubb, Anders and Christensson, Anders and Magnusson, Martin}},
  issn         = {{1862-8354}},
  language     = {{eng}},
  month        = {{03}},
  number       = {{4}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Proteomics Clinical Applications}},
  title        = {{Proteins linked to atherosclerosis and cell proliferation are associated with the shrunken pore syndrome in heart failure patients}},
  url          = {{http://dx.doi.org/10.1002/prca.202000089}},
  doi          = {{10.1002/prca.202000089}},
  volume       = {{15}},
  year         = {{2021}},
}