Stimulation-induced damage in rabbit fast-twitch skeletal muscles: a quantitative morphological study of the influence of pattern and frequency
(1993) In Cell and Tissue Research 273(2). p.357-362- Abstract
- The aim of this study was to determine whether muscle fibre degeneration brought about by chronic low-frequency electrical stimulation was related to the pattern and frequency of stimulation. Rabbit fast-twitch muscles, tibialis anterior and extensor digitorum longus, were stimulated for 9 days with pulse trains ranging in frequency from 1.25 Hz to 10 Hz. Histological data from these muscles were analysed with multivariate statistical techniques. At the lower stimulation frequencies there was a significantly lower incidence of degenerating muscle fibres. Fibres that reacted positively with an antineonatal antibody were most numerous in the sections that revealed the most degeneration. The dependence on frequency was generally similar for... (More)
- The aim of this study was to determine whether muscle fibre degeneration brought about by chronic low-frequency electrical stimulation was related to the pattern and frequency of stimulation. Rabbit fast-twitch muscles, tibialis anterior and extensor digitorum longus, were stimulated for 9 days with pulse trains ranging in frequency from 1.25 Hz to 10 Hz. Histological data from these muscles were analysed with multivariate statistical techniques. At the lower stimulation frequencies there was a significantly lower incidence of degenerating muscle fibres. Fibres that reacted positively with an antineonatal antibody were most numerous in the sections that revealed the most degeneration. The dependence on frequency was generally similar for the two muscles, but the extensor digitorum longus muscles showed more degeneration than the tibialis anterior at every frequency. Muscles subjected to 10 Hz intermittent stimulation showed significantly less degeneration than muscles stimulated with 5 Hz continuously, although the aggregate number of impulses delivered was the same. The incidence of degeneration in the extensor digitorum longus muscles stimulated at 1.25 Hz was indistinguishable from that in control, unstimulated muscles; for the tibialis anterior muscles, this was also true for stimulation at 2.5 Hz. We conclude that damage is not an inevitable consequence of electrical stimulation. The influence of pattern and frequency on damage should be taken into account when devising neuromuscular stimulation regimes for clinical use. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1107492
- author
- Lexell, Jan LU ; Jarvis, Jonathan ; Downham, David and Salmons, Stanley
- publishing date
- 1993
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Muscle, Histochemistry, Degeneration, Morphometry, Immuno-histochemistry, Stimulation, chronic, Rabbit
- in
- Cell and Tissue Research
- volume
- 273
- issue
- 2
- pages
- 357 - 362
- publisher
- Springer
- external identifiers
-
- pmid:8364972
- scopus:0027323704
- ISSN
- 1432-0878
- DOI
- 10.1007/BF00312838
- language
- English
- LU publication?
- no
- id
- b65dbc4b-66ef-41a6-808c-6bde8dce4b02 (old id 1107492)
- date added to LUP
- 2016-04-01 12:13:28
- date last changed
- 2021-01-03 06:10:59
@article{b65dbc4b-66ef-41a6-808c-6bde8dce4b02,
abstract = {{The aim of this study was to determine whether muscle fibre degeneration brought about by chronic low-frequency electrical stimulation was related to the pattern and frequency of stimulation. Rabbit fast-twitch muscles, tibialis anterior and extensor digitorum longus, were stimulated for 9 days with pulse trains ranging in frequency from 1.25 Hz to 10 Hz. Histological data from these muscles were analysed with multivariate statistical techniques. At the lower stimulation frequencies there was a significantly lower incidence of degenerating muscle fibres. Fibres that reacted positively with an antineonatal antibody were most numerous in the sections that revealed the most degeneration. The dependence on frequency was generally similar for the two muscles, but the extensor digitorum longus muscles showed more degeneration than the tibialis anterior at every frequency. Muscles subjected to 10 Hz intermittent stimulation showed significantly less degeneration than muscles stimulated with 5 Hz continuously, although the aggregate number of impulses delivered was the same. The incidence of degeneration in the extensor digitorum longus muscles stimulated at 1.25 Hz was indistinguishable from that in control, unstimulated muscles; for the tibialis anterior muscles, this was also true for stimulation at 2.5 Hz. We conclude that damage is not an inevitable consequence of electrical stimulation. The influence of pattern and frequency on damage should be taken into account when devising neuromuscular stimulation regimes for clinical use.}},
author = {{Lexell, Jan and Jarvis, Jonathan and Downham, David and Salmons, Stanley}},
issn = {{1432-0878}},
keywords = {{Muscle; Histochemistry; Degeneration; Morphometry; Immuno-histochemistry; Stimulation; chronic; Rabbit}},
language = {{eng}},
number = {{2}},
pages = {{357--362}},
publisher = {{Springer}},
series = {{Cell and Tissue Research}},
title = {{Stimulation-induced damage in rabbit fast-twitch skeletal muscles: a quantitative morphological study of the influence of pattern and frequency}},
url = {{http://dx.doi.org/10.1007/BF00312838}},
doi = {{10.1007/BF00312838}},
volume = {{273}},
year = {{1993}},
}