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Effects of intravenous nutrition on lipoprotein metabolism, body composition, weight gain, and uremic state in experimental uremia in rats

Wennberg, Annika ; Norbeck, HE ; Sterner, Gunnar LU and Lundholm, K (1991) In Journal of Nutrition 121(9). p.1439-1446
Abstract
The effect on serum lipids, lipoprotein fractions, body composition, weight gain and uremic state of including fat in intravenous nutrition was evaluated in rats with chronic uremia. Uremic rats were given high energy (1385 kJ.kg body weight-1.day-1), low nitrogen (0.6 g N.kg body weight-1.day-1) total parenteral nutrition (TPN) for 12 d with either glucose or glucose plus 30% lipids (Intralipid) as the energy source. Additional uremic and nonuremic groups were fed a standard diet orally. During TPN, serum triglyceride and cholesterol levels were slightly higher in rats fed lipid-based TPN compared to those administered glucose-based TPN or fed the oral diet; but there were no differences 8 h after feeding. The serum lipoprotein fractions... (More)
The effect on serum lipids, lipoprotein fractions, body composition, weight gain and uremic state of including fat in intravenous nutrition was evaluated in rats with chronic uremia. Uremic rats were given high energy (1385 kJ.kg body weight-1.day-1), low nitrogen (0.6 g N.kg body weight-1.day-1) total parenteral nutrition (TPN) for 12 d with either glucose or glucose plus 30% lipids (Intralipid) as the energy source. Additional uremic and nonuremic groups were fed a standard diet orally. During TPN, serum triglyceride and cholesterol levels were slightly higher in rats fed lipid-based TPN compared to those administered glucose-based TPN or fed the oral diet; but there were no differences 8 h after feeding. The serum lipoprotein fractions showed accumulation of lipids in LDL resulting from the lipid-based TPN but no differences in VLDL. In orally fed uremic rats, more lipids were found in HDL than in the TPN-treated rats. The fractional clearance of the fat emulsion was normal and independent of the nutrition composition. Uremic rats administered lipid-based TPN for 21 d had the same weight gain as orally fed, nonuremic control rats (23 +/- 3 vs. 22 +/- 2%); glucose-based TPN did not support normal growth (10 +/- 1%). Uremic rats fed orally did not grow and retained significantly more body water than TPN-fed uremic rats. In uremic animals, lipid-based TPN also was associated with normal body composition despite significantly lower levels of carnitine in plasma, skeletal muscle and heart tissue. Complete intravenous nutrition with 30% of the nonprotein energy as fat and slightly reduced amino acids promoted normal weight gain and body composition and improved the uremic state. This did not occur in uremic rats either fed glucose-based TPN or a standard diet given orally. (Less)
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author
; ; and
publishing date
type
Contribution to journal
publication status
published
in
Journal of Nutrition
volume
121
issue
9
pages
1439 - 1446
publisher
Oxford University Press
external identifiers
  • scopus:0026048741
ISSN
1541-6100
DOI
10.1093/jn/121.9.1439
language
English
LU publication?
no
id
b68cad32-473c-4519-94d7-b73805961d67
date added to LUP
2019-10-26 22:24:01
date last changed
2021-10-25 04:00:32
@article{b68cad32-473c-4519-94d7-b73805961d67,
  abstract     = {{The effect on serum lipids, lipoprotein fractions, body composition, weight gain and uremic state of including fat in intravenous nutrition was evaluated in rats with chronic uremia. Uremic rats were given high energy (1385 kJ.kg body weight-1.day-1), low nitrogen (0.6 g N.kg body weight-1.day-1) total parenteral nutrition (TPN) for 12 d with either glucose or glucose plus 30% lipids (Intralipid) as the energy source. Additional uremic and nonuremic groups were fed a standard diet orally. During TPN, serum triglyceride and cholesterol levels were slightly higher in rats fed lipid-based TPN compared to those administered glucose-based TPN or fed the oral diet; but there were no differences 8 h after feeding. The serum lipoprotein fractions showed accumulation of lipids in LDL resulting from the lipid-based TPN but no differences in VLDL. In orally fed uremic rats, more lipids were found in HDL than in the TPN-treated rats. The fractional clearance of the fat emulsion was normal and independent of the nutrition composition. Uremic rats administered lipid-based TPN for 21 d had the same weight gain as orally fed, nonuremic control rats (23 +/- 3 vs. 22 +/- 2%); glucose-based TPN did not support normal growth (10 +/- 1%). Uremic rats fed orally did not grow and retained significantly more body water than TPN-fed uremic rats. In uremic animals, lipid-based TPN also was associated with normal body composition despite significantly lower levels of carnitine in plasma, skeletal muscle and heart tissue. Complete intravenous nutrition with 30% of the nonprotein energy as fat and slightly reduced amino acids promoted normal weight gain and body composition and improved the uremic state. This did not occur in uremic rats either fed glucose-based TPN or a standard diet given orally.}},
  author       = {{Wennberg, Annika and Norbeck, HE and Sterner, Gunnar and Lundholm, K}},
  issn         = {{1541-6100}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{1439--1446}},
  publisher    = {{Oxford University Press}},
  series       = {{Journal of Nutrition}},
  title        = {{Effects of intravenous nutrition on lipoprotein metabolism, body composition, weight gain, and uremic state in experimental uremia in rats}},
  url          = {{http://dx.doi.org/10.1093/jn/121.9.1439}},
  doi          = {{10.1093/jn/121.9.1439}},
  volume       = {{121}},
  year         = {{1991}},
}