Random Boolean network models and the yeast transcriptional network
Kauffman, Stuart ; Peterson, Carsten LU ; Samuelsson, Björn LU and Troein, Carl LU
(2003)
In Proceedings of the National Academy of Sciences
100(25).
p.14796-14799
- Abstract
- The recently measured yeast transcriptional network is analyzed in terms of simplified Boolean network models, with the aim of determining feasible rule structures, given the requirement of stable solutions of the generated Boolean networks. We find that, for ensembles of generated models, those with canalyzing Boolean rules are remarkably stable, whereas those with random Boolean rules are only marginally stable. Furthermore, substantial parts of the generated networks are frozen, in the sense that they reach the same state, regardless of initial state. Thus, our ensemble approach suggests that the yeast network shows highly ordered dynamics.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/292555
- author
- Kauffman, Stuart
; Peterson, Carsten
LU
; Samuelsson, Björn
LU
and Troein, Carl
LU
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- genetic networks, dynamical systems
- in
- Proceedings of the National Academy of Sciences
- volume
- 100
- issue
- 25
- pages
- 14796 - 14799
- publisher
- National Academy of Sciences
- external identifiers
-
- wos:000187227200036
- scopus:0345598902
- pmid:14657375
- ISSN
- 1091-6490
- DOI
- 10.1073/pnas.2036429100
- language
- English
- LU publication?
- yes
- id
- b69667e3-e569-4aed-a73a-b4ba8eb8af2e (old id 292555)
- alternative location
- http://www.pnas.org/cgi/content/abstract/2036429100v1
- date added to LUP
- 2016-04-01 11:59:34
- date last changed
- 2024-04-23 00:52:33
@article{b69667e3-e569-4aed-a73a-b4ba8eb8af2e,
abstract = {{The recently measured yeast transcriptional network is analyzed in terms of simplified Boolean network models, with the aim of determining feasible rule structures, given the requirement of stable solutions of the generated Boolean networks. We find that, for ensembles of generated models, those with canalyzing Boolean rules are remarkably stable, whereas those with random Boolean rules are only marginally stable. Furthermore, substantial parts of the generated networks are frozen, in the sense that they reach the same state, regardless of initial state. Thus, our ensemble approach suggests that the yeast network shows highly ordered dynamics.}},
author = {{Kauffman, Stuart and Peterson, Carsten and Samuelsson, Björn and Troein, Carl}},
issn = {{1091-6490}},
keywords = {{genetic networks; dynamical systems}},
language = {{eng}},
number = {{25}},
pages = {{14796--14799}},
publisher = {{National Academy of Sciences}},
series = {{Proceedings of the National Academy of Sciences}},
title = {{Random Boolean network models and the yeast transcriptional network}},
url = {{http://dx.doi.org/10.1073/pnas.2036429100}},
doi = {{10.1073/pnas.2036429100}},
volume = {{100}},
year = {{2003}},
}