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Functional role of extracellular vesicles and lipoproteins in the tumour microenvironment

Menard, Julien A. LU ; Cerezo-Magaña, Myriam LU and Belting, Mattias LU (2018) In Philosophical Transactions of the Royal Society B: Biological Sciences 373(1737).
Abstract

Cancer can be regarded as an invasive organ that exhibits unique plasticity provided by coordinated, cancer cell-stromal cell communication in the tumour microenvironment. Typical stress factors in the tumour niche, such as hypoxia and acidosis, are major drivers and modulators of these events. Recent findings reveal an important role of extracellular vesicles and lipoproteins in cancer cell adaption to exogenous stress. Adaptive mechanisms include stimulation of angiogenesis and increased metastasis. Here, we will discuss the similarities and distinct features of these endogenous nanoparticles and their roles as signalosomes and nutrient sources in cancer. We will focus on the accumulating evidence for a central role of cell-surface... (More)

Cancer can be regarded as an invasive organ that exhibits unique plasticity provided by coordinated, cancer cell-stromal cell communication in the tumour microenvironment. Typical stress factors in the tumour niche, such as hypoxia and acidosis, are major drivers and modulators of these events. Recent findings reveal an important role of extracellular vesicles and lipoproteins in cancer cell adaption to exogenous stress. Adaptive mechanisms include stimulation of angiogenesis and increased metastasis. Here, we will discuss the similarities and distinct features of these endogenous nanoparticles and their roles as signalosomes and nutrient sources in cancer. We will focus on the accumulating evidence for a central role of cell-surface heparan sulphate proteoglycans in the uptake of extracellular vesicles and lipoproteins. This article is part of the discussion meeting issue ‘Extracellular vesicles and the tumour microenvironment’.

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publication status
published
subject
keywords
Exosomes, Hypoxia, Lipoproteins, Microvesicles, Proteoglycans
in
Philosophical Transactions of the Royal Society B: Biological Sciences
volume
373
issue
1737
article number
20160480
publisher
Royal Society
external identifiers
  • scopus:85036594992
  • pmid:29158310
ISSN
1471-2970
DOI
10.1098/rstb.2016.0480
project
Tumor cell adaptation to microenvironmental stress as new molecular targets of cancer treatment
language
English
LU publication?
yes
id
b6cda2ce-25a5-4cb3-9970-86a08d90c73f
date added to LUP
2017-12-21 08:25:01
date last changed
2021-05-05 04:42:11
@article{b6cda2ce-25a5-4cb3-9970-86a08d90c73f,
  abstract     = {<p>Cancer can be regarded as an invasive organ that exhibits unique plasticity provided by coordinated, cancer cell-stromal cell communication in the tumour microenvironment. Typical stress factors in the tumour niche, such as hypoxia and acidosis, are major drivers and modulators of these events. Recent findings reveal an important role of extracellular vesicles and lipoproteins in cancer cell adaption to exogenous stress. Adaptive mechanisms include stimulation of angiogenesis and increased metastasis. Here, we will discuss the similarities and distinct features of these endogenous nanoparticles and their roles as signalosomes and nutrient sources in cancer. We will focus on the accumulating evidence for a central role of cell-surface heparan sulphate proteoglycans in the uptake of extracellular vesicles and lipoproteins. This article is part of the discussion meeting issue ‘Extracellular vesicles and the tumour microenvironment’.</p>},
  author       = {Menard, Julien A. and Cerezo-Magaña, Myriam and Belting, Mattias},
  issn         = {1471-2970},
  language     = {eng},
  month        = {01},
  number       = {1737},
  publisher    = {Royal Society},
  series       = {Philosophical Transactions of the Royal Society B: Biological Sciences},
  title        = {Functional role of extracellular vesicles and lipoproteins in the tumour microenvironment},
  url          = {http://dx.doi.org/10.1098/rstb.2016.0480},
  doi          = {10.1098/rstb.2016.0480},
  volume       = {373},
  year         = {2018},
}