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Okinawa-Based Nordic Diet Decreases Plasma Levels of IAPP and IgA against IAPP Oligomers in Type 2 Diabetes Patients

Pocevičiūtė, Dovilė LU orcid ; Roth, Bodil LU ; Ohlsson, Bodil LU and Wennström, Malin LU (2024) In International Journal of Molecular Sciences 25(14).
Abstract

Pancreas-derived islet amyloid polypeptide (IAPP) aggregates and deposits in the pancreas and periphery of Type 2 Diabetes (T2D) patients, contributing to diabetic complications. The excess IAPP can be removed by autoantibodies, and increased levels of immunoglobulin (Ig) G against IAPP have been reported in T2D patients. However, whether other Ig classes are also affected and if the levels can be managed is less known. This pre–post study examines IgA levels against IAPP oligomers (IAPPO-IgA) in T2D patients and assesses the impact of the Okinawa-based Nordic (O-BN) diet—a low-carbohydrate, high-fiber diet—on these levels after following the diet for 3 months. IAPP, IAPPO-IgA, and total IgA levels were measured in... (More)

Pancreas-derived islet amyloid polypeptide (IAPP) aggregates and deposits in the pancreas and periphery of Type 2 Diabetes (T2D) patients, contributing to diabetic complications. The excess IAPP can be removed by autoantibodies, and increased levels of immunoglobulin (Ig) G against IAPP have been reported in T2D patients. However, whether other Ig classes are also affected and if the levels can be managed is less known. This pre–post study examines IgA levels against IAPP oligomers (IAPPO-IgA) in T2D patients and assesses the impact of the Okinawa-based Nordic (O-BN) diet—a low-carbohydrate, high-fiber diet—on these levels after following the diet for 3 months. IAPP, IAPPO-IgA, and total IgA levels were measured in plasma and fecal samples from n = 30 T2D patients collected at baseline, after 3 months of diet, and after additional 4 months of unrestricted diets (a clinical follow-up). The IAPP and IAPPO-IgA levels were significantly lower after 3 months, with the latter also being significantly reduced at the clinical follow-up. The reduction in plasma IAPP and IAPPO-IgA levels correlated with reductions in plasma levels of metabolic and inflammatory markers. Hence, following the O-BN diet for at least 3 months is sufficient to reduce circulating IAPP and IAPPO-IgA levels, which may be principal in managing T2D.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
amylin, diet, IgA, prevention, T2D
in
International Journal of Molecular Sciences
volume
25
issue
14
article number
7665
publisher
MDPI AG
external identifiers
  • scopus:85199793547
ISSN
1422-0067
DOI
10.3390/ijms25147665
language
English
LU publication?
yes
id
b6d20648-4ebe-4360-8953-0bc05e5aa0ed
date added to LUP
2024-10-03 15:21:55
date last changed
2024-10-03 15:22:37
@article{b6d20648-4ebe-4360-8953-0bc05e5aa0ed,
  abstract     = {{<p>Pancreas-derived islet amyloid polypeptide (IAPP) aggregates and deposits in the pancreas and periphery of Type 2 Diabetes (T2D) patients, contributing to diabetic complications. The excess IAPP can be removed by autoantibodies, and increased levels of immunoglobulin (Ig) G against IAPP have been reported in T2D patients. However, whether other Ig classes are also affected and if the levels can be managed is less known. This pre–post study examines IgA levels against IAPP oligomers (IAPP<sub>O</sub>-IgA) in T2D patients and assesses the impact of the Okinawa-based Nordic (O-BN) diet—a low-carbohydrate, high-fiber diet—on these levels after following the diet for 3 months. IAPP, IAPP<sub>O</sub>-IgA, and total IgA levels were measured in plasma and fecal samples from n = 30 T2D patients collected at baseline, after 3 months of diet, and after additional 4 months of unrestricted diets (a clinical follow-up). The IAPP and IAPP<sub>O</sub>-IgA levels were significantly lower after 3 months, with the latter also being significantly reduced at the clinical follow-up. The reduction in plasma IAPP and IAPP<sub>O</sub>-IgA levels correlated with reductions in plasma levels of metabolic and inflammatory markers. Hence, following the O-BN diet for at least 3 months is sufficient to reduce circulating IAPP and IAPP<sub>O</sub>-IgA levels, which may be principal in managing T2D.</p>}},
  author       = {{Pocevičiūtė, Dovilė and Roth, Bodil and Ohlsson, Bodil and Wennström, Malin}},
  issn         = {{1422-0067}},
  keywords     = {{amylin; diet; IgA; prevention; T2D}},
  language     = {{eng}},
  number       = {{14}},
  publisher    = {{MDPI AG}},
  series       = {{International Journal of Molecular Sciences}},
  title        = {{Okinawa-Based Nordic Diet Decreases Plasma Levels of IAPP and IgA against IAPP Oligomers in Type 2 Diabetes Patients}},
  url          = {{http://dx.doi.org/10.3390/ijms25147665}},
  doi          = {{10.3390/ijms25147665}},
  volume       = {{25}},
  year         = {{2024}},
}